Polymer complexes. LXX. Synthesis, spectroscopic studies, thermal properties and antimicrobial activity of metal(II) polymer complexes

Abstract

Ni(II) or Co(II)). The structures of the polymer complexes were identified using elemental analysis, infrared and electronic spectra, molar conductance, magnetic susceptibility, X-ray diffraction and thermogravimetric analysis. The interaction between the polymer complexes and calf thymus DNA showed a hypochromism effect. HL and its polymer complexes were tested against bacterial and fungal species. Co(II) polymer complex 2 is the most effective against Klebsiella pneumoniae and is more active than penicillin. The results showed that Ni(II) polymer complex 5 is a good antibacterial agent against Staphylococcus aureus and Pseudomonas aeruginosa. Molecular docking was used to predict the binding between the monomer with the receptors of prostate cancer (PDB code: 2Q7L Hormone) and breast cancer (PDB code: 1JNX Gene regulation). Coats-Redfern and Horowitz-Metzger methods were applied for calculating the thermodynamic parameters of HL and its polymer complexes. The thermal activation energy of decomposition for HL is higher than that for the polymer complexes.

Polymer complexes. LXXI. Spectroscopic studies, thermal properties, DNA binding and antimicrobial activity of polymer complexes

“…The IR spectrum of monomer shows bands in the range of 3391–3255 cm −1 due to asymmetric and symmetric stretching vibrations of NH (hydrazone) group and intramolecular hydrogen bonding N‐H…O systems (Figure ). A strong band at ~ 1604 cm −1 can guide to assume the presence of C=N‐ of hydrazone structure through resonating phenomena . In the IR spectrum, υ(‐C=N‐NH, hydrazone) band of monomer disappear in polymer complexes (1, 2 and 4) but appear in polymer complex [Mn(HL) 2 (OCOCH 3 ) 2 ] n (3) (3382 cm −1 due to –C=N‐NH), also adding more evidence for the hydrazone and deprotonation of the hydrazone proton (C=N‐N‐) prior to coordination of nitrogen to the metal ion and it is supported to a great extent by the appearance of a new peak due to υ(M‐N) stretching frequency.…”

“…The room temperature magnetic moment of the cobalt(II) polymer complex (5.05 B.M.) is characteristic of high‐spin octahedral Co(II) polymer complex . IR spectrum of cobalt(II) polymer complex shows that the acetate group coordinate to Co(II) ion in a bidentate manner where the difference between the asymmetric and symmetric stretching vibrations of the acetate group is Δυ ≤ 180 cm −1 .…”

“…3‐Allyl‐5‐[(4‐nitrophenylazo)]‐2‐thioxothiazolidine‐4‐one (HL) monomer was synthesized by the well‐established standard method (Figure ) . The resulting solid of HL was recrystallized with ethanol and then dried in a vacuum desiccator over anhydrous calcium chloride.…”

“…They are the subject of large research works due to their applications as textile dye, pharmaceuticals and indicators . Azo dyes derived from heterocyclic amine or derivatives aniline containing nitrogen in their aromatic rings and their metal complexes have been receiving the attention of research groups due to their biological activities as antitumor, antibacterial and antifungal . These compounds are now in good demands as optical and conducting organic materials .…”

“…A literature survey shows subtle work to synthesis and characterization of rhodanine azo dyes, also their metal complexes which widely used in different fields such as biological studies, optical and electrical studies . Transition metal polymer complexes of allyl rhodanine azo compounds are a subject of current and growing interest and that may have numerous applications chemically allyl azo rhodanine containing oxygen, sulphur and nitrogen donor atoms are of great interest because of their great versatility as ligands, due to presence of several potential donor atoms, their ability and flexibility to coordinate in either deprotonated or neutral form.…”