Polymer-lipid hybrid nanoparticles: A novel drug delivery system for enhancing the activity of Psoralen against breast cancer

Du, Manling; Ouyang, Yan; Meng, Fanning; Zhang, Xingwang; Ma, Qianqian; Zhuang, Yong; Liu, Hui; Pang, Mujuan; Cai, Tiange; Cai, Yu

doi:10.1016/j.ijpharm.2019.03.006

Cited by 42 publications

(23 citation statements)

References 28 publications

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“…The results were related well with a previous study that reported that increasing the amount of marine lecithin from 1% to 10% led to smaller size of liposome [31]. Additionally, higher entrapment efficiency increased with higher lecithin content [31,32]. Therefore, 3% w/w of lecithin was selected for further study since it could produce a liposome with small particle size (464.0 ± 50.1 nm), narrowest PDI (0.470 ± 0.013), and most pronounced zeta potential value (−32.6 ± 1.3).…”

Section: Liposome and Niosomesupporting

confidence: 91%

Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers

et al. 2020

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This study aimed to develop nanodelivery systems for enhancing the Ocimum sanctum Linn. extract delivery into the skin. Rosmarinic acid (RA) was used as a marker for the quantitative determination of the extract by high-performance liquid chromatography. Nanostructured lipid carriers (NLC), nanoemulsion, liposome, and niosome, were developed and characterized for internal droplet size, polydispersity index (PDI), and zeta potential using photon correlation spectroscopy. Irritation properties of each formulations were investigated by hen’s egg test on the chorioallantoic membrane. In vitro release, skin permeation, and skin retention are determined. NLC was suggested as the most suitable system since it enhances the dermal delivery of RA with the significant skin retention amount of 27.1 ± 1.8% (p < 0.05). Its internal droplet size, PDI, and zeta potential were 261.0 ± 5.3 nm, 0.216 ± 0.042, and −45.4 ± 2.4 mV, respectively. RA released from NLC with a sustained release pattern with the release amount of 1.29 ± 0.15% after 24 h. NLC induced no irritation and did not permeate through the skin. Therefore, NLC containing O. sanctum extract was an attractive dermal delivery system that was safe and enhanced dermal delivery of RA. It was suggested for further used as topical anti-ageing products.

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Section: Liposome and Niosomesupporting

confidence: 91%

Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers

et al. 2020

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“…Regarding lipid nanoparticles, only systematic studies have been reported to aid in understanding the variables that influence the preparation of the carriers; among them, the contributions of Martínez-Acevedo et al [54] on the influence of the used recipe and Noriega-Pelaez [55] on the study of the particle preparation process are highlighted. Concerning the hybrid particles, research works to date have focused primarily on the impact of the starting materials on the particle characteristics [5,9,12,23,56].…”

Section: Physicochemical Fundamentals Of the Nanoprecipitation Techniquementioning

confidence: 99%

“…Regarding the carriers prepared by nanoprecipitation, among the reported developments of particles that could theoretically allow them a better in vivo performance are: (i) particle sizes lesser than 100 nm for polymeric nanospheres [25,26,34], solid lipid nanoparticles [71], and hybrid nanoparticles [7,34,56], (ii) positively charged polymeric nanospheres by using chitosan [72] and Eudragit ® RL 100 [18] as polymers or positively charged hybrid nanoparticles prepared from lipids as the stearylamine [5], (iii) stealth polymeric nanospheres [17,27] and stealth hybrid particles [4][5][6][7][8], and (iv) targeted cancer hybrid particles [7,59].…”

Section: In Vivo Performance Of Carriers Prepared By Nanoprecipitationmentioning

confidence: 99%

“…For example, up to 2300 ppm of tetrahydrofuran can be detected in lipid nanoparticles, which exceed the limit of 720 ppm established by the ICH [75]. However, as shown in Table 4, the safety tests including hematological studies on mice [27], hemolysis assays on human blood [8] or with erythrocytes [5], MTT assay on alveolar epithelial cells [34] or osteoblasts [23], cell viability on cancer cells [9,11], and histological examination of mice [56], evidence concerns on the safety of that particles, and in general, neither of the particles were prepared via nanoprecipitation. Moreover, nanoparticles reduce the toxicity of the active molecules [8,57].…”

Section: Safety and Efficacy Of Carriers Prepared By Nanoprecipitatiomentioning

confidence: 99%

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Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics

Martínez-Muñoz¹,

Ospina-Giraldo²,

Mora-Huertas³

2021

Nano- And Microencapsulation - Techniques and Applications

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Nanoprecipitation technique, also named solvent injection, spontaneous emulsification, solvent displacement, solvent diffusion, interfacial deposition, mixinginduced nanoprecipitation, or flash nanoprecipitation, is recognized as a useful and versatile strategy for trapping active molecules on the submicron and nanoscale levels. Thus, these particles could be intended among others, for developing innovative pharmaceutical products bearing advantages as controlled drug release, target therapeutic performance, or improved stability and organoleptic properties. On this basis, this chapter offers readers a comprehensive revision of the state of the art in research on carriers to be used for pharmaceutical applications and developed by the nanoprecipitation method. In this sense, the starting materials, the particle characteristics, and the in vitro and in vivo performances of the most representative of these carriers, i.e., polymer, lipid, and hybrid particles have been analyzed in a comparative way searching for a general view of the obtained behaviors.

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“…In a recent study, psoralen that had been encapsulated in polymer -lipid hybrid nanocarrier had not only displayed improved water solubility but also displayed an increased inhibitory effect against MCF-7 tumors in vivo as compared to non-encapsulated psoralen. This is due to the passive accumulation of encapsulated psoralen in the tumor and extended circulation time, which brings about a lengthened exposure of the psoralen toward the tumor (Du et al, 2019). Gut microbes also metabolize the consumed psoralen and angelicin, therefore encapsulation might improve the transfer of angelicin to the targeted site (Liu et al, 2019).…”

Section: Future New Research Horizonsmentioning

confidence: 99%

Angelicin—A Furocoumarin Compound With Vast Biological Potential

et al. 2020

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Angelicin, a member of the furocoumarin group, is related to psoralen which is well known for its effectiveness in phototherapy. The furocoumarins as a group have been studied since the 1950s but only recently has angelicin begun to come into its own as the subject of several biological studies. Angelicin has demonstrated anti-cancer properties against multiple cell lines, exerting effects via both the intrinsic and extrinsic apoptotic pathways, and also demonstrated an ability to inhibit tubulin polymerization to a higher degree than psoralen. Besides that, angelicin too demonstrated anti-inflammatory activity in inflammatory-related respiratory and neurodegenerative ailments via the activation of NF-kB pathway. Angelicin also showed pro-osteogenesis and pro-chondrogenic effects on osteoblasts and pre-chondrocytes respectively. The elevated expression of proosteogenic and chondrogenic markers and activation of TGF-b/BMP, Wnt/b-catenin pathway confirms the positive effect of angelicin bone remodeling. Angelicin also increased the expression of estrogen receptor alpha (ERa) in osteogenesis. Other bioactivities, such as anti-viral and erythroid differentiating properties of angelicin, were also reported by several researchers with the latter even displaying an even greater aptitude as compared to the commonly prescribed drug, hydroxyurea, which is currently on the market. Apart from that, recently, a new application for angelicin against periodontitis had been studied, where reduction of bone loss was indirectly caused by its anti-microbial properties. All in all, angelicin appears to be a promising compound for further studies especially on its mechanism and application in therapies for a multitude of

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Polymer-lipid hybrid nanoparticles: A novel drug delivery system for enhancing the activity of Psoralen against breast cancer

Cited by 42 publications

References 28 publications

Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers

Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers

Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics

Angelicin—A Furocoumarin Compound With Vast Biological Potential

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