Polymer composite films based on citrus pectin for controlled delivery of Ceftriaxone

Badykova, L. A.; Фатыхов, А. А.; Mudarisova, R. Kh.

doi:10.1134/s1070363214100247

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…And almost all organo-hydrogels was observed to release 100% of Oxaliplatin in its structure within 10 h. Unlike Ceftriaxone release from organo-hydrogels, Oxaliplatin release reached 100% release rate within 1 day. Moreover some of the other reported material at literature was HAP-2 (porosity of 2% Hydroxyapatite) (34.78% Ceftriaxone), HAP-4 (49.65% Ceftriaxone), HAP-6 (64.65% Ceftriaxone), HAP-8 (75.01% Ceftriaxone) and HAP-10 (92.61% Ceftriaxone) [ 34 ], Citrus-Pectin [ 35 ] (97.2% Ceftriaxone), CP:PVA 1:02 (97.7% Ceftriaxone, 7 days), CP:PVA 1:04 (79.2% Ceftriaxone, 7 days), CP:PVA 1:06 (69.2% Ceftriaxone, 7 days) [ 35 ], chitosan nanoparticles (98.4%, pH4.5, Oxaliplatin) and chitosan nanoparticles (15.7%, pH7.4, Oxaliplatin) [ 14 ], poly-lactic-co-glycolic acid-oxaliplatin microspheres (100%, Oxaliplatin) [ 13 ], RG-503 (PLAGApolymer) (100%, Oxaliplatin), 10% PLAGAoligomer RG503 (90%, Oxaliplatin), RG503 (80%) and RG502 (20%, Oxaliplatin)[ 15 ], MWCNTPEGOxaliplatin (80%, Oxaliplatin, 7 days), MWCNTOxaliplatin (89% Oxaliplatin, 5 days)[ 36 ], so on. The highest cumulative ceftriaxone release from organogels was observed in organogels synthesized by GA crosslinker.…”

Section: Resultsmentioning

confidence: 99%

Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

2021

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In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107–115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.

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Section: Resultsmentioning

confidence: 99%

Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

2021

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“…Unlike Ceftriaxone release from organohydrogels, Oxaliplatin release reached 100% release rate within 1 day. Moreover some of the other reported material at literature was HAP-2 (porosity of 2% Hydroxyapatite)(34.78% Ceftriaxone), HAP-4 (49.65% Ceftriaxone), HAP-6 (64.65% Ceftriaxone), HAP-8 (75.01% Ceftriaxone) and HAP-10 (92.61% Ceftriaxone) [28], Citrus-Pectin (CP) (97.2% Ceftriaxone), CP:PVA 1:02 (97.7% Ceftriaxone, 7 days), CP:PVA 1:04 (79.2% Ceftriaxone, 7 days), CP:PVA 1:06 (69.2% Ceftriaxone, 7 days) [29], chitosan nanoparticles (98.4%, pH4.5, Oxaliplatin) and chitosan nanoparticles (15.7%, pH7.4, Oxaliplatin) [14], poly-lactic-co-glycolic acid-oxaliplatin microspheres (100%, Oxaliplatin) [13], RG-503 (PLAGApolymer) (100%, Oxaliplatin), 10% PLAGAoligomer RG503 (90%, Oxaliplatin), RG503 (80%) and RG502 (20%, Oxaliplatin) [15], MWCNTPEGOxaliplatin (80%, Oxaliplatin, 7 days), MWCNTOxaliplatin (89% Oxaliplatin, 5 days) [30], so on. The highest cumulative ceftriaxone release from organogels was observed in organogels synthesized by GA crosslinker.…”

Section: Ceftriaxone and Oxaliplatin Release Studiesmentioning

confidence: 99%

Application of poly (Agar-co-Glycerol-co-Sweet Almond Oil) based organohydrogels as a Drug Delivery Material

Dudu

Alpaslan

Aktaş

2021

Preprint

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In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organohydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (SAO). Organohydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organohydrogels were examined. In addition, Organohydrogels which loaded with Ceftriaxone (antibiotic) and Oxaliplatin (an anti-cancer agent), were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8), at 37° C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organohydrogels and values consistent with release results were found.

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“…The study [131] aimed to investigate the possibilities of complex formations between citrus pectin (CP) with antibiotic ceftriaxone (Ctx) and of the formation of model composite films. Polymer films that were capable of controlled ceftriaxone release have been prepared based on the citrus pectin mixture with polyvinyl alcohol (PVA).…”

Section: Pectin As Carriers For Drug Deliverymentioning

confidence: 99%

Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review

et al. 2018

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Pectin is a polymer with a core of alternating α-1,4-linked d-galacturonic acid and α-1,2-l-rhamnose units, as well as a variety of neutral sugars such as arabinose, galactose, and lesser amounts of other sugars. Currently, native pectins have been compared to modified ones due to the development of natural medicines and health products. In this review, the results of a study of the bioactivity of pectic polysaccharides, including its various pharmacological applications, such as its immunoregulatory, anti-inflammatory, hypoglycemic, antibacterial, antioxidant and antitumor activities, have been summarized. The potential of pectins to contribute to the enhancement of drug delivery systems has been observed.

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Polymer composite films based on citrus pectin for controlled delivery of Ceftriaxone

Cited by 7 publications

References 6 publications

Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

Application of poly (Agar-co-Glycerol-co-Sweet Almond Oil) based organohydrogels as a Drug Delivery Material

Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review

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