Polymer‐Chain Encoding: Synthesis of Highly Complex Monomer Sequence Patterns by Using Automated Protocols

Chan‐Seng, Delphine; Zamfir, Mirela; Lutz, Jean‐François

doi:10.1002/ange.201206371

Cited by 22 publications

(19 citation statements)

References 42 publications

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“…ATRP is the most commonly used technique in their process [166,167,180], while NMP was also reported [175,177]. The precision in time-controlled addition also affects the precision insertion of the maleimides units, therefore robotic, automated protocols were shown to improve the experimental conditions [181]. Under such conditions, up to 8 nonoverlapping maleimide zones could be inserted within 100 styrene units, which corresponds to n 8 microstructure arrangements within a chain length of 100 when n kinds different maleimides are used.…”

Section: Sequence-controlled Alternating Copolymersmentioning

confidence: 99%

Recent advances in alternating copolymers: The synthesis, modification, and applications of precision polymers

Huang

Turner

2017

Polymer

110

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Alternating copolymers represent a special class of copolymers, in which the two comonomers copolymerize in a regular alternating sequence along the chain. Their interesting physical and chemical properties, as well as the underlying mechanism, have attracted significant attention in both academia and industry. The electron-donor benzylidene monomers-styrene and stilbene, readily form alternating copolymers with the electron-acceptor monomersmaleic anhydride and N-substituted maleimides. The rich chemistry of the substitution groups on these monomers offers enormous combinations for the synthesis of alternating copolymers for different applications. In this paper, we aim to provide a general overview of recent publications on the specific field of these benzylidene-containing alternating copolymers, and the emphasis is placed on the synthetic progress, structure-property relationships, and the applications of these copolymers.

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Section: Sequence-controlled Alternating Copolymersmentioning

confidence: 99%

Recent advances in alternating copolymers: The synthesis, modification, and applications of precision polymers

Huang

Turner

2017

Polymer

110

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“…This means that the minor monomer selectively propagates over the primarily existing monomer even though there is a big difference in the injected amounts of the comonomers. Lutz and co-workers [36][37][38][39][40][41][42][43][44] noticed the crossover propagation feature of the alternating copolymerization for achieving local functionalization of a polymer chain using RDRP (Figure 6a). In this approach, styrene or the derivative is polymerized with RDRP (ATRP or NMP), and a slight excess of an MI derivative is added to the growing chains during the RDRP for pinpoint insertion.…”

Section: Sequence-controlled Polymers M Ouchi and M Sawamotomentioning

confidence: 99%

Sequence-controlled polymers via reversible-deactivation radical polymerization

Ouchi

Sawamoto

2017

Polym J

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The development of reversible-deactivation radical polymerization (RDRP) has made a great contribution not only in controlling the molecular weight and terminal structures but also in the precise synthesis of copolymers. An additional design for controlled propagation via RDRP could lead to control of the order of repeating units, that is, the 'sequence control', which has been recognized as the ultimate control of precision polymerizations. In this review article, some concepts and methodologies are summarized for synthesizing sequence-controlled polymers based on RDRP.

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“…Hence, by the time‐controlled addition of MIs, it is possible to create polymers with complex microstructures in a one‐pot process 7. 11 The macromolecules synthesized by this process are donor homopolymers containing positionable functional MI “patches”. Of course, these copolymers are not perfectly sequence‐defined.…”

Section: Copolymers Of 3 With N‐substituted Maleimides[a]mentioning

confidence: 99%

Precision PEGylated Polymers Obtained by Sequence‐Controlled Copolymerization and Postpolymerization Modification

Srichan¹,

Mutlu²,

Badi³

et al. 2014

Angewandte Chemie

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Copolymers containing water-soluble poly(ethylene glycol) (PEG) side chains and precisely controlled functional microstructures were synthesized by sequence-controlled copolymerization of donor and acceptor comonomers, that is, styrene derivatives and N-substituted maleimides. Two routes were compared for the preparation of these structures: a) the direct use of a PEG-styrene macromonomer as a donor comonomer, and b) the use of an alkyne-functionalized styrenic comonomer, which was PEGylated by copper-catalyzed alkyne-azide cycloaddition after polymerization. The latter method was found to be the most versatile and enabled the synthesis of high-precision copolymers. For example, PEGylated copolymers containing precisely positioned fluorescent (e.g. pyrene), switchable (e.g. azobenzene), and reactive functionalities (e.g. an activated ester) were prepared.

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Polymer‐Chain Encoding: Synthesis of Highly Complex Monomer Sequence Patterns by Using Automated Protocols

Cited by 22 publications

References 42 publications

Recent advances in alternating copolymers: The synthesis, modification, and applications of precision polymers

Recent advances in alternating copolymers: The synthesis, modification, and applications of precision polymers

Sequence-controlled polymers via reversible-deactivation radical polymerization

Precision PEGylated Polymers Obtained by Sequence‐Controlled Copolymerization and Postpolymerization Modification

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