Polymer Blends Used for the Coating of Multiparticulates: Comparison of Aqueous and Organic Coating Techniques

Lecomte, Florence; Siepmann, Juergen; Walther, Mathias; MacRae, Ross J.; Bodmeier, Roland

doi:10.1023/b:pham.0000026443.71935.cb

Cited by 116 publications

(57 citation statements)

References 5 publications

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“…Thus, RL and L55 copolymer chains are highly entangled, and therefore, leaching out of L55 into the surrounding medium is minimized. Such behavior has been described before for film blends of ethyl cellulose and L55 prepared from organic solution (31). Additionally, the ionic interactions between the copolymers might also contribute to the prevention of leaching out of L55 during exposure to phosphate buffer pH 6.8.…”

Section: Investigation Of the Erosion Of Plain Copolymer Films And Fisupporting

confidence: 69%

Coatings of Eudragit® RL and L-55 Blends: Investigations on the Drug Release Mechanism

Wulff

Leopold

2015

AAPS PharmSciTech

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Abstract. In a previous study, generally lower drug release rates from RL:L55 blend coated pellets in neutral/basic release media than in acidic release media were reported. The aim of this study was to obtain information on the drug release mechanism of solid dosage forms coated with blends of Eudragit ® RL (RL) and Eudragit ® L-55 (L55). Swelling experiments with free films were analyzed spectroscopically and gravimetrically to identify the physicochemical cause for this release behavior. With Raman spectroscopy, the swelling of copolymer films could be monitored. IR spectroscopic investigations on RL:L55 blends immersed in media at pH 6.8 confirmed the formation of interpolyelectrolyte complexes (IPECs) that were not detectable after swelling in hydrochloric acid pH 1.2. Further investigations revealed that these IPECs decreased the extent of ion exchange between the quaternary ammonium groups of RL and the swelling media. This is presumably the reason for the previously reported decreased drug permeability of RL:L55 coatings in neutral/basic media as ion exchange is the determining factor in drug release from RL coated dosage forms. Gravimetric erosion studies confirmed that L55 was not leached out of the film blends during swelling in phosphate buffer pH 6.8. In contrast to all other investigated films, the 4:1 (RL:L55) blend showed an extensive swelling within 24 h at pH 6.8 which explains the reported sigmoidal release behavior of 4:1 blend coated pellets. These results help to understand the release behavior of RL:L55 blend coated solid dosage forms.KEY WORDS: enteric polymethacrylate; interpolyelectrolyte complex; ion exchange; polymer blend; quaternary polymethacrylate.

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Section: Investigation Of the Erosion Of Plain Copolymer Films And Fisupporting

confidence: 69%

Coatings of Eudragit® RL and L-55 Blends: Investigations on the Drug Release Mechanism

Wulff

Leopold

2015

AAPS PharmSciTech

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“…Apart from being used for the preparation of the core of monolithic matrices, polymer blending was also studied in the aim to modify the permeability characteristics of the film in solid dosage forms coated with cellulose esters (73)(74)(75)(76)(77)(78)(79). These studies demonstrated that the drug release kinetics can be modulated by altering the coating characteristics, and consequently the drug release mechanism, via the introduction of a "non-coating agent" in the film composition.…”

Section: The Need Of Innovative Materials For Intelligent Delivery Inmentioning

confidence: 99%

Novel Platforms for Oral Drug Delivery

et al. 2009

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The aim of this review is to provide the reader general and inspiring prospects on recent and promising fields of innovation in oral drug delivery. Nowadays, inventive drug delivery systems vary from geometrically modified and modular matrices, more close to "classic" pharmaceutical manufacturing processes, to futuristic bio micro-electro-mechanical systems (bioMEMS), based on manufacturing techniques borrowed from electronics and other fields. In these technologies new materials and creative solutions are essential designing intelligent drug delivery systems able to release the required drug at the proper body location with the correct release rate. In particular, oral drug delivery systems of the future are expected to have a significant impact on the treatment of diseases, such as AIDS, cancer, malaria, diabetes requiring complex and multi-drug therapies, as well as on the life of patients, whose age and/or health status make necessary a multiple pharmacological approach.

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“…[9] Further, blending of polymers has also been used to create films with tailored interfacial properties for controlling drug release from microparticles. [10,11] The unique benefit that blending affords has recently been applied to PEs in tandem with the LbL approach to tailor the physicochemical properties of surfaces, thus producing highly functional films and coatings with nanoscale dimensions and tailored interfacial properties assembled from aqueous solutions. Two distinct types of PE blends have been identified in the current literature.…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Blend Multilayers: A Versatile Route to Engineering Interfaces and Films

Quinn

Such

Quinn

et al. 2007

Adv Funct Materials

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The ability to reliably engineer surfaces with nanoscale precision is a rapidly developing field of research with applications ranging from biosensing and biomedical materials to antifouling and corrosion protection. The layer‐by‐layer (LbL) approach is a widely utilized method for engineering surfaces, in part because of the large array of polymeric materials that can be integrated and the diverse range of functionality that these materials afford. Herein, we discuss the LbL deposition of multicomponent ‘blend' solutions to form polyelectrolyte blend multilayer films and coatings. This approach is a versatile platform for enhancing film stability, incorporating a wide range of functional materials, controlling film morphology and material properties, and increasing biological response, thereby expanding the range of potential applications.

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Polymer Blends Used for the Coating of Multiparticulates: Comparison of Aqueous and Organic Coating Techniques

Abstract: The type of coating technique strongly affects the film microstructure and, thus, the release mechanism and rate from pellets coated with polymer blends.

Cited by 116 publications

References 5 publications

Coatings of Eudragit® RL and L-55 Blends: Investigations on the Drug Release Mechanism

Coatings of Eudragit® RL and L-55 Blends: Investigations on the Drug Release Mechanism

Novel Platforms for Oral Drug Delivery

Polyelectrolyte Blend Multilayers: A Versatile Route to Engineering Interfaces and Films

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