Polymer modified quartz tuning fork (QTF) sensor array for detection of breath as a biomarker for diabetes

Parmar, Saurabh; Ray, Bishakha; Viswakarma, Satyendra; Rath, Susmita; Datar, Suwarna

doi:10.1016/j.snb.2022.131524

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…The sensor indicated the most increased sensing response for 50 ppm of acetone at 80 • C, and also demonstrated an exceptional linearity between blood glucose levels and the response. Parmar et al (2022) [135], used a polymer-modified sensor array, consisting of three sensors, in order to detect acetone concentrations ranging from 5 to 400 ppm. Moreover, data derived from the acetone sensor combined with individuals' breath samples were exploited in order to distinguish individuals with no diabetes history, diabetic patients, and high metabolic rate individuals (e.g., people with more than average physical activity).…”

Section: Materials Used For the Development Of Wo 3 -Based Sensors Re...mentioning

confidence: 99%

The Role of Nano-Sensors in Breath Analysis for Early and Non-Invasive Disease Diagnosis

Lagopati,

Valamvanos,

Proutsou

et al. 2023

Chemosensors

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Early-stage, precise disease diagnosis and treatment has been a crucial topic of scientific discussion since time immemorial. When these factors are combined with experience and scientific knowledge, they can benefit not only the patient, but also, by extension, the entire health system. The development of rapidly growing novel technologies allows for accurate diagnosis and treatment of disease. Nanomedicine can contribute to exhaled breath analysis (EBA) for disease diagnosis, providing nanomaterials and improving sensing performance and detection sensitivity. Through EBA, gas-based nano-sensors might be applied for the detection of various essential diseases, since some of their metabolic products are detectable and measurable in the exhaled breath. The design and development of innovative nanomaterial-based sensor devices for the detection of specific biomarkers in breath samples has emerged as a promising research field for the non-invasive accurate diagnosis of several diseases. EBA would be an inexpensive and widely available commercial tool that could also be used as a disease self-test kit. Thus, it could guide patients to the proper specialty, bypassing those expensive tests, resulting, hence, in earlier diagnosis, treatment, and thus a better quality of life. In this review, some of the most prevalent types of sensors used in breath-sample analysis are presented in parallel with the common diseases that might be diagnosed through EBA, highlighting the impact of incorporating new technological achievements in the clinical routine.

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Section: Materials Used For the Development Of Wo 3 -Based Sensors Re...mentioning

confidence: 99%

The Role of Nano-Sensors in Breath Analysis for Early and Non-Invasive Disease Diagnosis

Lagopati,

Valamvanos,

Proutsou

et al. 2023

Chemosensors

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show abstract

“…Furthermore, the effect of the sensing films' thickness was eliminated by Sensors 2023, 23, 9823 6 of 15 constructing all the sensors with thicknesses close to 200 nm. The characterization process performed in the present work only corresponds to the calibration of the gas sensor array, as is described in other works in the literature [35,42,43].…”

Section: Gas Sensor Response Measurementmentioning

confidence: 99%

Acetone Detection and Classification as Biomarker of Diabetes Mellitus Using a Quartz Crystal Microbalance Gas Sensor Array

Rodríguez-Torres,

Altuzar,

Mendoza-Barrera

et al. 2023

Sensors

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A gas sensor array was developed and evaluated using four high-frequency quartz crystal microbalance devices (with a 30 MHz resonant frequency in fundamental mode). The QCM devices were coated with ethyl cellulose (EC), polymethylmethacrylate (PMMA), Apiezon L (ApL), and Apiezon T (ApT) sensing films, and deposited by the ultrasonic atomization method. The objective of this research was to propose a non-invasive technique for acetone biomarker detection, which is associated with diabetes mellitus disease. The gas sensor array was exposed to methanol, ethanol, isopropanol, and acetone biomarkers in four different concentrations, corresponding to 1, 5, 10, and 15 µL, at temperature of 22 °C and relative humidity of 20%. These samples were used because human breath contains them and they are used for disease detection. Moreover, the gas sensor responses were analyzed using principal component analysis and discriminant analysis, achieving the classification of the acetone biomarker with a 100% membership percentage when its concentration varies from 327 to 4908 ppm, and its identification from methanol, ethanol, and isopropanol.

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“…For example, in the production or synthesis of various chemicals, monitoring the change of their density and viscosity under high temperature and pressure is very important because the changing trend can greatly affect the quality of the chemicals [1]. Moreover, the measurement is also useful in other fields, including transformer oil quality monitoring [2], the start-up vibration characterization of space shuttles [3], wine brewing monitoring, bioconcentration detection in the biomanufacturing business [4], and so on.…”

Section: Introductionmentioning

confidence: 99%

Optimized Design of Lithium Niobate Tuning Forks for the Measurement of Fluid Characteristic Parameters

Tang,

Chen,

Zhang

et al. 2023

Micromachines

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The unique double-cantilever beam structure and vibration mode of the tuning fork enable the measuring of fluid density and viscosity synchronously in a decoupling manner. Therefore, it is widely employed in oil and gas development and in petrochemical, food, textile, and other industries. In this paper, quality factors are used to characterize the energy losses of lithium niobate tuning forks when vibrating in a fluid, and the influence parameters, such as length, width, and thickness of the tuning fork arm, etc., of different quality factors are examined with a focus on the viscous quality factor of the fluid. The optimized design of lithium niobate tuning fork dimensions is carried out on this premise, and the analytical solution of the optimal dimension of the lithium niobate tuning fork in the air is obtained. Secondly, the optimal dimension of the lithium niobate tuning fork in fluids is given out by finite element simulation, and the sensitivity of the optimized fork to the viscosity of fluids is investigated. The results show that the optimized tuning fork has a higher quality factor, and thus has a larger parameter measurement range as well as being more sensitive to the change in the fluid density and viscosity. Therefore, the results are of great significance for guiding the preparation and practical application of lithium niobate tuning forks.

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Polymer modified quartz tuning fork (QTF) sensor array for detection of breath as a biomarker for diabetes

Cited by 7 publications

References 37 publications

The Role of Nano-Sensors in Breath Analysis for Early and Non-Invasive Disease Diagnosis

The Role of Nano-Sensors in Breath Analysis for Early and Non-Invasive Disease Diagnosis

Acetone Detection and Classification as Biomarker of Diabetes Mellitus Using a Quartz Crystal Microbalance Gas Sensor Array

Optimized Design of Lithium Niobate Tuning Forks for the Measurement of Fluid Characteristic Parameters

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