Polylactones synthesis by enzymatic ring opening polymerization in flow

Adhami, Wissal; Bakkour, Youssef; Rolando, Christian

doi:10.1016/j.polymer.2021.124040

Cited by 16 publications

(17 citation statements)

References 49 publications

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“…It was also stated that the multiple reuse cycles of N435 would be unattainable if leaching of CALB occurred due to physical desorption during polymer synthesis or if it was submitted to high mechanical shear (e.g., intense mechanical stirring). Very recently, Adhami et al [57] conducted eROP of lactones to produce PCL and poly(δ-valerolactone) (PVL) using N435 in a flow tubular reactor. Due to the decreased reaction time of each cycle, the researchers synthesized PCL in toluene at 70 • C while reusing the enzyme more than ten times.…”

Section: Type and Characteristics Of The Used Enzyme For Pla Enzymatic Polymerizationmentioning

confidence: 99%

Enzymatic Polymerization as a Green Approach to Synthesizing Bio-Based Polyesters

Gkountela

Vouyiouka

2022

Macromol

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Given the fossil fuel crisis and the steady consumption of finite resources, the use of green polymers is becoming necessary. However, the term “green” describes materials that present green properties (such as biological origin and/or biodegradability) and are produced via sustainable processes conducted under mild conditions and not requiring the use of chemical catalysts, toxic solvents or reagents. Truly green materials must combine these characteristics; consequently, enzymatically synthesized bio-based and/or biodegradable polymers can be characterized as truly green. The present review focuses on the most promising, commercially available aliphatic and alipharomatic polyesters that can be synthesized enzymatically. In particular, the recent developments in the enzymatic polymerization of PLA and PBS and alipharomatic furan-based polyesters (e.g., PBF) are herein analyzed. Based on this analysis, it can be concluded that important steps have been taken toward synthesizing sustainably green polymers. Still, it is necessary to evaluate the applied methods regarding their capability to be used on an industrial scale.

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Section: Type and Characteristics Of The Used Enzyme For Pla Enzymatic Polymerizationmentioning

confidence: 99%

Enzymatic Polymerization as a Green Approach to Synthesizing Bio-Based Polyesters

Gkountela

Vouyiouka

2022

Macromol

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“…PLA has been produced in various continuous-flow reactor setups, including tubular flow and microfluidic devices. 22,[34][35][36][37] Several of these examples employed highly active organo-catalysts that afford low dispersity, controlled polymers with astounding efficiency. 49,50 In particular, we have chosen two common organocatalysts to explore in this investigation, namely 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and 1,5,7triazabicyclo[4.4.0]dec-5-ene (TBD).…”

Section: Pla Synthesis Using Constant Monomer To Initiator Ratiomentioning

confidence: 99%

“…Several lactones have been polymerized in a continuous-flow setup recently, but this has been limited to tubular or microfluidic devices. 22,[34][35][36][37] A range of molar masses (M n ) have been targeted, highlighting the limitations and versatility, covering a broad spectrum of flow rates. Dispersity (Đ) of the resulting amorphous polylactide (PLA) was sensitive to the amplitude of the oscillation, but less dependent on the frequency.…”

Section: Introductionmentioning

confidence: 99%

Fully biobased triblock copolymers generated using an unconventional oscillatory plug flow reactor

Haese

Gemoets²,

Aken³

et al. 2022

Polym. Chem.

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“…As a comparison to traditional batch enzymatic polymerization reaction, the reaction in flow could often obtain high molecular weight and conversion in a short period. For instance, Wissal Adhami et al [ 142 ] had synthesized poly(δ-valerolactone) (PVL), poly (ε-caprolactone) (PCL), and PVL/PCL block copolymer by eROP in flow. As a result, the yield of PCL reached 100% within a period of 4 min at 70 °C, whereas the yield of PVL reached 100% within a period of 10 min at room temperature, and the yield of synthetic copolymer reached 93% after 4 min at 70 °C.…”

Section: The Challenges Of Enzymatic Synthesis Of Polyestermentioning

confidence: 99%

Recent Advances in the Enzymatic Synthesis of Polyester

Wang

Liu²,

Lee

et al. 2022

Polymers

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Polyester is a kind of polymer composed of ester bond-linked polybasic acids and polyol. This type of polymer has a wide range of applications in various industries, such as automotive, furniture, coatings, packaging, and biomedical. The traditional process of synthesizing polyester mainly uses metal catalyst polymerization under high-temperature. This condition may have problems with metal residue and undesired side reactions. As an alternative, enzyme-catalyzed polymerization is evolving rapidly due to the metal-free residue, satisfactory biocompatibility, and mild reaction conditions. This article presented the reaction modes of enzyme-catalyzed ring-opening polymerization and enzyme-catalyzed polycondensation and their combinations, respectively. In addition, the article also summarized how lipase-catalyzed the polymerization of polyester, which includes (i) the distinctive features of lipase, (ⅱ) the lipase-catalyzed polymerization and its mechanism, and (ⅲ) the lipase stability under organic solvent and high-temperature conditions. In addition, this article also focused on the advantages and disadvantages of enzyme-catalyzed polyester synthesis under different solvent systems, including organic solvent systems, solvent-free systems, and green solvent systems. The challenges of enzyme optimization and process equipment innovation for further industrialization of enzyme-catalyzed polyester synthesis were also discussed in this article.

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Polylactones synthesis by enzymatic ring opening polymerization in flow

Cited by 16 publications

References 49 publications

Enzymatic Polymerization as a Green Approach to Synthesizing Bio-Based Polyesters

Enzymatic Polymerization as a Green Approach to Synthesizing Bio-Based Polyesters

Fully biobased triblock copolymers generated using an unconventional oscillatory plug flow reactor

Recent Advances in the Enzymatic Synthesis of Polyester

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