Polymer Gels

Osada, Yoshihito; Gong, Jian Ping; Tanaka, Yutaka

doi:10.1081/mc-120027935

Cited by 153 publications

(122 citation statements)

References 73 publications

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“…The samples were then concentrated under vacuum yielding amine end-capped poly(2-isopropyl-2-oxazoline)-co-(2-n-butyl-2-oxazoline) as a powder (PiPr-Bu), 86% yield. 1 …”

Section: Synthesis Of Amine-capped Poly(2-isopropyl-2-oxazoline)-co-(mentioning

confidence: 99%

“…Many natural proteins and polysaccharides form physical gels, typically upon decreasing the temperature, examples of which include gelatin, pectin, agarose, agar and carrageenan 1 . In contrast, synthetic thermo-gelling polymers may undergo a liquid-to-gel transition with increasing temperature and therefore have potential applications ranging, for example, from drug delivery 2 to tissue engineering 3 .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and gelation properties of poly(2-alkyl-2-oxazoline) based thermo-gels

et al. 2016

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A series of new thermo-gelling polymers based on thermo-responsive poly(2-alkyl-2-oxazoline)s has been prepared by grafting different poly(2-alkyl-2-oxazolines) onto a polar carboxymethylcellulose backbone. Thermo-reversible gelation is observed at low concentrations (less than 5% by weight of thermo-gelling polymer). Rheology reveals that these polymers show tuneable gelation temperatures, which vary with concentration and poly(2-oxazoline) composition. This allows the gelation point to be adjusted to biologically relevant temperatures, offering a novel material with potential applications in areas such as drug delivery and tissue engineering.

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“…The samples were then concentrated under vacuum yielding amine end-capped poly(2-isopropyl-2-oxazoline)-co-(2-n-butyl-2-oxazoline) as a powder (PiPr-Bu), 86% yield. 1 …”

Section: Synthesis Of Amine-capped Poly(2-isopropyl-2-oxazoline)-co-(mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and gelation properties of poly(2-alkyl-2-oxazoline) based thermo-gels

et al. 2016

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“…[1][2][3][4][5][6][7][8] Gels can be classified based on their origin, constitution and type of crosslinkage. 9 Depending on the liquid medium in the polymer network, polymer gels can be separated into two classes: hydrophilic gels, otherwise termed hydrogels, and organic gels, also called organogels. A hydrogel is a polymeric material that can swell and absorb a significant amount of water within its structure.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of crosslinked poly(orthosilicate)s based on cyclohexanediol derivatives and their swelling properties

Karadag

Onaran

Sönmez

2010

Polym J

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Condensations of tetraethyl orthosilicate (TEOS) with cyclohexanediol derivative monomers at moderately high temperatures resulted in the creation of crosslinked poly(orthosilicate)s. The structural and thermal properties of the crosslinked poly(orthosilicate)s polymers were determined by Fourier transform infrared spectroscopy, solid-state 13 C and 29 Si crosspolarization magic angle spinning nuclear magnetic resonance, thermogravimetric analysis and differential scanning calorimetry. The synthesized crosslinked polymers were found to be insoluble in common organic solvents, such as tetrahydrofuran, dichloromethane, benzene and acetone, although they displayed swelling abilities in these solvents. The swelling ability of the crosslinked polymers was examined by the swelling test, swelling kinetics and desorption kinetics. The results suggest that crosslinked poly(orthosilicate)s based on cyclohexanediols can find good use as absorbents for organic solvents.

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“…[182][183][184][185] Hydrogels are uniquely useful for a wide range of applications because they can serve as stable niches for the immobilization of proteins and cells. 186 For the former case, protein-bearing hydrogels are often formed to serve as microreactors for use in enzymatic digestion, 165 catalysis, 187 and biosensors.…”

Section: A11 Introductionmentioning

confidence: 99%

A Digital Microfluidic Approach to Proteomic Sample Processing

2009

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Proteome profiling is the identification and quantitation of all proteins in biological samples. An important application of proteome profiling that has received much attention is clinical proteomics, a field that promises the discovery of biomarkers that will be useful for early diagnosis and prognosis of diseases. While clinical proteomic methods vary widely, a common characteristic is the need for (i) extraction of proteins from complex biological fluids and (ii) extensive biochemical processing (reduction, alkylation and enzymatic digestion) prior to analysis. However, the lack of standardized sample handling and processing in proteomics is a major limitation for the field. The conventional macroscale manual sample handling requires multiple containers and transfers, which often leads to sample loss and contamination. For clinical proteomics to be adopted as a gold standard for clinical measures, the issue of irreproducibility needs to be addressed. A potential solution to this problem is to form integrated systems for sample handling and processing, and in this dissertation, I describe my work towards realizing this goal using digital microfluidics (DMF). DMF is a technique characterized by the manipulation of discrete droplets (100 nL -10 L) on an array of electrodes by the application of electrical fields. It is well-suited for carrying out rapid, sequential, miniaturized automated biochemical assays. This thesis demonstrates how DMF can be a powerful tool capable of automating several protein handling and processing steps used in proteomics.iii Methods for implementing proteomic multi-step solution-phase processes (reduction, alkylation, and digestion) on DMF were developed. This was accompanied by the development of heterogenous enzymatic microreactors for efficient protein digestion. Strategies for reducing non-specific adsorption were developed. Finally, in proof-of-concept work, a combination of protein extraction and protein processing was demonstrated on DMF devices.iv ACKNOWLEDGEMENTS

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Polymer Gels

Cited by 153 publications

References 73 publications

Synthesis and gelation properties of poly(2-alkyl-2-oxazoline) based thermo-gels

Synthesis and gelation properties of poly(2-alkyl-2-oxazoline) based thermo-gels

Synthesis of crosslinked poly(orthosilicate)s based on cyclohexanediol derivatives and their swelling properties

A Digital Microfluidic Approach to Proteomic Sample Processing

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