Polymer-Derived Janus Particles at Multiple Length Scales

Shao, Yue; Ye, Yilan; Sun, Dayin; Yang, Zhenzhong

doi:10.1021/acs.macromol.2c00512

Cited by 12 publications

(9 citation statements)

References 110 publications

(197 reference statements)

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“…Intramolecular cross-linking of single polymer chains produces molecular-scale Janus particles known as single-chain nanoparticles and dendrimers with a size of ≈ 1-10 nm, depending on molecular weight and cross-linking degree (Figure 8a). [113,114] The rational design of such particles and the development of precise methods for multifunctional integration involve significant challenges due to the complexity of their final structure and the integration of variable payloads. These sophisticated strategies tend to be expensive and time-consuming, making them, in some cases, even impractical for large-scale production.…”

Section: Fabrication Methods Of Chemical and Compositional Anisotropi...mentioning

confidence: 99%

Features of Anisotropic Drug Delivery Systems

Kudryavtseva,

Sukhorukov

2024

Advanced Materials

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Natural materials are anisotropic. Delivery systems occurring in nature, such as viruses, blood cells, pollen, and many others, do have anisotropy, while delivery systems made artificially are mostly isotropic. There is apparent complexity in engineering anisotropic particles or capsules with micron and submicron sizes. Nevertheless, some promising examples of how to fabricate particles with anisotropic shapes or having anisotropic chemical and/or physical properties have been developed. Anisotropy of particles, once they face biological systems, influences their behaviour. Internalisation by the cells, flow in the bloodstream, biodistribution over organs and tissues, directed release, and toxicity of particles regardless of the same chemistry are all reported to be factors of anisotropy of delivery systems. Here, we review the current methods to introduce anisotropy to particles or capsules, including loading with various therapeutic cargo, variable physical properties primarily by anisotropic magnetic properties, controlling directional motion, and making Janus particles. The advantages of combining different anisotropy in one entity for delivery and common problems and limitations for fabrication are under discussion.This article is protected by copyright. All rights reserved

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Section: Fabrication Methods Of Chemical and Compositional Anisotropi...mentioning

confidence: 99%

Features of Anisotropic Drug Delivery Systems

Kudryavtseva,

Sukhorukov

2024

Advanced Materials

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“…In addition, novel popcorn-like all-polymeric nanoparticles can also be observed during the particle morphology evolution. In the existing reports, most of the nonspherical particles obtained based on surface nucleation mechanisms are inorganic and organic hybrids − rather than all-polymer pairs, and most of the preparation of all-polymer nonspherical particles is not based on surface nucleation mechanisms. − Until now, the popcorn-like all-polymeric nanoparticles obtained by morphology regulation based on the surface nucleation mechanism have been rarely reported. Our research is primarily concerned with the encapsulation integrity of PVDF core by the shell layer in composite particles exhibiting intriguing morphologies, which determines whether PVDF within the nanospace is unconfined (α phase), partially confined (α phase and ferroelectric phases), or well-confined (ferroelectric phases).…”

Section: Introductionmentioning

confidence: 99%

Surface Nucleation-Induced Raspberry-like PVDF@P(St-co-MPS-co-AA) Core–Shell Latex Particles via Seeded Emulsion Polymerization and Their High Efficiency for Confined Crystallization of PVDF in Nanospheres

Pan,

Song,

Guo

et al. 2023

Ind. Eng. Chem. Res.

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A novel complex structure of raspberry-like PVDF@P(St-co-MPS-co-AA) (poly(vinylidene fluoride)@poly(styrene-co-trimethoxysilyl propyl methacrylate-co-acrylic acid)) core–shell particles combined with a popcorn-like shape has been successfully fabricated in substantial quantities via emulsifier-free seeded emulsion polymerization based on commercially available PVDF nanospheres. Scanning electron microscopy and transmission electron microscopy investigations suggest that polymerization temperature and addition of AA-catalyzed MPS hydrolysate dominate the formation of popcorn- or raspberry-like core–shell morphology. By tuning the polymerization temperature, it is possible to precisely control the hierarchical surface morphology of the composite particles, including the size and number of P(St-co-MPS-co-AA) protrusions nucleated onto the PVDF seed surface. Furthermore, the cross-linking reaction induced by the MPS hydrolysate constrains the merging of P(St-co-MPS-co-AA) bulges, effectively preventing the formation of exclusively eccentric core–shell particles. The complete wrapping of the PVDF seeds by the P(St-co-MPS-co-AA) copolymer ensures three-dimensionally confined crystallization of PVDF in 180 nm nanospheres, exhibiting a higher encapsulation efficiency in comparison to the PVDF/PS system in the absence of the MPS hydrolysate. The confined crystallization in the complex latex nanospheres has significant implications for the production of polar crystalline phases in PVDF, leading to the coexistence of polar β/γ phases, with the β phase being predominantly dominant, instead of the typical α phase. The enhanced polar phases exhibited by the PVDF@P(St-co-MPS-co-AA) core–shell particles imbue them with considerable potential for application as piezoelectric and ferroelectric materials, making them promising candidates for advanced technological utilization in various fields.

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“…Janus particles, containing distinct multifunctional partitions, have attracted increasing academic and industrial interests due to their ingenious microstructures, controllable preparation, and customizable functionalization. − Most Janus particles are amphiphilic, showing unique behaviors at a biphasic interface . Janus particles have been employed as emulsifiers at the liquid–liquid interface, − stabilizers at the air–liquid interface, − compatibilizers at the solid–solid interface, − and functional layers on the air–solid surface. − Janus particles, meanwhile, can spontaneously assemble as an oriented monolayer at the interface, forming a functional interface in the high-performance composite. ,− Hence, a feasible synthetic strategy is required to control the microstructures of Janus particles and endow them with multifunctionalities.…”

Section: Introductionmentioning

confidence: 99%

Janus Hemispheres through Controlled Polymerization-Induced Phase Separations within Wax Droplets

et al. 2023

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A series of Janus hemispheres with a patchy hemispherical surface and a flat undersurface were synthesized through controlled polymerization-induced phase separation within emulsified wax droplets. The hemispherical shape was generated through the polymerization of styrene within wax droplets, followed by the grafting of hydrophilic polymers on the exposed surface. Then, the patchy hemispherical surface was achieved after introducing the hydrophobic acrylate monomers within wax droplets and controlling the polymerization-induced phase separation. The morphological evolution of patches was recorded via the reaction time, followed by their morphological regulation through the type, feeding amount, and cross-linking degree of acrylate monomers. A functional monomer, vinyl benzyl chloride (VBC), was also used to copolymerize the patches for grafting a zwitterionic polymer via surface-initiated atom transfer radical polymerization (SI-ATRP). The as-obtained Janus hemispheres were employed to fabricate robust coatings with wettability tuned from superhydrophobicity to underwater superoleophobicity by the grafted zwitterionic polymers.

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Polymer-Derived Janus Particles at Multiple Length Scales

Cited by 12 publications

References 110 publications

Features of Anisotropic Drug Delivery Systems

Features of Anisotropic Drug Delivery Systems

Surface Nucleation-Induced Raspberry-like PVDF@P(St-co-MPS-co-AA) Core–Shell Latex Particles via Seeded Emulsion Polymerization and Their High Efficiency for Confined Crystallization of PVDF in Nanospheres

Janus Hemispheres through Controlled Polymerization-Induced Phase Separations within Wax Droplets

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