Polymer Matrixes Used in Wound Healing Applications

Islam, Md. Sazedul; Rahman, Md. Ashiqur; Hossain, Shafiul; Haque, Papia; Shahruzzaman, Md.; Rahman, Mohammed Mizanur

doi:10.1007/978-981-16-3667-7_11

Cited by 2 publications

(1 citation statement)

References 164 publications

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“…Furthermore, they suffer from unfavorable mechanical properties. To overcome such drawbacks, synthetic polymers including polyurethane, poly-ɛ-caprolactone, polyvinyl alcohol (PVA), cellulose acetate, polyglycolic acid, polylactic acid, polyacrylic acid, and polyethylene glycol could be utilized along with natural ones for wound dressing 25 , 26 . One of the most commonly used polymers in skin tissue engineering based on the electrospinning method is PVA.…”

Section: Introductionmentioning

confidence: 99%

A hybrid structure based on silk fibroin/PVA nanofibers and alginate/gum tragacanth hydrogel embedded with cardamom extract

Irantash,

Gholipour-Kanani,

Najmoddin

et al. 2024

Sci Rep

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Hybrid structures made of natural-synthetic polymers have been interested due to high biological features combining promising physical–mechanical properties. In this research, a hybrid dressing consisting of a silk fibroin (SF)/polyvinyl alcohol (PVA) nanofibers and sodium alginate (SA)/gum tragacanth (GT) hydrogel incorporating cardamom extract as an antibacterial agent was prepared. Accordingly, SF was extracted from cocoons followed by electrospinning in blend form with PVA (SF/PVA ratio: 1:1) under the voltage of 18 kV and the distances of 15 cm. The SEM images confirmed the formation of uniform, bead free fibers with the average diameter of 199 ± 28 nm. FTIR and XRD results revealed the successful extraction of SF and preparation of mixed fibrous mats. Next, cardamom oil extract-loaded SA/GT hydrogel was prepared and the nanofibrous structure was placed on the surface of hydrogel. SEM analysis depicted the uniform morphology of hybrid structure with desirable matching between two layers. TGA analysis showed desired thermal stability. The swelling ratio was found to be 1251% after 24 h for the hybrid structure and the drug was released without any initial burst. MTT assay and cell attachment results showed favorable biocompatibility and cell proliferation on samples containing extract, and antibacterial activity values of 85.35% against S. aureus and 75% against E. coli were obtained as well. The results showed that the engineered hybrid nanofibrous-hydrogel film structure incorporating cardamom oil extract could be a promising candidate for wound healing applications and skin tissue engineering.

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Section: Introductionmentioning

confidence: 99%