Polymer-Based Graphene Derivatives and Microwave-Assisted Silver Nanoparticles Decoration as a Potential Antibacterial Agent

Nicosia, Angelo; Vento, Fabiana; Pellegrino, Anna Lucia; Ranc, Václav; Piperno, Anna; Mazzaglia, Antonino; Mineo, Placido

doi:10.3390/nano10112269

Cited by 20 publications

(10 citation statements)

References 68 publications

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“…GMs loaded with silver nanoparticles (AgNPs) are also used as bone tissue repair materials due to their antibacterial activity, especially in the treatment of bone defects caused by bone infection (Liao et al, 2019;Nicosia et al, 2020;Weng et al, 2020). Silver ions and GO can play an antibacterial effect together (Dubey et al, 2018).…”

Section: Combined With Metal Materialsmentioning

confidence: 99%

Osteoinductive and antimicrobial mechanisms of graphene‐based materials for enhancing bone tissue engineering

Zou

Jiang

et al. 2021

J Tissue Eng Regen Med

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Graphene-based materials (GMs) have great application prospects in bone tissue engineering due to their osteoinductive ability and antimicrobial activity. GMs induce osteogenic differentiation through several mechanisms and pathways in bone tissue engineering. First of all, the surface and high hardness of the porous folds of graphene or graphene oxide (GO) can generate mechanical stimulation to initiate a cascade of reactions that promote osteogenic differentiation without any chemical inducers. In addition, change of the extracellular matrix (ECM), regulation of macrophage polarization, the oncostatin M (OSM) signaling pathway, the MAPK signaling pathway, the BMP signaling pathway, the Wnt/β-catenin signaling pathway, and other pathways are involved in GMs' regulation of osteogenesis. In bone tissue engineering, GMs prevent the formation of microbial biofilms mainly through preventing microbial adhesion and killing them. The former is mainly achieved by reducing surface free energy (SFE) and increasing hydrophobicity. The latter mainly includes oxidative stress and photothermal/photodynamic effects.Graphene and its derivatives (GDs) are mainly combined with bioactive ceramic materials, metal materials and macromolecular polymers to play an antimicrobial effect in bone tissue engineering. Concentration, number of layers, and type of GDs often affect the antimicrobial activity of GMs. In this paper, we reviewed relevant osteoinductive and antimicrobial mechanisms of GMs and their applications in bone tissue engineering.

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Section: Combined With Metal Materialsmentioning

confidence: 99%

Osteoinductive and antimicrobial mechanisms of graphene‐based materials for enhancing bone tissue engineering

Zou

Jiang

et al. 2021

J Tissue Eng Regen Med

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“…These unique properties of graphene and its derivatives have made these nanostructured materials suitable for various biological and medical applications [168] including anti-pathogenic applications [169] , [170] , [171] , [172] , [173] , [174] , [175] , [176] , [177] , biosensors [178] , [179] , [180] , [181] , [182] , [183] , [184] , bioimaging [185] , [186] , [187] , [188] , [189] , [190] , [191] , [192] , tissue engineering [193] , [194] , [195] , [196] , drug delivery [197] , [198] , [199] , [200] , [201] . Therefore, the interactions between graphene materials and viruses should be of great interest.…”

Section: Graphene-based Materialsmentioning

confidence: 99%

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Seifi

Kamali

2021

Medicine in Drug Discovery

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Coronavirus disease-2019 has been one of the most challenging global epidemics of modern times with a large number of casualties combined with economic hardships across the world. Considering that there is still no definitive cure for the recent viral crisis, this article provides a review of nanomaterials with antiviral activity, with an emphasis on graphene and its derivatives, including graphene oxide, reduced graphene oxide and graphene quantum dots. The possible interactions between surfaces of such nanostructured materials with coronaviruses are discussed. The antiviral mechanisms of graphene materials can be related to events such as the inactivation of virus and/or the host cell receptor, electrostatic trapping and physico-chemical destruction of viral species. These effects can be enhanced by functionalization and/or decoration of carbons with species that enhances graphene-virus interactions. The low-cost and large-scale preparation of graphene materials with enhanced antiviral performances is an interesting research-direction to be explored.

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“…[160][161][162][163][164][165][166][167][168][169][170][171][172][173][174] These unique properties of graphene and its derivatives have made these nanostructured materials suitable for various biological and medical applications, including antipathogenic applications. [175][176][177][178][179][180][181] In order to cope with the current COVID-19 pandemic, It should be mentioned that the antibacterial and antiviral activity of graphene or graphene-based nanomaterials can be explored based on various effects, including membrane, oxidative, and photothermal stresses as well as charge transfer, and the entrapment effect of graphene materials on various bacterial species. [182,183] One important aspect is the interactions between the virus and graphene-based materials.…”

Section: Inactivation Strategies Of the Virus Before Entry In The Host Cellmentioning

confidence: 99%

Nanotechnology: A Potential Weapon to Fight against COVID‐19

Tiwari

Mishra

Pandey

et al. 2021

Part & Part Syst Charact

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the phylogenetic and taxonomical finding on February 11, the coronavirus (COV) study group (CGS) of the International Committee on Virus Taxonomy (ICTV) designated the virus as SARS-CoV-2. [1] The same day, the director general of the World Health Organization (WHO) designated the disease caused by SARS-CoV-2 "coronavirus disease 2019" (COVID-19). The WHO declared COVID-19 a pandemic On March 11, 2020. Globally as of June 2021, 179 686 071 confirmed cases of COVID-19, including 3 899 172 deaths, reported by WHO. [2] Reducing the burden of COVID-19 infection by developing vaccines and antiviral drugs is still a big challenge for researchers and clinicians.Nowadays, nanotechnology is a promising player in the scientific and medical fields with many applications. [3,4] A new dimension has been opened by the functionally tunable nanosized materials for industrial, biomedical, and scientific purposes, which provides a set of techniques that allow the manipulation of structural and functional properties on a microscale. [5,6] Nanotechnology is kindred with the biomedicinal involvement of nanoparticles (NPs), which are not only used as the backbone in the vaccine to formulate "nanovaccines," nanomaterial-based antiviral agents, disinfectants; which inhibit the multiplication within the host or inactivate them outside the host, but also the application of designed nanorobots to detect and repairs of tissue defects at the cellular level. [7,8] Unlike the conventional drug formulations, which typically circulate throughout the entire body parts, nanoparticles may target a desired part of the body as a targeted drug delivery vehicle. Compared to conventional vaccines, nanovaccines or surface-functionalized nanoparticles can be designed, explicitly targeting lymphatic organs and immune cells to provoke better immune responses. Moreover, the localized infections are challenging to be treated by the conventional vaccines but can be treated by the nanovaccines with specific cells or organ-targeting molecules. In some cases, the nanobased settings are applied to enhance the solubility of hydrophobic compounds. These systems are helpful to protect the antigens from degradation and stabilize a large number of therapeutic biomolecules, such as peptides, proteins, and nucleic acids on the substrate. [9] Viral infections, particularly COVID-19, have posed a severe threat to public health globally because of their wide-sphered distribution and their potent ability to change the genetic makeup. [10] Unfortunately, viruses have adopted various alternative tacticsThe COVID-19 infections have posed an unprecedented global health emergency, with nearly three million deaths to date, and have caused substantial economic loss globally. Hence, an urgent exploration of effective and safe diagnostic/therapeutic approaches for minimizing the threat of this highly pathogenic coronavirus infection is needed. As an alternative to conventional diagnosis and antiviral agents, nanomaterials have a great potential to cope with the current or even futu...

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Polymer-Based Graphene Derivatives and Microwave-Assisted Silver Nanoparticles Decoration as a Potential Antibacterial Agent

Cited by 20 publications

References 68 publications

Osteoinductive and antimicrobial mechanisms of graphene‐based materials for enhancing bone tissue engineering

Osteoinductive and antimicrobial mechanisms of graphene‐based materials for enhancing bone tissue engineering

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Nanotechnology: A Potential Weapon to Fight against COVID‐19

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