Polymer brush-based approaches for the development of infection-resistant surfaces

Hadjesfandiari, Narges; Yu, Kai; Mei, Yan; Kizhakkedathu, Jayachandran N.

doi:10.1039/c4tb00550c

Cited by 128 publications

(121 citation statements)

References 77 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…[15][16][17][18][19][20] These antibacterial surfaces can be constructed through two different methods: anti-adhesive coating to resist bacterial adhesion and bactericidal surface to kill contacting bacteria. Many kinds of anti-adhesive coatings have been designed and prepared to reduce bacterial adhesion.…”

Section: Wang Et Almentioning

confidence: 99%

Fabrication of nonfouling, bactericidal, and bacteria corpse release multifunctional surface through surface-initiated RAFT polymerization

Wang

Tang

et al. 2016

IJN

View full text Add to dashboard Cite

Section: Wang Et Almentioning

confidence: 99%

Fabrication of nonfouling, bactericidal, and bacteria corpse release multifunctional surface through surface-initiated RAFT polymerization

Wang

Tang

et al. 2016

IJN

View full text Add to dashboard Cite

“…2,3 As a result of the decreasing efficacy of available antibiotics, there is a critical need for new effective agents and bacteria-resistant medical implant/device surfaces. 4–6 Cationic antimicrobial peptides (AMPs) have gained research attention due to their broad spectrum of antibacterial activity, and lower susceptibility to resistance. 7 Antibacterial peptides owe their activity to the combination of ionizable nitrogenous moieties, which allow for the binding to the outer surface of the bacteria, and the lipophilic segment, which is able to insert into the cell membrane causing cell death through osmotic swelling and lysis.…”

Section: Introductionmentioning

confidence: 99%

Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency

et al. 2017

View full text Add to dashboard Cite

Cu(0)-mediated polymerization was employed to synthesize a library of structurally varied cationic polymers and their application as antibacterial peptide mimics was assessed. Eight platform polymers were first synthesized with low degrees of polymerization (DP) using (2-Boc-amino)ethyl acrylate as the monomer and either ethyl α-bromoisobutyrate or dodecyl 2-bromoisobutyrate as the initiator (thus providing hydrocarbon chain termini of C2 or C12, respectively). A two-step modification strategy was then employed to generate the final sixteen-member polymer library. Specifically, an initial deprotection was employed to reveal the primary amine cationic polymers, followed by guanylation. The biocidal activity of these cationic polymers was assessed against various strains of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Polymers having a short segment of guanidine units and a C12 hydrophobic terminus were shown to provide the broadest antimicrobial activity against the panel of isolates studied, with MIC values approaching those for Gram-positive targeting antibacterial peptides: daptomycin and vancomycin. The C12-terminated guanidine functional polymers were assayed against human red blood cells, and a concomitant increase in haemolysis was observed with decreasing DP. Cytotoxicity was tested against HEK293 and HepG2 cells, with the lowest DP C12-terminated polymer exhibiting minimal toxicity over the concentrations examined, except at the highest concentration. Membrane disruption was identified as the most probable mechanism of bacteria cell killing, as elucidated by membrane permeability testing against E. coli.

show abstract

“…Compared to the chemical methods of immobilization, gamma radiation induced grafting is advantageous since it is applicable to a wide variety of polymer–monomer combinations and does not require chemical initiators which leave residues behind as the impurity. The creation of polymer brushes on a polymer surface provides a unique opportunity to develop antifouling surfaces via grafting process . For instance, PEG or polyethylene oxide (PEO) brushes have been designed as antiadhesion layers that can be created on all the hydrophilic and hydrophobic surfaces .…”

Section: Strategies For Developing Antimicrobial Catheter Surfacementioning

confidence: 99%

Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances

Anjum¹,

Singh²,

Lepoittevin

et al. 2017

Global Challenges

View full text Add to dashboard Cite

Microbial burden associated with medical devices poses serious health challenges and is accountable for an increased number of deaths leading to enormous medical costs. Catheter‐associated urinary tract infections are the most common hospital‐acquired infections with enhanced patient morbidity. Quite often, catheter‐associated bacteriuria produces apparent adverse outcomes such as urosepsis and even death. Taking this into account, the methods to modify urinary catheters to control microbial infections with relevance to clinical drug resistance are systematically evaluated in this review. Technologies to restrict biofilm formation at initial stages by using functional nanomaterials are elucidated. The conventional methodology of using single therapeutic intervention for developing an antimicrobial catheter lacks clinically meaningful benefit. Therefore, catheter modification using naturally derived antimicrobials such as essential oils, curcumin, enzymes, and antimicrobial peptides in combination with synthetic antibiotics/nanoantibiotics is likely to exert sufficient inhibitory effect on uropathogens and is extensively discussed. Futuristic efforts in this area are projected here that demand clinical studies to address areas of uncertainty to avoid development of bacterial resistance to the new generation therapy with minimum discomfort to the patients.

show abstract

Polymer brush-based approaches for the development of infection-resistant surfaces

Cited by 128 publications

References 77 publications

Fabrication of nonfouling, bactericidal, and bacteria corpse release multifunctional surface through surface-initiated RAFT polymerization

Fabrication of nonfouling, bactericidal, and bacteria corpse release multifunctional surface through surface-initiated RAFT polymerization

Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency

Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances

Contact Info

Product

Resources

About