Polymer microsphere for water-soluble drug delivery via carbon dot-stabilizing W/O emulsion

Wang, Luyao; Gao, Jianping; An, Zhaolin; Zhao, Xiaoxiang; Yao, Hongduo; Zhang, Man; Tian, Qiang; Zhai, Xiangang; Liu, Yu

doi:10.1007/s10853-018-03197-7

Cited by 19 publications

(5 citation statements)

References 58 publications

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“…Besides, the absorption peaks at 1660 and 1610 cm −1 are assigned to the stretching vibrations of CO and CC bonds, and the disappearance of the doublet features of these two peaks indicates the successful polymerization of AM monomers. [ 19,20 ] The characteristic peaks mentioned above can all be observed in the LMIO FTIR spectrum, in which the typical peaks belonging to glycerol also exist. Therefore, it can be concluded that PAM chains have been achieved successfully in LMIOs and that the presence of glycerol does not influence the catalytic ability of EGaIn to APS.…”

Section: Resultsmentioning

confidence: 98%

Liquid Metal‐Based Organohydrogels for Wearable Flexible Electronics

Chen

Liu

et al. 2023

Adv Materials Technologies

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Currently, developing organohydrogel‐based wearable flexible electronics (WFEs) has aroused intensive research interest, since they possess superior environmental stabilities than hydrogel‐based WFEs, but the development of organohydrogels is still in the infant stage. Herein, an efficient strategy is developed to achieve the fast preparation of organohydrogels by exploring the high reactivity of eutectic gallium–indium alloy in inducing radical polymerization, and constructing the glycerol/water binary solvent system. The obtained organohydrogels, named liquid metal‐based ion‐conducting organohydrogels (LMIOs), possess excellent environmental adaptability over a wide temperature range (−20 to 100 °C) and high transparency. With outstanding mechanical properties and self‐healing abilities, LMIOs can act as strain sensors, showing high sensing sensitivities in broad strain range (0.1–1000%) and fast response speed (<100 ms). Therefore, LMIOs perform well in sensing strains from human motions. Besides, LMIOs can be constructed on latex gloves and prosthetic fingers, forming an LMIO skin on their surfaces. The latex gloves equipped with the LMIO skin can accurately recognize the gesture changes of users. The LMIO skin on the prosthetic finger behaves like human skin, possessing the capability to detect the finger's movements and self‐healing ability. Hence, LMIOs present great prospects in skin‐attachable devices, robotics, and prosthetics.

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Section: Resultsmentioning

confidence: 98%

Liquid Metal‐Based Organohydrogels for Wearable Flexible Electronics

Chen

Liu

et al. 2023

Adv Materials Technologies

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“…Its high dielectric constant also makes it useful as a solvent in lithium ion batteries [31,37,38]. Diethyl phthalate (DEP) dissolves organics and many polymers and is a binding agent in cosmetics and fragrances [39]. Dioctyl phthalate (DOP) is a high production volume solvent, being made on the scale of three billion kilograms a year around the world at low costs.…”

Section: Resultsmentioning

confidence: 99%

ADMET polymerization in affordable, commercially available, high boiling solvents

et al. 2020

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Acyclic diene metathesis polymerization is a powerful technique for creating polymers with precise placement of functional groups. However, due to the need to use high vacuum or other methods to remove the volatile ethylene byproduct and drive the reaction forward, traditional solvents are not feasible. Here we demonstrate the use of three cheap, commercially available solvents as a medium for ADMET polymerizations: propylene carbonate, diethyl phthalate, and dioctyl phthalate. We have shown that by using these solvents, we can increase the molecular weights of ADMET-synthesized polyethylene by over 450% as compared to the bulk polymerization as well as reduce polymerization times from 72 h down to 24 and polymerize challenging, solid monomers.

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“…The use of nanoparticulated drug delivery systems has gained interest in the last decades due to the possibility of control the rate and period of drug delivery [ 1 , 2 ]. These nanoparticulated materials has as an advantage the increase of bioavailability, solubility, and permeability of different drugs molecules that are otherwise difficult to deliver orally [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

et al. 2021

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This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The optimization of parameters affecting nanoparticles formulation was performed using a central composite rotatable design (CCRD). It was demonstrated that the best formulation was achieved when 10 mg of CGP was mixed with 10 μL of PPG and homogenized at 22,000 rpm for 15 min. The physicochemical characterization evidenced that diclofenac was efficiently entrapped, as increases in the thermal stability of the drug were observed. The CGP-PPG@diclofenac nanoparticles showed a globular shape, with smooth surfaces, a hydrodynamic diameter around 275 nm, a polydispersity index (PDI) of 0.342, and a zeta potential of −5.98 mV. The kinetic studies evidenced that diclofenac release followed an anomalous transport mechanism, with a sustained release up to 68 h. These results indicated that CGP-PPG nanoparticles are an effective material for the loading/release of drugs with similar structures to diclofenac sodium.

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Polymer microsphere for water-soluble drug delivery via carbon dot-stabilizing W/O emulsion

Cited by 19 publications

References 58 publications

Liquid Metal‐Based Organohydrogels for Wearable Flexible Electronics

Liquid Metal‐Based Organohydrogels for Wearable Flexible Electronics

ADMET polymerization in affordable, commercially available, high boiling solvents

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

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