Polymer‐Based Delivery Systems for Oral Delivery of Peptides and Proteins

Sarmento, Bruno; Ferreira, Domingos; Vasconcelos, Teófilo

doi:10.1002/9780470688397.ch11

Cited by 9 publications

(5 citation statements)

References 132 publications

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“…After treating diabetic rats, nanoparticles synthesized with dextran and coated with chitosan revealed a sustainedrelease profile and dramatically increased the hypoglycemic impact of insulin. Insulin encapsulation in vitamin B 12coated dextran nanoparticles has been proposed as a way to supplement diabetes treatment by using increased insulin absorption via vitamin B 12 intrinsic factor receptor ligand-mediated endocytosis through leukocytes in the gut (90)(91)(92).…”

Section: Polymer-based Insulin Nanoparticlesmentioning

confidence: 99%

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Saha

Sultana

Yesmin

et al. 2021

Avicenna J Pharm Res

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Diabetes is one of the major medical problems in the world. The discovery of insulin was a milestone in the history of medical science. This legendary invention has completed 100 years of its journey. Through this 100-year journey, many important events have taken place, and many modifications have been made to make it convenient for commercialization and patient compliance. After the antidiabetic activity of the pancreatic extract was discovered, the bovine and pork insulin came into use. Then, recombinant human insulin was discovered. Now long-acting to rapid-acting insulin forms are available (e.g., insulin pens, insulin pumps, and the like), and different systems are in use to deliver them to the body, but all these insulins are in invasive dosage forms and have some disadvantages, too. As we are using the oral form of most medicines, we prefer the oral form of insulin. Therefore, the concern is now to develop the oral dosage form of insulin. Some proposed oral dosage forms are at different stages of the clinical trial such as classical dosage forms, enzyme inhibitors, unnatural amino acids, nanoparticles, cell-penetrating peptides, and so on. Since the oral forms of insulin create some limitations and confusion, further research is required to solve these problems. Accordingly, the aim of the review was to predict the possibility of developing marketable oral insulin.

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Section: Polymer-based Insulin Nanoparticlesmentioning

confidence: 99%

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Saha

Sultana

Yesmin

et al. 2021

Avicenna J Pharm Res

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“…The TJs must be reversibly opened by chemically modifying the nanomaterial using permeation enhancers, such as chitosan, polyacrylate, and thiolated polymers (anionic and cationic polymers) [23]. Thus, the paracellular pathway mainly transports hydrophilic drugs [3,6]. A recent study used a cationic cyclodextrin-polyethylenimine 2k conjugate complexed with anionic mRNA encoding HIV gp120 to open TJs and enhance the paracellular transport of the nanomaterial [24].…”

Section: Transport Mechanismsmentioning

confidence: 99%

“…In fact, nanomaterials provide a stable biocompatible environment to encapsulate drugs, promoting their controlled release and efficient absorption [3,4]. They also improve the duration of the therapeutic effects and minimize adverse effects by driving drugs toward the site of action and increasing the concentration of a drug in the area of pathology in a specific way [5,6]. Depending on the accumulation of the delivery system in the tissue, cell, or in a specific subcellular compartment of interest, targeting approaches can be primary, secondary, or tertiary, respectively [7].…”

Section: Introductionmentioning

confidence: 99%

Strategies for the enhanced intracellular delivery of nanomaterials

Azevedo

Macedo

Sarmento

2018

Drug Discovery Today

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The intracellular delivery of nanomaterials and drugs has been attracting increasing research interest, mainly because of their important effects and functions in several organelles. Targeting specific organelles can help treat or decrease the symptoms of diabetes, cancer, infectious, and autoimmune diseases. Tuning biological and chemical properties enables the creation of functionalized nanomaterials with enhanced intracellular uptake, ability to escape premature lysosome degradation, and to reach a specific target. Here, we provide an update of recent advances in the intracellular delivery mechanisms that could help drugs reach their target more efficiently.

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“…Polymerbased delivery systems have been pro posed as valid approaches to provide successful systems to formulate proteins and we have a solid knowledge of the role of polymeric systems and their interaction with protein drugs [14]. In par ticular, chitosanbased delivery systems have been proposed to provide favorable and protective con ditions to deliver biopharmaceuticals.…”

Section: Polymeric Nanoparticles Chitosan and Beyondmentioning

confidence: 99%

Research Spotlight: Nanomedicines for Delivery of Therapeutic Proteins and Biopharmaceuticals

Sarmento

2010

Therapeutic Delivery

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Biopharmaceuticals are a class of therapeutics including recombinant therapeutic proteins, engineered antibodies and genetic material. They are attractive from a medical point of view, but technologically they face major challenges. The delivery of biopharmaceuticals still prevents them from reaching their maximum pharmacodynamic potential, owing to their physicochemical properties, poor stability, permeability and biodistribution. In our research group we have been involved with inter-related projects that intend to optimize strategies to improve the bioavailability of biopharmaceutical drugs after administration. One of the most employed drugs has been insulin, the oldest therapeutic protein, as well as siRNA and gene silencing genetic material. We are interested in formulating such drugs in polymeric nanoparticles, because they encompass an array of advantages compared with classical dosage forms. We also look for tools to correlate in vitro and in vivo absorption rates of biopharmaceuticals, in a rational chronologic sequence of manufacturing parameters, preclinical assessments and requirements for marketing approval.

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Polymer‐Based Delivery Systems for Oral Delivery of Peptides and Proteins

Cited by 9 publications

References 132 publications

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Strategies for the enhanced intracellular delivery of nanomaterials

Research Spotlight: Nanomedicines for Delivery of Therapeutic Proteins and Biopharmaceuticals

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