Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration

Pires, Patrícia C.; Mascarenhas-Melo, Filipa; Pedrosa, Kelly; Lopes, Daniela; Lopes, Joana; Macário-Soares, Ana; Peixoto, Diana; Giram, Prabhanjan S.; Veiga, Francisco; Paiva‐Santos, Ana Cláudia

doi:10.1016/j.eurpolymj.2023.111868

Cited by 76 publications

(45 citation statements)

References 103 publications

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“…In hydrolytic degradation, numerous hydrolytically labile bonds such as anhydride, ortho-ester, ester, urea, urethane/carbonate, and amide will undergo degradation under physiological conditions. Aliphatic polyesters biodegrade through cleavage of the ester bonds in the polymer backbone by water, resulting in diffusion and clearance of monomers and oligomers. , Enzymes secreted from macrophages, such as esterases and lipases, also participate in the degradation process. Inflammatory cells (macrophages and neutrophils) can release reactive agents, e.g., superoxide and hydrogen peroxide, which cause oxidative degradation .…”

Section: Biodegradationmentioning

confidence: 99%

Incorporation of Controlled Release Systems Improves the Functionality of Biodegradable 3D Printed Cardiovascular Implants

Kabirian,

Mozafari,

Mela

et al. 2023

ACS Biomater. Sci. Eng.

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New horizons in cardiovascular research are opened by using 3D printing for biodegradable implants. This additive manufacturing approach allows the design and fabrication of complex structures according to the patient’s imaging data in an accurate, reproducible, cost-effective, and quick manner. Acellular cardiovascular implants produced from biodegradable materials have the potential to provide enough support for in situ tissue regeneration while gradually being replaced by neo-autologous tissue. Subsequently, they have the potential to prevent long-term complications. In this Review, we discuss the current status of 3D printing applications in the development of biodegradable cardiovascular implants with a focus on design, biomaterial selection, fabrication methods, and advantages of implantable controlled release systems. Moreover, we delve into the intricate challenges that accompany the clinical translation of these groundbreaking innovations, presenting a glimpse of potential solutions poised to enable the realization of these technologies in the realm of cardiovascular medicine.

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Section: Biodegradationmentioning

confidence: 99%

Incorporation of Controlled Release Systems Improves the Functionality of Biodegradable 3D Printed Cardiovascular Implants

Kabirian,

Mozafari,

Mela

et al. 2023

ACS Biomater. Sci. Eng.

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“…PVP is a synthetic polymer used for many years as a biomaterial or component to medicinal formulations, such as a blood plasma expander and a replacement for vitreous fluid. It also has strong biocompatibility . Combining natural and synthetic polymers produces a new, more desired material with better mechanical properties and lower cost.…”

Section: Introductionmentioning

confidence: 99%

“…It also has strong biocompatibility. 15 Combining natural and synthetic polymers produces a new, more desired material with better mechanical properties and lower cost. CS and PVP mixtures have already been investigated for their potential use in biomedical applications, biocompatibility, and antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of the Extraction of Cu(II) and Fe(II) Ions Using Chitosan and Modified Chitosan/Polyvinylpyrrolidone Adsorptive Membranes: Adsorption, Kinetic, and Thermodynamic Study

Arora

Jangid

Srivastava

et al. 2023

ACS Appl. Polym. Mater.

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The current work examined chitosan's adsorption capabilities for removing Cu(II) and Fe(II) ions from the aqueous phase in a batch equilibrium system. The membranes were prepared using the leaching-out method. The effects of the adsorbent's initial pH, concentration, temperature, and dose on adsorption were examined. Adsorption tests were conducted at temperatures ranging from 15 to 45 °C and initial concentration ranges of 20−400 mg/L. The observations from the adsorption isotherms fitted the Langmuir and Freundlich model adequately. The nonlinear form of the pseudo-first-order model was followed by the kinetics of Cu(II) and Fe(II) on chitosan, and the model parameters were reliably obtained. The endothermic and spontaneous character of Cu(II) and Fe(II) adsorption on chitosan adsorbents was verified by the computed negative values of standard Gibbs free energy and positive enthalpy changes. Finally, chitosan (CS) showed to be an efficient adsorbent for the removal of Cu(II) and Fe(II) ions due to its high adsorption capacity for Cu(II), which was 182.15 mg/g for C1, 331.28 mg/g for C2, and 384.31 mg/g for C3, and Fe(II), which was 201.67 mg/g for C1, 352.53 mg/g for C2, and 315.8 mg/g for C3 (where C1 is the CS membrane, C2 is the CS/silica membrane, and C3 is the CS/polyvinylpyrrolidone membrane).

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“…Natural and synthetic biopolymers, classified into poly(nucleic acids), proteins, polysaccharides, polyhydroxyalkanoates, and polyphenols, are considered the most dominant biomolecules used in pharmaceutical and clinical medicine applications. [1][2][3] Biopolymers are produced by living organisms, such as plants/algae, bacteria, and other microbial systems, or can be action, high adsorption capacity, as well as remarkable chelation ability. [1,18] Due to its various functional groups, such as hydroxyl, amino, and carboxylic acid, CS is suitable for further chemical modification.…”

Section: Introductionmentioning

confidence: 99%

“…Natural and synthetic biopolymers, classified into poly(nucleic acids), proteins, polysaccharides, polyhydroxyalkanoates, and polyphenols, are considered the most dominant biomolecules used in pharmaceutical and clinical medicine applications. [ 1–3 ] Biopolymers are produced by living organisms, such as plants/algae, bacteria, and other microbial systems, or can be chemically extracted from basic biological systems. [ 1,4 ] Due to their bio‐origin and high oxygen and nitrogen contents in their chain backbone, biopolymers are highly biodegradable and can be easily converted to carbon dioxide, biomass, water, and other natural derivatives via simple biological processes.…”

Section: Introductionmentioning

confidence: 99%

Capitalization of Graphene/Chitosan Nanocomposites as Intriguing Vehicles for Targeted Anti‐Cancer Drug Delivery

Kourti

Theodorakis

Σκούρας

et al. 2023

Advanced Therapeutics

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The effective combination of various polysaccharides with graphene derivatives towards the formation of nanocomposites has gained enormous interest for a number of emerging biological and biomedical applications. The intriguing properties of the individual materials are further improved upon the realization of (nano)composites, thus providing new insights and property enhancement in terms of durability, flexibility, biocompatibility, low‐toxicity, and antibacterial/antimicrobial behavior. Therefore, novel (nano)composite agents have been prepared and investigated to serve as ideal carriers or scaffold materials in regenerative medicine, biosensing, disease diagnosis and treatment, drug delivery, as well as stem cell and tissue engineering applications. This topical review summarizes the most recent studies published during the last quinquennium (2018 – 2022), on the development of anticancer drug delivery systems (DDSs) based on graphene/chitosan nanocomposites. The followed synthetic routes and the integrated properties of the composite materials are analyzed, discussing the impact of their utilization in the field of drug delivery for the treatment of various cancer types. The prospects and future research trends in the field are also discussed.This article is protected by copyright. All rights reserved

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Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration

Cited by 76 publications

References 103 publications

Incorporation of Controlled Release Systems Improves the Functionality of Biodegradable 3D Printed Cardiovascular Implants

Incorporation of Controlled Release Systems Improves the Functionality of Biodegradable 3D Printed Cardiovascular Implants

Comparative Study of the Extraction of Cu(II) and Fe(II) Ions Using Chitosan and Modified Chitosan/Polyvinylpyrrolidone Adsorptive Membranes: Adsorption, Kinetic, and Thermodynamic Study

Capitalization of Graphene/Chitosan Nanocomposites as Intriguing Vehicles for Targeted Anti‐Cancer Drug Delivery

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