Polylactide–hydroxyapatite nanocomposites with highly improved interfacial adhesion via mussel-inspired polydopamine surface modification

Sun, Hongyang; Ai, Miao; Zhu, Siqi; Jia, Xiaolong; Cai, Qing; Yang, Xiaoping

doi:10.1039/c5ra21010k

Cited by 26 publications

(14 citation statements)

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“…coated a layer of polydopamine on the surface of HAP nanorods, and found that the adhesion of polydopamine improved the interfacial binding strength of HAP/PLLA composite film. [ 171 ] Lai et al. modified the surface of HAP particles by coating stearic acid to improve the distribution and phase interface of HAP and polymer.…”

Section: A Type Of Bone Scaffold Materials With Both Mechanical and B...mentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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Section: A Type Of Bone Scaffold Materials With Both Mechanical and B...mentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

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“…These surface modifications improve the dispersion and interfacial adhesion, but their practical applications are limited [ 14 ]. In recent years, the surface modification of nanofillers by mussel-induced dopamine (DA) has been a hot research topic for preparing organic–inorganic composites [ 15 , 16 ]. DA can self-polymerize and turn to polydopamine (PDA) on the surface of nanomaterials, which can enhance the dispersion of the added material by hydrogen bonding or Π-Π interactions with resin macromolecules, achieving a good affinity [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Developing a Novel Enamel Adhesive with Amorphous Calcium Phosphate and Silver Nanoparticles to Prevent Demineralization during Orthodontic Treatment

Jia

Wang

Tong

et al. 2023

JFB

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During fixed orthodontic treatment, white spot lesions are prevalent issues associated with cariogenic bacteria. This study aims to construct an orthodontic adhesive containing nanoparticles of amorphous calcium phosphate-polydopamine-Ag (NPA) fillers to combat white spot lesions. The NPA fillers were prepared and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The biocompatibility of the fillers was evaluated. A colony counting test evaluated the antibacterial property of the fillers against Streptococcus mutans (S. mutans). NPA fillers were mixed with orthodontic adhesive (Transbond XT) at different weight ratios (0, 0.1, 0.2, 0.3, and 0.5 wt.%). The shear bond strength and antibacterial properties were then further investigated. The results showed that NPA was prepared successfully, with good antibacterial properties. The cell survival rate of all groups of fillers was higher than 70%, showing good biocompatibility. Moreover, the shear bond strength of the orthodontic adhesive with 0.2 wt.% NPA fillers was 11.89 ± 1.27 MPa, meeting the minimal clinical bond strength requirements of 7.8 MPa. Furthermore, the orthodontic adhesive resin blocks and the extract displayed good antibacterial properties, with the number of colonies decreasing significantly (p < 0.001). Taken together, we think that an orthodontic adhesive with NPA may have a good application potential for the prevention and treatment of white spot lesions.

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“…Therefore, this material-independent PDA-coating process was very easily, quickly, and efficiently achieved through base-triggered oxidation and polymerization of DA for surface functionalization of various substrates via a single-step process. This PDA ad-layer can be used as a platform for surface modification, including spontaneous deposition of different factors, as well as covalent immobilization of various growth factors and proteins [ 20 , 21 ]. A recent novel strategy to improve the physiological properties of various biomaterials involves the admixing of biological molecular dopamine (DA) and polydopamine (PDA) into the formulation [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

The Physicochemical Properties of Decellularized Extracellular Matrix-Coated 3D Printed Poly(ε-caprolactone) Nerve Conduits for Promoting Schwann Cells Proliferation and Differentiation

Chen

et al. 2018

Materials

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Although autologous nerve grafting remains the gold standard treatment for peripheral nerve injuries, alternative methods such as development of nerve guidance conduits have since emerged and evolved to counter the many disadvantages of nerve grafting. However, the efficacy and viability of current nerve conduits remain unclear in clinical trials. Here, we focused on a novel decellularized extracellular matrix (dECM) and polydopamine (PDA)-coated 3D-printed poly(ε-caprolactone) (PCL)-based conduits, whereby the PDA surface modification acts as an attachment platform for further dECM attachment. We demonstrated that dECM/PDA-coated PCL conduits possessed higher mechanical properties when compared to human or animal nerves. Such modifications were proved to affect cell behaviors. Cellular behaviors and neuronal differentiation of Schwann cells were assessed to determine for the efficacies of the conduits. There were some cell-specific neuronal markers, such as Nestin, neuron-specific class III beta-tubulin (TUJ-1), and microtubule-associated protein 2 (MAP2) analyzed by enzyme-linked immunosorbent assay, and Nestin expressions were found to be 0.65-fold up-regulated, while TUJ1 expressions were 2.3-fold up-regulated and MAP2 expressions were 2.5-fold up-regulated when compared to Ctl. The methodology of PDA coating employed in this study can be used as a simple model to immobilize dECM onto PCL conduits, and the results showed that dECM/PDA-coated PCL conduits can as a practical and clinically viable tool for promoting regenerative outcomes in larger peripheral nerve defects.

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Polylactide–hydroxyapatite nanocomposites with highly improved interfacial adhesion via mussel-inspired polydopamine surface modification

Abstract: The interfacial bonding between inorganic hydroxyapatite and organic polylactide could be significantly improved by introducing polydopamine surface coating on hydroxyapatite.

Cited by 26 publications

References 50 publications

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Developing a Novel Enamel Adhesive with Amorphous Calcium Phosphate and Silver Nanoparticles to Prevent Demineralization during Orthodontic Treatment

The Physicochemical Properties of Decellularized Extracellular Matrix-Coated 3D Printed Poly(ε-caprolactone) Nerve Conduits for Promoting Schwann Cells Proliferation and Differentiation

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