Polymer Nanocomposites Based on Poly(ε-caprolactone), Hydroxyapatite and Graphene Oxide

Medeiros, Gabriela S.; Muñoz, Pablo; Oliveira, Camila F. P. de; Silva, Laura C. E. da; Malhotra, Rashmi; Gonçalves, Maria do Carmo; Rosa, Vinícius; Fechine, Guilhermino J. M.

doi:10.1007/s10924-019-01613-w

Cited by 30 publications

(20 citation statements)

References 34 publications

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“…Furthermore, as it will be discussed during the thermal characterization, the addition of nHA could promote higher degrees of crystallinity and, hence, higher stiffness. Although similar results have been reported earlier [ 42 , 43 ], the here-prepared parts showed higher ductility due to the use of a more flexible PHA. The decrease observed in stiffness with increasing nHA content can be attributed to insufficient wetting and impregnation of the nanoparticles by the polymer matrix, mainly due to particle agglomeration during manufacture or processing of the materials [ 44 ].…”

Section: Resultssupporting

confidence: 90%

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

et al. 2020

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In the present study, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] was reinforced with hydroxyapatite nanoparticles (nHA) to produce novel nanocomposites for potential uses in bone reconstruction. Contents of nHA in the 2.5–20 wt % range were incorporated into P(3HB-co-3HHx) by melt compounding and the resulting pellets were shaped into parts by injection molding. The addition of nHA improved the mechanical strength and the thermomechanical resistance of the microbial copolyester parts. In particular, the addition of 20 wt % of nHA increased the tensile (Et) and flexural (Ef) moduli by approximately 64% and 61%, respectively. At the highest contents, however, the nanoparticles tended to agglomerate, and the ductility, toughness, and thermal stability of the parts also declined. The P(3HB-co-3HHx) parts filled with nHA contents of up to 10 wt % matched more closely the mechanical properties of the native bone in terms of strength and ductility when compared with metal alloys and other biopolymers used in bone tissue engineering. This fact, in combination with their biocompatibility, enables the development of nanocomposite parts to be applied as low-stress implantable devices that can promote bone reconstruction and be reabsorbed into the human body.

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Section: Resultssupporting

confidence: 90%

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

et al. 2020

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“…In all examined samples, the water contact angle on the PCL/HA scaffolds is much smaller than that on the pure PCL. Such result demonstrates that presence of the nano-HA enhances the surface hydrophilicity of the PCL scaffolds [21,22].…”

Section: Characterizationmentioning

confidence: 92%

“…In vivo implanted PCL/HA scaffolds in a thigh-bone defect model of lower limb in rabbits were further loaded of 3D printed PCL/HA scaffolds and multi-functional PCL/HA/DOX scaffolds by collagen I respectively according to the method cited in the literatures. [22][23][24] 2.4. In vitro degradation test PCL and PCL/HA scaffolds (0.1g, diameter: 10 mm and height: 2 mm) were prepared as above and then dried in vacuum for 24 h. The scaffolds were suspended in 10 mL of PBS in a dialysis bag.…”

Section: Preparation Of Poly(ε-caprolactone) and Hydroxyapatite (Pcl/ha) Scaffoldsmentioning

confidence: 99%

3D printed multi-functional scaffolds based on poly(ε-caprolactone) and hydroxyapatite composite

Liu

Kang

Liu

et al. 2021

Preprint

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Background: Biodegradable polymeric scaffolds are critical to repair a large bone defect, which can provide a porous and network microenvironment for cell attachment and bone tissue regeneration. A multifunctional biodegradable PCL/HA composite was prepared with the blending of poly(ε-caprolactone) (PCL) and hydroxyapatite nanoparticles (HA). Subsequently, the PCL/HA scaffolds implants were produced by the screw extrusion/melting deposition forming method using PCL/HA composite as a raw material in this work. Results: Through a serial of in vitro assessments, it is found that the PCL/HA composite possesses good biodegradability, good biocompatibility, and steady drug release performance, which can improve the cell proliferation of osteoblast cells MC3T3-E1. Meanwhile, in vivo experiments were carried out for the rats with skull defect and rabbits with bone defects. It is observed that the PCL/HA scaffolds implants allow the adhesion and penetration of bone cells, which enables the growth of bone cells and bone tissue regeneration. With a composite design to load an anticancer drug and achieve sustained drug release, the scaffolds could enhance bone repair and be expected to inhibit the tumor cells and improve patient outcomes. Conclusions: This work signifies that PCL/HA composite can be used as the potential biodegradable scaffolds for bone repairing after bone malignant tumor resection.

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“…[ 8 ] Graphene oxide (GO) differs from graphene in that it has oxygenated groups on its surface, which results in a material with reduced mechanical strength and electrical and thermal conductivity when compared to graphene. [ 9,10 ] However, the presence of oxygenated groups facilitates dispersion in polar solvents [ 11 ] and can also works as active sites that facilitate chemical functionalization which enables tailoring the materials properties. [ 12–14 ]…”

Section: Introductionmentioning

confidence: 99%

“…For these reasons, graphene and its derivatives have become quite promising, being investigated for the production of sensors, [ 15 ] biosensors, [ 16 ] capacitors, [ 17 ] transistors, [ 18 ] batteries, [ 19 ] photovoltaic cells, [ 20 ] catalysts, [ 21 ] adsorbents for effluent treatment, [ 22 ] and as polymer reinforcement. [ 10,23 ] Among such applications, the use of these nanomaterials as a reinforcement in the production of nanocomposites has been promising as it results in materials with enhanced mechanical, electrical, barrier properties upon introduction of low filler contents allowing a wide variety of applications with a relatively low cost. [ 24 ]…”

Section: Introductionmentioning

confidence: 99%

Interface adjustment between poly(ethylene terephthalate) and graphene oxide in order to enhance mechanical and thermal properties of nanocomposites

Souza

Pinto

Silva

et al. 2021

Polymer Engineering & Sci

Self Cite

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There is great interest in the use of graphene and derivatives in the production of polymer nanocomposites as it provides improvements in the properties of the materials to which they are associated. Such improvements depend heavily on filler dispersion and the interaction between the nanomaterials and the matrix. This work aimed to study the compatibility of graphene oxide (GO) with a poly(ethylene terephthalate) matrix. For this, graphite was modified using Hummers method, using reaction times of 3 and 6 h. The obtained GO was functionalized with amine, amide, and magnetite groups (FGO). The effects of the oxidation degree, functionalization and concentration of the nanofillers on the dispersion and consequently on the properties of the polymer nanocomposites were evaluated. The nanocomposites were synthesized by the solid–solid deposition method followed by the melt mixing technique. It was observed that lower concentrations of nanofiller associated with the lower degree of oxidation and functionalization improved the interaction of the nanofillers with the matrix, which resulted in better mechanical properties under tensile stresses for strain at break, maximum stress, Young's modulus and toughness. It was also observed that the glass transition and crystallization of nanocomposites increased due to a nucleating effect of the nanofillers.

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Polymer Nanocomposites Based on Poly(ε-caprolactone), Hydroxyapatite and Graphene Oxide

Cited by 30 publications

References 34 publications

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

3D printed multi-functional scaffolds based on poly(ε-caprolactone) and hydroxyapatite composite

Interface adjustment between poly(ethylene terephthalate) and graphene oxide in order to enhance mechanical and thermal properties of nanocomposites

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