Polymer: Bioceramic composites optimization by tetracycline addition

Pataro, André L.; Oliveira, Michele F.; Teixeira, Karina Imaculada Rosa; Turchetti-Maia, R.M.M.; Lopes, Míriam Teresa Paz; Wykrota, Francisco H.L.; Sinisterra, Rubén D.; Cortés, María Esperanza

doi:10.1016/j.ijpharm.2006.11.038

Cited by 14 publications

(8 citation statements)

References 27 publications

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“…They were both composed of porous block structure. However, the porous structure of the coating may be beneficial to the initiation of bone formation, providing abundant site for the growth of osseous tissue [17]. Compared to HA coating, SAHA coating was more compact and uniform.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of hydroxyapatite/stearic acid composite coating and corrosion behavior of coated magnesium alloy

Zhang¹,

Li²,

Li³

et al. 2012

Materials Letters

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Section: Resultsmentioning

confidence: 99%

Fabrication of hydroxyapatite/stearic acid composite coating and corrosion behavior of coated magnesium alloy

Zhang¹,

Li²,

Li³

et al. 2012

Materials Letters

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“…145 Scientists have also coated non-degradable implants with heparin and synthetic thrombin receptor agonist to shorten the inflammatory FBR, since they functions to bind to regulators of coagulation and complement activation. 80,146–153 Also, anti-inflammatory coatings previously reported to reduce neutrophil recruitment and FBR upon implantation of non-biodegradable implants include superoxide dismutase mimetics, 154 interleukin-1 receptor antagonist, 155 curcumin, 156–158 and vitamin E. 159 …”

Section: Efforts To Mitigate Fbrmentioning

confidence: 99%

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Amini

Wallace

Nukavarapu

2011

J Long Term Eff Med Implants

140

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Presently, orthopedic and oral/maxillofacial implants represent a combined $2.8 billion market, a figure expected to experience significant and continued growth. Although traditional permanent implants have been proved clinically efficacious, they are also associated with several drawbacks, including secondary revision and removal surgeries. Non-permanent, biodegradable implants offer a promising alternative for patients, as they provide temporary support and degrade at a rate matching tissue formation, and thus, eliminate the need for secondary surgeries. These implants have been in clinical use for nearly 25 years, competing directly with, or maybe even exceeding, the performance of permanent implants. The initial implantation of biodegradable materials, as with permanent materials, mounts an acute host inflammatory response. Over time, the implant degradation profile and possible degradation product toxicity mediate long-term biodegradable implant-induced inflammation. However, unlike permanent implants, this inflammation is likely to cease once the material disappears. Implant-mediated inflammation is a critical determinant for implant success. Thus, for the development of a proactive biodegradable implant that has the ability to promote optimal bone regeneration and minimal detrimental inflammation, a thorough understanding of short- and long-term inflammatory events is required. Here, we discuss an array of biodegradable orthopedic implants, their associated short- and long- term inflammatory effects, and methods to mediate these inflammatory events.

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“…Similarly, the addition of demineralized bone particles to PLGA was shown to lessen the inflammation in the vicinity of PLGA and reduce the fibrous tissue encapsulation and foreign body giant cell response [32]. The same effect of increased biocompatibility of PLGA was observed upon admixing an antibiotic, tetracycline, to it [33]. The buffered media, the mild dissolution of alkaline HAP and the slow degradation of PLGA, likewise, mitigate the acidifying effect of sole PLGA dissolution and render the particles “likable” to the cells.…”

Section: Resultsmentioning

confidence: 99%

Osteogenic and antimicrobial nanoparticulate calcium phosphate and poly-(d,l-lactide-co-glycolide) powders for the treatment of osteomyelitis

Uskoković

Hoover

Vukomanović

et al. 2013

Materials Science and Engineering: C

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Development of a material for simultaneous sustained and localized delivery of antibiotics and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands for an important clinical need. In this work, a comparative analysis of the bacterial and osteoblastic cell response to two different nanoparticulate carriers of clindamycin, an antibiotic commonly prescribed in the treatment of bone infection, one composed of calcium phosphate and the other comprising poly-(D,L-lactide-co-glycolide)-coated calcium phosphate, was carried out. Three different non-cytotoxic phases of calcium phosphate, exhibiting dissolution and drug release profiles in the range of one week to two months to one year, respectively, were included in the analysis: monetite, amorphous calcium phosphate and hydroxyapatite. Spherical morphologies and narrow size distribution of both types of nanopowders were confirmed in transmission and scanning electron microscopic analyses. The antibiotic-containing powders exhibited sustained drug release contingent upon the degradation rate of the carrier. Assessment of the antibacterial performance of the antibiotic-encapsulated powders against Staphylococcus aureus, the most common pathogen isolated from infected bone, yielded satisfactory results both in broths and on blood agar plates for all the analyzed powders. In contrast, no cytotoxic behavior was detected upon the incubation of the antibiotic powders with the osteoblastic MC3T3-E1 cell line for up to three weeks. The cells were shown to engage in a close contact with the antibiotic-containing particles, irrespective of their internal or surface phase composition, polymeric or mineral. At the same time, both types of particles upregulated the expression of osteogenic markers osteocalcin, osteopontin, Runx2 and protocollagen type I, suggesting their ability to promote osteogenesis and enhance remineralization of the infected site in addition to eliminating the bacterial source of infection.

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Polymer: Bioceramic composites optimization by tetracycline addition

Cited by 14 publications

References 27 publications

Fabrication of hydroxyapatite/stearic acid composite coating and corrosion behavior of coated magnesium alloy

Fabrication of hydroxyapatite/stearic acid composite coating and corrosion behavior of coated magnesium alloy

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Osteogenic and antimicrobial nanoparticulate calcium phosphate and poly-(d,l-lactide-co-glycolide) powders for the treatment of osteomyelitis

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