Polylactide Stereocomplex-Based Electrospun Materials Possessing Surface with Antibacterial and Hemostatic Properties

Abstract

Novel fibrous materials of stereocomplex between high-molecular-weight poly(d- or l-)lactide (HMPDLA or HMPLLA) and diblock copolymers consisting of poly(l- or d-)lactide and poly(N,N-dimethylamino-2-ethyl methacrylate) blocks, respectively (PLLA-block-PDMAEMA or PDLA-block-PDMAEMA), were prepared by solution electrospinning. Fibers with mean diameters ranging from 1400 to 1700 nm were obtained. The stereocomplex formation was evidenced by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses. Annealing at 100 degrees C for 8 h resulted in the appearance of crystalline peaks at 2theta values of 12, 21, and 24 degrees for PLA stereocomplex. X-ray photoelectron spectroscopy (XPS) analyses revealed the gradient composition of the fibers with a surface enriched in tertiary amino groups from PDMAEMA blocks. The availability of tertiary amino groups imparts hemostatic and antibacterial properties to the stereocomplex fibrous materials, as indicated by the performed tests on blood cells and on pathogenic microorganisms.

Electrospun poly(L-lactide) membranes containing a single drug or multiple drug system for antimicrobial wound dressings

“…The obtained result is consistent with other data concerning the thermal behavior of PLA based fibrous materials obtained by electrospinning. [17][18][19][20] The preparation of fibrous materials in which PLA is in an amorphous state is attributed to the fast solvent evaporation during the electrospinning which impedes PLA crystallization. The presence of PEG in the PLA/PEG membranes leads to a decrease of the peak corresponding to cold crystallization of PLA ( Figure 2(A)), as well as to the appearance of peaks in the XRD spectrum characteristic of PLA at 2θ =15 o and 22.5 o and of PEG at 2θ =19 o and 23 o .…”

Reactive Extrusion of Stereocomplexed Poly‐L,D‐lactides: Processing, Characterization, and Properties

“…The crystallinity was analyzed by XRD with a D8 Advance Bruker (AXS) instrument. The samples analyzed by XRD were annealed for 8 h at 100 °C in air to enhance crystallinity 16…”

Deposition of PLA/CDHA composite coating via electrospraying

“…No extra diffraction peaks were observed. It is interesting to note the preservation of PLA crystallite after electrospraying, which is different from the absence of PLA crystallite peaks in electrospinning [21]. PLA with high crystallinity can delay the degradation of PLA, which can consequently delay a decrease in pH.…”