Polymer bioconjugates: Modern design concepts toward precision hybrid materials

Chen, Chaojian; Ng, David Y. W.; Weil, Tanja

doi:10.1016/j.progpolymsci.2020.101241

Cited by 140 publications

(103 citation statements)

References 470 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…Highly efficient and chemoselective secondary functionalization can be achieved when catechol chemistry is synergized with click chemistry, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), strain promoted azide-alkyne cycloaddition (SPAAC), temperature-dependent Diels-Alder reaction, and photoclick reaction (Figure 13c). [236,[263][264][265][266] For example, CuAAC chemistry has been incorporated into mussel-inspired citrate-based antimicrobial bioadhesives to enhance their wet adhesion strength (Figure 13d). [267] Very recently, taking advantage of the efficient, orthogonal, and metal-free SPAAC reaction, Huang group grafted a NO-generating molecule, organoselenium, and an endothelial progenitor cell-targeting peptide onto a stent modified with mussel-inspired peptide (Figure 13e).…”

Section: Immobilization Of Organic Speciesmentioning

confidence: 99%

Strategic Advances in Spatiotemporal Control of Bioinspired Phenolic Chemistries in Materials Science

Jia

Wen

Cheng

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Nature-inspired phenolic chemistries have substantially nourished the engineering of advanced materials for widespread applications in energy, catalysis, and biomedicine, among others. To achieve predictable yet adaptable material structures and properties, the spatial and/or temporal control over the phenolic chemistries per se is increasingly demanded. In this review, a systematic overview of recent strategical advances in the spatiotemporal control of phenolic chemistries in materials science is given. The chemical diversity and reactivity of catechols and polyphenols are first introduced as phenolic building blocks. With a main focus on catechols (especially dopamine), renewed insights into their mechanisms of polymerization/assembly, adhesion, and cohesion are provided. The conditions for tuning phenolic polymerization/assembly are also outlined. This paper focuses on the latest strategies for imparting controlled manipulation of phenolic chemistries in terms of many aspects: growth kinetics, chemical compositions and structures, dimensions and architectures, spatial patterns, and surface functionality. Finally, critical issues facing this field with perspectives delivered on future research are discussed. As envisaged, this review will provide helpful guidance to orchestrate state-of-the-art phenolic chemistries and materials science for producing materials with intended, application-oriented properties and functions.

show abstract

Section: Immobilization Of Organic Speciesmentioning

confidence: 99%

Strategic Advances in Spatiotemporal Control of Bioinspired Phenolic Chemistries in Materials Science

Jia

Wen

Cheng

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…(see, e.g., Refs. [ 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ] and references therein). Among enzymes, α-chymotrypsin (CT), a peptide bond cleaving serine protease enzyme, is one of the most widely investigated proteins in terms of its bioconjugation with a variety of polymers and applications in bioengineering [ 106 , 114 , 115 , 116 , 117 , 118 , 119 , 120 ].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Poly(N,N-diethylacrylamide-co-glycidyl methacrylate) Copolymers and Its Catalytically Active α-Chymotrypsin Bioconjugate with Enhanced Enzyme Stability

et al. 2021

View full text Add to dashboard Cite

Responsive (smart, intelligent, adaptive) polymers have been widely explored for a variety of advanced applications in recent years. The thermoresponsive poly(N,N-diethylacrylamide) (PDEAAm), which has a better biocompatibility than the widely investigated poly(N,N-isopropylacrylamide), has gained increased interest in recent years. In this paper, the successful synthesis, characterization, and bioconjugation of a novel thermoresponsive copolymer, poly(N,N-diethylacrylamide-co-glycidyl methacrylate) (P(DEAAm-co-GMA)), obtained by free radical copolymerization with various comonomer contents and monomer/initiator ratios are reported. It was found that all the investigated copolymers possess LCST-type thermoresponsive behavior with small extent of hysteresis, and the critical solution temperatures (CST), i.e., the cloud and clearing points, decrease linearly with increasing GMA content of these copolymers. The P(DEAAm-co-GMA) copolymer with pendant epoxy groups was found to conjugate efficiently with α-chymotrypsin in a direct, one-step reaction, leading to enzyme–polymer nanoparticle (EPNP) with average size of 56.9 nm. This EPNP also shows reversible thermoresponsive behavior with somewhat higher critical solution temperature than that of the unreacted P(DEAAm-co-GMA). Although the catalytic activity of the enzyme–polymer nanoconjugate is lower than that of the native enzyme, the results of the enzyme activity investigations prove that the pH and thermal stability of the enzyme is significantly enhanced by conjugation the with P(DEAAm-co-GMA) copolymer.

show abstract

“…Bioconjugation of biomolecules, such as proteins and nucleic acids, to polymers ex situ to generate hybrid materials to be used in either clinical or preclinical applications are outside of the scope of this review, and interested readers are directed to focused reviews on this topic. [14][15][16] While the term "bioorthogonal chemistry" is commonly associated with conjugation (bond-forming) reactions. I will discuss more broadly any reaction leading to a change in chemical structure that can be performed in a biological environment, including polymerization, cleavage and isomerism.…”

Section: Introductionmentioning

confidence: 99%

Shining a Light on Bioorthogonal Photochemistry for Polymer Science

Boase

2020

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Bioorthogonal chemistry is revolutionizing the fields of biological chemistry and nanomedicine, providing tools to actively probe and perturb native biochemical processes. Photochemistry provides the opportunity to actively and non‐invasively control bioorthogonal reactions, providing sophisticated optochemical tools. Despite the opportunities in bioorthogonal photochemistry, there remain many significant challenges to the clinical translation of current research. This review aims to provide an overview of these challenges and highlight recent examples from the literature that are providing revolutionary solutions to overcoming these barriers. It will highlight new photochemical systems that can be triggered by near infrared light in aqueous solutions and have been demonstrated to function in complex biological systems, including in living animals. It will cover diverse classes of photochemical reactions including photopolymerization, uncaging, conjugation, and photoswitching. The discussion will detail how new approaches are being integrated into polymers or highlight unexploited opportunities. This review intends to showcase how the unique synergy of bioorthogonal photochemistry and polymer science provides vast opportunities in the fields of biomaterials, nanomedicine, and theranostics. This will hopefully provide inspiration to material scientists to integrate bioorthogonal photochemistry into new adaptable materials and ensure translation to solve clinical challenges.

show abstract

Polymer bioconjugates: Modern design concepts toward precision hybrid materials

Cited by 140 publications

References 470 publications

Strategic Advances in Spatiotemporal Control of Bioinspired Phenolic Chemistries in Materials Science

Strategic Advances in Spatiotemporal Control of Bioinspired Phenolic Chemistries in Materials Science

Thermoresponsive Poly(N,N-diethylacrylamide-co-glycidyl methacrylate) Copolymers and Its Catalytically Active α-Chymotrypsin Bioconjugate with Enhanced Enzyme Stability

Shining a Light on Bioorthogonal Photochemistry for Polymer Science

Contact Info

Product

Resources

About