Polylactide-Based Materials: Synthesis and Biomedical Applications

Abstract

Polylactide (PLA) is a biocompatible polyester that can be obtained by polycondensation of lactic acid or the ring-opening polymerization (ROP) of lactide [...]

Advances in Antimicrobial Coatings for Preventing Infections of Head-Related Implantable Medical Devices

“…This attribute significantly elevates the appeal of polymer-based coatings as drug-delivery mechanisms for IMDs and enhancing IMD biocompatibility [48]. Polymers such as PLGA [49], polylactic acid (PLA) [50], chitosan [51], collagen [52], polycaprolactone (PCL) [53], polypyrrole [54], poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) [55], poly(D, l-lactide) (PDLLA) [56], etc., are extensively employed as prospective carriers for antimicrobial agents.…”

Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

“…16 Very recently, a short series of papers edited by Brzeziński and Baśko details the way in which its properties can be varied, with a range of mechanical and chemical means. 17 As discussed in more detail below, it can be made from lactic acid or from lactides, thus explaining how the same polymer has two names.…”

“…Its industrial life‐cycle has been excellently reviewed, 15 and it is very much touted as a material for wider use given that its monomers are biosourced from the fermentation of organic materials 16 . Very recently, a short series of papers edited by Brzeziński and Baśko details the way in which its properties can be varied, with a range of mechanical and chemical means 17 . As discussed in more detail below, it can be made from lactic acid or from lactides, thus explaining how the same polymer has two names.…”

Cooperative effects of Schiff base binuclear zinc complexes on the synthesis of aliphatic and semi-aromatic polyesters

“…However, aliphatic polyesters such as poly(ε-caprolactone) (PCL) and polylactide (PLA) have been attracting considerable attention as renewable and, in some cases, degradable alterna-tives to traditional polymers in biomedical, packaging, and agricultural fields. 6 Currently, the catalytic Ring-Opening Polymerization (ROP) of cyclic esters is one of the most powerful and convenient methods for the preparation of aliphatic polyesters, allowing the synthesis of polymers with desired molecular masses and microstructures. 7 A more recent and less explored method is the sister polymerization method of Ring-Opening COPolymerization (ROCOP) of epoxides and cyclic anhydrides, which offers the opportunity to produce polyesters with a wide range of polymer backbone architectures, including aromatic/ semi-aromatic, thanks to the large availability of structurally different starting monomers.…”

“…However, aliphatic polyesters such as poly(ε-caprolactone) (PCL) and polylactide (PLA) have been attracting considerable attention as renewable and, in some cases, degradable alternatives to traditional polymers in biomedical, packaging, and agricultural fields. 6…”