Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting

Mastrotto, Francesca; Caliceti, Paolo; Amendola, Vincenzo; Bersani, Sara; Magnusson, Johannes P.; Meneghetti, Moreno; Mantovani, Giuseppe; Alexander, Cameron; Salmaso, Stefano

doi:10.1039/c1cc12654g

Cited by 54 publications

(63 citation statements)

References 28 publications

(9 reference statements)

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“…9 Alternatively, thermoresponsive polymers have been used to reversibly mask tumour-targeting ligands, so that upon applying a local temperature gradient, the ligands are exposed, promoting receptor-mediated endocytosis. 10 A further example of this uses gold nano-rods which undergo a localised heating effect when exposed to near-infrared (NIR) light (650-900 nm). This was exploited to trigger a phase transition in surface-grafted PNIPAM.…”

Section: Applications Of Corona-responsive Particlesmentioning

confidence: 99%

“…65 Experimental evidence for the surface exposure was obtained by Mastratto et al PNIPAM-coated AuNPs were synthesised by the grafting to approach (to give polymer chains in the mushroom regime) with hydrophilic cell targeting ligands also included at the surface. 10 Below the LCST of the PNIPAM the polymer effectively shielded the underlying surface by steric effects, but above the LCST the polymers collapsed, exposing the ligands which triggered cellular recognition/internalisation, Fig. 10.…”

Section: Transitions and Macroscopic Outcomesmentioning

confidence: 99%

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To aggregate, or not to aggregate? considerations in the design and application of polymeric thermally-responsive nanoparticles

2013

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The aim of this review is to highlight some of the challenges in designing thermally responsive nanoparticles, where the responsivity is endowed by a responsive polymeric corona. A review of the literature reveals many contradictory observations upon heating these particles through their transition temperature. Indeed, both an increase in size due to aggregation and particle shrinkage have been reported for apparently similar materials. Furthermore, careful review of the literature shows that responsive nanoparticles do not have the same transition temperature or properties as their constituent polymers. These observations raise serious questions as to how to achieve the rational design of a responsive particle with a predictable and reproducible response. Here we highlight specific cases where conflicting results have been observed for spherical particles and put these results into the context of flat-surface grafted polymer brushes to explain the behaviour in terms of grafting density, curvature, chain end effects and the role of the underlying substrate. A better understanding of these observations should lead to the improved design of nanoparticles with real function and applications.

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Section: Applications Of Corona-responsive Particlesmentioning

confidence: 99%

Section: Transitions and Macroscopic Outcomesmentioning

confidence: 99%

To aggregate, or not to aggregate? considerations in the design and application of polymeric thermally-responsive nanoparticles

2013

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“…[65][66][67] The heat generated by light irradiation can accelerate drug release by enhancing polymer degradation or drug diffusion. AuNPs coated with poly(NIPAM-co-acrylamide) (pNIPAM-co-Am) polymers bearing cell-specific ligands have been used to enhance the internalization into cells, 69 and to activate the release of DOX. AuNPs coated with poly(NIPAM-co-acrylamide) (pNIPAM-co-Am) polymers bearing cell-specific ligands have been used to enhance the internalization into cells, 69 and to activate the release of DOX.…”

Section: Plasmonic Nanogelsmentioning

confidence: 99%

Multifunctional hybrid nanogels for theranostic applications

Sierra‐Martin

Fernández-Barbero

2015

Soft Matter

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This paper reviews a wide set of theranostic applications based on the special properties associated with composite nanogels. The nanogels presented here are mostly hybridized with quantum dots, magnetic nanoparticles, and plasmonic metal noble nanoparticles. These inorganic components confer nanogels multifunctional properties that extend their applications from drug delivery systems to diagnosis and therapy. Nanogels can also be surface functionalized with specific ligands to achieve targeted therapy and reduce toxicity. This versatility makes hybrid nanogels very promising agents for imaging, diagnosis and treatment of cancer and other diseases.

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“…49 However, it is difficult to probe a nanoparticle surface’s chemistry and local environment. Recent work in our group has reported the development of aminobromomaleimide (ABM) and dithiolmalemide (DTM) fluorophores.…”

Section: Resultsmentioning

confidence: 99%

Reversibly Manipulating the Surface Chemistry of Polymeric Nanostructures via a “Grafting To” Approach Mediated by Nucleobase Interactions

Hua

Keogh

et al. 2017

Macromolecules

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“Grafting to” polymeric nanostructures or surfaces is a simple and versatile approach to achieve functionalization. Herein, we describe the formation of mixed polymer-grafted nanoparticles through a supramolecular “grafting to” method that exploits multiple hydrogen-bonding interactions between the thymine (T)-containing cores of preformed micelles and the complementary nucleobase adenine (A) of added diblock copolymers. To demonstrate this new “grafting to” approach, mixed-corona polymeric nanoparticles with different sizes were prepared by the addition of a series of complementary diblock copolymers containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) to a preformed micelle with a different coronal forming block, poly(4-acryloylmorpholine) (PNAM). PNIPAM chains were distributed throughout the corona and facilitated a fast and fully reversible size change of the resulting mixed-corona micelles upon heating. Through the introduction of an environmentally sensitive fluorophore, the reversible changes in nanoparticle size and coronal composition could be easily probed. Furthermore, preparation of mixed-corona micelles also enabled ligands, such as d-mannose, to be concealed and displayed on the micelle surface. This supramolecular “grafting to” approach provides a straightforward route to fabricate highly functionalized mixed polymeric nanostructures or surfaces with potential applications in targeted diagnosis or therapy and responsive surfaces.

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Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting

Cited by 54 publications

References 28 publications

To aggregate, or not to aggregate? considerations in the design and application of polymeric thermally-responsive nanoparticles

To aggregate, or not to aggregate? considerations in the design and application of polymeric thermally-responsive nanoparticles

Multifunctional hybrid nanogels for theranostic applications

Reversibly Manipulating the Surface Chemistry of Polymeric Nanostructures via a “Grafting To” Approach Mediated by Nucleobase Interactions

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