Polymer cross-linking: a nanogel approach to enhancing the relaxivity of MRI contrast agents

Soleimani, Abdolrasoul; Martínez, Francisco Martínez; Economopoulos, Vasiliki; Foster, Paula J.; Scholl, Timothy J.; Gillies, Elizabeth R.

doi:10.1039/c2tb00352j

Cited by 47 publications

(45 citation statements)

References 47 publications

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“…Soleimani et al 47 also increased the relaxivity of macromolecular Gd 3+ CAs by polymer crosslinking. On the other hand, star nanogels exhibited a slightly lower relaxivity per Gd 3+ ion, but still higher than existing for low molecular weight contrast agents.…”

Section: View Article Onlinementioning

confidence: 99%

Multifunctional hybrid nanogels for theranostic applications

Sierra‐Martin

Fernández-Barbero

2015

Soft Matter

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This paper reviews a wide set of theranostic applications based on the special properties associated with composite nanogels. The nanogels presented here are mostly hybridized with quantum dots, magnetic nanoparticles, and plasmonic metal noble nanoparticles. These inorganic components confer nanogels multifunctional properties that extend their applications from drug delivery systems to diagnosis and therapy. Nanogels can also be surface functionalized with specific ligands to achieve targeted therapy and reduce toxicity. This versatility makes hybrid nanogels very promising agents for imaging, diagnosis and treatment of cancer and other diseases.

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Section: View Article Onlinementioning

confidence: 99%

Multifunctional hybrid nanogels for theranostic applications

Sierra‐Martin

Fernández-Barbero

2015

Soft Matter

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“…Moreover, the hydrogel coating further increases the relaxivities by lowering the diffusion coefficient of water near the particles and prolonging the interaction between the water protons and the high magnetic fields at the surface of the particle. The extent of reduction in the diffusivity of the water molecules depends on the thickness of the gel coating around the magnetic particle [156-159]. This could allow for partial control over the relaxation times by manipulating the swelling/deswelling transition of the nanogel matrix [157].…”

Section: Nanogels In Diagnostics and Imagingmentioning

confidence: 99%

“…One of the best methods to restrict tumbling is by conjugation of the contrast agent to a macromolecular system, and nanogels serve as the perfect hydrophilic platform with flexible loading capacity for entrapment for such agents, which was shown to result in a further relaxivity enhancement. [156,161,162]. Gd 3+ ion is toxic and it is clinically administered in the form of chelates.…”

Section: Nanogels In Diagnostics and Imagingmentioning

confidence: 99%

“…[173,174]. To overcome these challenges, Soleimani et al prepared a nanogel by copolymerization of PEGMA, N-(2-aminoethyl)methacrylamide hydrochloride, and the crosslinker ethylene glycol dimethacrylate under free radical conditions [156]. The reaction conditions were optimized to obtain nanogels with a size on the order of 10 nm.…”

Section: Nanogels In Diagnostics and Imagingmentioning

confidence: 99%

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Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

Soni

Desale

Bronich³

2016

Journal of Controlled Release

494

348

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“…25−28 Despite the advantages of nanogels, only a few nanogel MRI contrast agents have been developed recently 29,30 including one developed previously by the Almutairi group. 23 Our system was composed of polyacrylamide nanogels with metal chelating cross-linkers making it a versatile system for both positron emission tomography (PET) and MRI.…”

Section: ■ Introductionmentioning

confidence: 99%

Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent

Chan¹,

Lux²,

Nishimura

et al. 2015

Biomacromolecules

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Clinically approved small-molecule magnetic resonance imaging (MRI) contrast agents are all rapidly cleared from the body and offer weak signal enhancement. To avoid repeated administration of contrast agent and improve signal-to-noise ratios, agents with stronger signal enhancement and better retention in tumors are needed. Therefore, we focused on hydrogels because of their excellent water accessibility and biodegradability. Gadolinium (Gd)-chelating cross-linkers were incorporated into self-assembled pullulan nanogels to both impart magnetic properties and to stabilize this material that has been extensively studied for medical applications. We show that these Gd-chelating pullulan nanogels (Gd-CHPOA) have the highest reported relaxivity for any hydrogel-based particles and accumulate in the 4T1 tumors in mice at high levels 4 h after injection. This combination offers high signal enhancement and lasts up to 7 days to delineate the tumor clearly for longer imaging time scales. Importantly, this long-term accumulation does not cause any damage or toxicity in major organs up to three months after injection. Our work highlights the clinical potential of Gd-CHPOA as a tumor-imaging MRI contrast agent, permitting tumor identification and assessment with a high signal-to-background ratio.

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Polymer cross-linking: a nanogel approach to enhancing the relaxivity of MRI contrast agents

Cited by 47 publications

References 47 publications

Multifunctional hybrid nanogels for theranostic applications

Multifunctional hybrid nanogels for theranostic applications

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent

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