Polymer-Drug Conjugate, a Potential Therapeutic to Combat Breast and Lung Cancer

Alven, Sibusiso; Buyana, Buhle; Aderibigbe, Blessing Atim

doi:10.3390/pharmaceutics12050406

Cited by 69 publications

(25 citation statements)

References 128 publications

(174 reference statements)

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“…This may be provided by entrapping the biomolecules, such as drugs, proteins, DNA, or growth factors, within the polymer matrices. The authors already discussed the carriers of medicaments as particles [ 12 , 13 , 14 ], micelles [ 15 , 16 , 17 ], fibers [ 18 , 19 , 20 ], or polymer-drug conjugates [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

et al. 2021

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Diclofenac sodium salt (DSS)-loaded electrospun nanofiber mats on the base of poly(ε-caprolactone) (PCL) were investigated as biocompatible nanofibrous mats for medical applications with the ability to inhibit bacterial infections. The paper presents the characteristics of fibrous mats made by electrospinning and determines the effect of medicament on the fiber morphology, chemical, mechanical and thermal properties, as well as wettability. PCL and DSS-loaded PCL nanofibrous mats were characterized using scanning electron microscopy, transmission electron microscopy, attenuated total reflectance-Fourier transform infrared spectrometry, dynamic mechanical analysis, and contact angle measurements. Electron paramagnetic resonance measurements confirmed the lifetime of DSS before and after application of high voltage during the electrospinning process. In vitro biocompatibility was studied, and it was proved to be of good viability with ~92% of the diploid human cells culture line composed of lung fibroblast (MRC 5) after 48 h of incubation. Moreover, the significant activity of DSS-loaded nanofibers against cancer cells, Ca Ski and HeLa, was established as well. It was shown that 12.5% (m/V) is the minimal concentration for antibacterial activity when more than 99% of Escherichia coli (Gram-negative) and 99% of Staphylococcus aureus (Gram-positive) have been exterminated.

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Section: Introductionmentioning

confidence: 99%

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

et al. 2021

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“…Polymeric conjugates are another potential delivery vehicle candidate for the treatment of COVID-19 because of several advantages like lower dosages of the required drugs that cause fewer side effects, decreasing the likelihood of drug resistance, and useful for the delivery of multiple drugs with different physicochemical properties. [ 82 ] A wide variety of negatively charged polymers and glycosaminoglycans like heparin, chondroitin sulphate, keratan sulphate, dermatan sulphate, and heparan sulphate have the potentiality to bind to the HIV envelope and resist the entry of viral particles inside the host cells. [ 83 ] Conjugation of azidothymidine (AZT) and ribavirin with synthetic polymers like methacrylates have been investigated broadly.…”

Section: Polymer-based Nano-therapies For Respiratory Injury Treatmentmentioning

confidence: 99%

Polymer-based nano-therapies to combat COVID-19 related respiratory injury: progress, prospects, and challenges

Rana

2021

Journal of Biomaterials Science, Polymer Edition

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The recent coronavirus disease-2019 (COVID-19) outbreak has increased at an alarming rate, representing a substantial cause of mortality worldwide. Respiratory injuries are major COVID-19 related complications, leading to poor lung circulation, tissue scarring, and airway obstruction. Despite an in-depth investigation of respiratory injury’s molecular pathogenesis, effective treatments have yet to be developed. Moreover, early detection of viral infection is required to halt the disease-related long-term complications, including respiratory injuries. The currently employed detection technique (quantitative real-time polymerase chain reaction or qRT-PCR) failed to meet this need at some point because it is costly, time-consuming, and requires higher expertise and technical skills. Polymer-based nanobiosensing techniques can be employed to overcome these limitations. Polymeric nanomaterials have the potential for clinical applications due to their versatile features like low cytotoxicity, biodegradability, bioavailability, biocompatibility, and specific delivery at the targeted site of action. In recent years, innovative polymeric nanomedicine approaches have been developed to deliver therapeutic agents and support tissue growth for the inflamed organs, including the lung. This review highlights the most recent advances of polymer-based nanomedicine approaches in infectious disease diagnosis and treatments. This paper also focuses on the potential of novel nanomedicine techniques that may prove to be therapeutically efficient in fighting against COVID-19 related respiratory injuries.

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“…Polymer-Drug conjugate in which the active drug is incorporated into the polymeric material. Polymer-Drug conjugate is also regarded as polymeric prodrug [112][113][114].…”

Section: Other Approaches For the Treatment Of Cancer And Other Diseases 7 Polymer Drug Conjugatementioning

confidence: 99%

Vitamin Drug conjugate: a systematic review of pharmacological potential

Bhole¹,

Shinde²,

Bonde³

et al. 2021

Bull. of the Kar. Univ. "Chem". Ser.

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Cancer is a chronic disease which can cause death. In traditional chemotherapycytotoxic drugs are used to kill proliferating cancer cells. The cytotoxic agent exhibits less specificity, less biological activity, causes sys-temic toxicity and undesirable side effects. Each year, about 1.8 million of the population are infected and die due to tuberculosis infection. An increase of drug resistance during the tuberculosis treatment is a significant concern. So, it is necessary to develop a new approach or therapies to resolve drug resistance, drug selectivity in tuberculosis infection and the reduction of the side effects of cytotoxic agents and anti-tubercular drugs. This review describes the newly emerging concept of «vitamin drug conjugate». Vitamin-drug conjugate is a specifically carried drug toward the target site, is one of the promising ways to treat chronic diseases like can-cer and tuberculosis and enhance the therapeutic outcome. The purpose of this review is to explore vitamin as a targeting moiety for new anticancer and anti-tubercular drug to overcome challenges, such as non-selectivity, systemic toxicity and multidrug resistance. This approach is beneficial in the treatment of life-threatening disease like cancer, tuberculosis and also in many viral infections.

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Polymer-Drug Conjugate, a Potential Therapeutic to Combat Breast and Lung Cancer

Cited by 69 publications

References 128 publications

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

Polymer-based nano-therapies to combat COVID-19 related respiratory injury: progress, prospects, and challenges

Vitamin Drug conjugate: a systematic review of pharmacological potential

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