Polymer–lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate

Albertini, Beatrice; Passerini, Nadia; Sabatino, Marcello Di; Vitali, Beatrice; Brigidi, Patrizia; Rodriguez, Lorenzo

doi:10.1016/j.ejps.2008.12.009

Cited by 105 publications

(44 citation statements)

References 33 publications

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“…This dosage form was composed of chitosan, which acts as both bioadhesive and permeation enhancer, and gellan gum, an ion-activated polymer that gels when in contact with ions (i.e., vaginal fluid). A similar evaluation was carried out using SVF1 (10 mL/2 g of product) with poloxamer 407-based vaginal in situ gel containing acyclovir (40).…”

Section: Vaginal Routementioning

confidence: 99%

Simulated Biological Fluids with Possible Application in Dissolution Testing

Marques¹,

Löebenberg²,

Almukainzi³

2011

Dissolution Technol.

864

523

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This literature review is a compilation of the composition and, in most cases, the preparation instructions for simulated biological fluids that may be used as dissolution media in the evaluation of dissolution profiles and amount of drug released from pharmaceutical dosage forms. The use of simulated biological fluids can give a better understanding of the release mechanisms and possible in vivo behavior of a product and enhance the predictive capability of the dissolution testing. A summary of the major characteristics of the most used routes of administration that may affect dissolution and absorption of drug substances is presented. The routes and simulated biological fluids covered by this review are:• Parenteral: simulated body fluid and simulated synovial fluid.• Oral: fasted-state simulated gastric fluid, fed-state simulated gastric fluid, fasted-state simulated intestinal fluid, fed-state simulated intestinal fluid, simulated colonic fluid, fasted-state simulated colonic fluid, and fed-state simulated colonic fluid.• Buccal and sublingual: simulated saliva.• Pulmonary: simulated lung fluid.• Vaginal: simulated vaginal fluid and simulated semen.• Ophthalmic: simulated tears.Simulated sweat is also included. Some examples of how these simulated biological fluids are used to evaluate dosage forms are included in each route of administration.

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Section: Vaginal Routementioning

confidence: 99%

Simulated Biological Fluids with Possible Application in Dissolution Testing

Marques¹,

Löebenberg²,

Almukainzi³

2011

Dissolution Technol.

864

523

View full text Add to dashboard Cite

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“…Hence the drug In the case of pure drug and physical mixture shows a sharp peak at 208 °c which was observed due to melting, whereas, in the case of drug-loaded microcapsules, no such characteristic peak was observed at 208 °c, suggesting that drug is molecularly dispersed in the matrix ( fig. 13) [30]. and polymers were compatible with each other [29].…”

Section: -Polymer Interaction Studies (Ft-ir)mentioning

confidence: 99%

“…DSC thermo grams were obtained for the pure drug, a physical mixture of the drug with the selected polymers and optimised microcapsules. During DSC study, samples were heated in a nitrogen atmosphere (flow rate, 20 ml min -1 ) from 30-300 °C at a heating rate of 10 min -1 [30].…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Sustained Release Mucoadhesive Microcapsules of Ramipril by Ionic Gelation Technique: Formulation Design, Optimization and Characterization

Rao

Venkatchalam

2017

Int J Pharm Pharm Sci

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Objective: The major objective of the research work was to design, optimise and characterise sodium alginate based sustained release mucoadhesive microcapsules Methods: An experimental set-up was designed to investigate the optimal combination of mucoadhesive polymers such as carbopol 974P, of ramipril by ionic gelation method.HPMC (K4M and K100M), Na CMC and chitosan and their drug compatibility with respect to reliabilities. Preliminary screening of the formulation variables was accomplished by Taguchi design followed by Box-Behnken design for systematic optimisation. The suitable mathematical model was selected, response surface analysis was performed and optimised formulation was chosen by numerical optimization and desirability function method. Characterization of the prepared microcapsules for several inherent properties like particle size, drug content, sphericity, entrapment efficiency, loose surface crystal study, swelling index, micromeritic properties, moisture content, in vitro drug release, mucoadhesive strength and in vivo antihypertensive activity was performed.Results: Differential Scanning Calorimetry (DSC) thermograms and Fourier Transform Infra-Red (FT-IR) spectral studies revealed no incompatibility between the pure drug and selected polymers. The Conclusion:The resultant sustained release spherical nature of the prepared microcapsules was established by surface morphology studies. mucoadhesive microcapsules of ramipril remained stable when subjected to stress conditions unveiling it as a better alternative delivery system with superior therapeutic efficacy

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“…Elasticity is the rate at which the deformed sample returns to its undeformed condition after the removal of the deforming force. Cohesiveness and elasticity values were calculated according to the following equations: Cohesiveness = AUC 3 /AUC 1 (1)…”

Section: Mechanical Properties Of Formulationsmentioning

confidence: 99%

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

et al. 2014

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Vaginal yeast infections are among the most common reasons for women seeking medical care; it has been estimated that 70-75 % of women have an episode of Candida vaginitis at least once during their lifetime (1). Local administration of antimicrobial agents has been favored in the treatment of vaginitis because of the numerous side effects of systemically applied drugs. Vaginal dosage forms used for this purpose include solutions, gels, creams, ointments, foams, pessaries, tablets and vaginal inserts (1). To achieve a desirable therapeutic effect, vaginal delivery systems need to have the ability to spread onto the vaginal mucosa surface and guarantee an intimate and prolonged contact at the site of application (2). Therefore, localized mucoadhesive dosage forms The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 mPa s)] have been used. First, rheological studies were conducted on chitosan gels. Mechanical, syringeability and mucoadhesive properties of chitosan gels were determined. Release profiles of econazole nitrate and miconazole nitrate from chitosan gels were obtained and evaluated kinetically. In addition, anticandidal activities of formulations were determined. Finally, vaginal retention of chitosan gels in rats was evaluated by in vivo distribution studies. Based on the results, it can be concluded that gels prepared with medium molecular mass chitosan might be effectively used for different antifungal agents in the treatment of vaginal candidiosis, since it has high mucoadhesiveness, suitable mechanical and release properties with good vaginal retention.

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Polymer–lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate

Cited by 105 publications

References 33 publications

Simulated Biological Fluids with Possible Application in Dissolution Testing

Simulated Biological Fluids with Possible Application in Dissolution Testing

Sustained Release Mucoadhesive Microcapsules of Ramipril by Ionic Gelation Technique: Formulation Design, Optimization and Characterization

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

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