Polymer Micelle with Cross-Linked Ionic Core

Abstract

This work reports the design of polymer micelles with cross-linked ionic cores that display high stability. Block ionomer complexes were utilized as a micellar template for the synthesis of the cross-linked micelles. Such micelles represent hydrophilic nanospheres of core-shell morphology. The core comprises a network of the cross-linked polyanions, which is surrounded by the shell of hydrophilic PEO chains.

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice

“…Their synthesis, characterization, and properties have been described earlier. 9,17 Briefly, their hydrodynamic diameters range from 100 to 200 nm, have Notes: Whole blood from a single healthy female volunteer was collected in tubes containing Li-heparin, centrifuged at 800 g for 10 minutes, rinsed two times with phosphate-buffered saline (PBS), and resuspended in PBS at 37°C. Micelles were then added to the blood cell suspension to obtain designated concentrations and a final erythrocyte concentration of 10 8 cells/mL (PBS, pH 7.4).…”

PEGylated polymers for medicine: from conjugation to self-assembled systems

“…162 Specifically, the core was composed of the polyanion polymethacrylate, with a surrounding shell of PEG chains. Crosslinking in the core was achieved through the use of 1,2-ethylene diamine, and the potential for drug encapsulation and subsequent release from the ionic core of the micelle was demonstrated with the anticancer drug cisplatin.…”

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

“…The promising results of these trials suggest that polymeric micelles are likely to find practical use in medicine. Moreover, further advances in polymer chemistry resulted in the development of novel nanomaterials with unique spatial orientation of molecular groups, including dendrimers [150], star-polymers [151], and cross-linked polymer micelles [152][153][154][155]. In parallel, advances in nanomanufacturing and nanofabrication led to the development of carbon nanotubes [156,157], and polymeric nanofibers [158,159].…”

“…Wooley et al have developed cage-like nanostructures on the base of polymeric micelles with hydrophobic core and cross-linked anionic shell [155,235,236]. In addition micelles with cross-linked ionic cores were prepared by self-assembly of ionic blocks of double hydrophilic block copolymers with a condensing agent, followed by chemical cross-linking of ionic blocks [153]. The resulting micelles contain a hydrophilic PEO shell and a cross-linked hydrophilic ionic core, which is swollen in water and can incorporate hydrophilic drugs and imaging agents [237,238].…”