Polymer-Mediated Pinacol Rearrangements

Abstract

Both poly (3,4-ethylenedioxythiophene) and poly(pyrrole) mediate a pinacol rearrangement of 1,2-diols. The yields of ketone or aldehyde products are comparable to those observed for treatment with mineral acids or Lewis acids. The advantage of this protocol is a two-phase reaction medium in hydrocarbon solvents that allows facile recovery of the products by simple filtration of the polymer and removal of solvents. Both the polymer and the hydrocarbon solvent may be recovered and used in subsequent reactions.

Advances and Perspectives in Pinacol Rearrangement Reactions: A Comprehensive Review

“…Pinacol rearrangement is a valuable organic transformation that involves the conversion of 1,2-diols into carbonyl compounds. This study focuses on the utilization of polymers as catalysts to facilitate and control the pinacol rearrangement process [27]. The authors introduce the significance of pinacol rearrangement as a powerful synthetic tool for the construction of carbonyl compounds.…”