Polymer Biocompatibility

Porto, Isabel Cristina Celerino de Moraes

doi:10.5772/47786

Cited by 34 publications

(20 citation statements)

References 51 publications

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“…All polymers used in this study are well known and with proven biocompatibility. 21 Our attention was drawn to certain properties of almond oil. Fatty acid composition analysis made by Venkatachalam and Sathe indicated that oleic acid (C 18:1 ) is the main constituent of monounsaturated lipids (62%) while linoleic acid (C 18:2 ) is the major polyunsaturated fatty acid (29%).…”

Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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The purpose of the study was to investigate the stability and biopharmaceutical characteristics of ketoprofen, loaded in polymeric carriers, which were included into a bigel in a semisolid dosage form. The polymer carriers with in situ-included ketoprofen were obtained by emulsifier-free emulsion polymerization of the monomers in aqueous medium or a solution of the polymers used. The morphological characteristics of the carriers, the in vitro release and the photochemical stability of ketoprofen were evaluated. The model with optimal characteristics was included in a bigel formulation. The bigel was characterized in terms of pH, rheological behavior, spreadability, and in vitro drug release. Acute skin toxicity, antinociceptive activity, anti-inflammatory activity, and antihyperalgesic effects of the prepared bigel with ketoprofen-loaded polymer carrier were evaluated. The carriers of ketoprofen were characterized by a high yield and drug loading. The particle size distribution varied widely according to the polymer used, and a sustained release was provided for up to 6 hours. The polymer mixture poly(vinyl acetate) and hydroxypropyl cellulose as a drug carrier, alone or included in the bigel composition, improved the photostability of the drug compared with unprotected ketoprofen. The bigel with ketoprofen-loaded particles provided sustained release of the drug and had optimal rheological parameters. In vivo experiments on the bigel showed no skin inflammation or irritation. Four hours after its application, a well-defined analgesic, anti-inflammatory, and antihyperalgesic effect was registered. The polymer mixture of poly(vinyl acetate) and hydroxypropyl cellulose as a carrier of ketoprofen and the bigel in which it was included provided an enhanced photostability and sustained drug release.

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Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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“…Biocompatibility tests can be partitioned on three levels: in vitro (effects of materials on cultured cells), in vivo (tissue reactions after implantation, usually in animals), and preclinical tests (performance and reactions of biomaterials in normal clinical conditions after implantation in humans) [57]. They are assessing “the big three” biological effects: cytotoxicity (in vitro), sensitization (in vivo), and irritation (in vivo), which are common to biomaterials designed for medical devices.…”

Section: Biocompatibility: Concepts Standards and Assessmentmentioning

confidence: 99%

Biocompatibility of Polyimides: A Mini-Review

Constantin

Aflori

Damian³

et al. 2019

Materials

134

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Polyimides (PIs) represent a benchmark for high-performance polymers on the basis of a remarkable collection of valuable traits and accessible production pathways and therefore have incited serious attention from the ever-demanding medical field. Their characteristics make them suitable for service in hostile environments and purification or sterilization by robust methods, as requested by most biomedical applications. Even if PIs are generally regarded as “biocompatible”, proper analysis and understanding of their biocompatibility and safe use in biological systems deeply needed. This mini-review is designed to encompass some of the most robust available research on the biocompatibility of various commercial or noncommercial PIs and to comprehend their potential in the biomedical area. Therefore, it considers (i) the newest concepts in the field, (ii) the chemical, (iii) physical, or (iv) manufacturing elements of PIs that could affect the subsequent biocompatibility, and, last but not least, (v) in vitro and in vivo biocompatibility assessment and (vi) reachable clinical trials involving defined polyimide structures. The main conclusion is that various PIs have the capacity to accommodate in vivo conditions in which they are able to function for a long time and can be judiciously certified as biocompatible.

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“…Based on this, it can be affirmed that the obtained compounds were not toxic, since, none generated evidence of cellular lysis. Therefore, these could be used in more advanced or exhaustive in vitro tests, in order to put these materials in direct contact with primary cell cultures or cell lines; Or in vivo experiments with experimental animals, as these results give indications of their potential biocompatibility 25,32,33 . This obtained biocompatibility is a relevant result, since for this research, these copolymers will serve as an anchor point for the insertion of polysaccharides such as chitosan, hyaluronic acid and alginate, thus leaving evidence that new biocompatible compounds derived from these Which are being studied in this research.…”

Section: Cytotoxic Studiesmentioning

confidence: 99%

Intelligent copolymers based on poly (N-isopropylacrylamide) PNIPAm with potential use in biomedical applications. Part i: PNIPAm functionalization with 3-butenoic acid and piperazine

Carrero

Posada

Sabino

2018

IJAMB

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The synthesis and characterization of the thermosensitive copolymers based on Poly (N-Isopropylacrylamide) (PNIPAm) and 3-butenoic acid and functionalized with piperazine was carried out. The free radical polymerization of the PNIPA copolymer with 3-butenoic acid was performed under microwave radiation. After obtaining this copolymer, the carboxyl groups present in the copolymer chain were activated with 1-ethyl- (3-3-dimethylaminopropyl) carbodiimide in the presence of N-hydroxysuccinimide, improving its reactivity to incorporate the piperazine through its amino group. The characterization consisted: differential scanning calorimetric and ultraviolet-visible spectrophotometry to determine the LCST phase transition temperature, ranging from (30-35)°C. Structurally it was analyzed by infrared spectroscopy. A morphological analysis was performed using scanning electron microscopy, after simulating an injectable process, with the objective to observe internally the porosity and interconnectivity. The biocompatibility was evaluated through hemocompatibility tests and it was observed that the copolymers obtained were not cytotoxic. In base of the results, the chemical structure of these new copolymers confers a functionality that allows them to serve as nuclei to graft other molecules, such as polysaccharides. Then, the results obtained on the LCST temperature, porosity, interconnected pore network morphology, the ability to be injectable and the biocompatible nature of these copolymers are indicative that these new synthetic biomaterials have the potential to be used in biomedical, pharmacological and for tissue engineering. Also, once their biocompatibility was demonstrate, they may serve to generate interesting compounds having chemical anchor points for the possible addition of polysaccharides using insertion reactions, thereby generating graft copolymers with potential use in biomedical applications.

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Polymer Biocompatibility

Cited by 34 publications

References 51 publications

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Biocompatibility of Polyimides: A Mini-Review

Intelligent copolymers based on poly (N-isopropylacrylamide) PNIPAm with potential use in biomedical applications. Part i: PNIPAm functionalization with 3-butenoic acid and piperazine

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