Polylactic Acid Technology

Henton, David E.; Gruber, Patrick; Lunt, Jim; Randall, Jed

doi:10.1201/9780203508206.ch16

Cited by 224 publications

(304 citation statements)

References 92 publications

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“…Copolymerization modulates not only the phase morphology (amorphous to crystalline phase ratio) and the thermal properties (glass transition temperature, crystallization and melting temperature) but also the degradation rate. Degradation mechanism and kinetics of this series of polymers have been intensively studied [54,55]. Hydrolysis rate is primarily correlated with hydrophobicity of the material that changes depending on the copolymer composition, being lactic acid more hydrophobic than glycolic acid because of the presence of an extra CH 3 group.…”

Section: Biomaterialsmentioning

confidence: 99%

“…3.19 appears to be completely amorphous. P(L)LA is a slow crystallisable polymer compared to many conventional thermoplastic polymers [54,55]. During ES process, polymer chains have little time to organize in a crystal structure before the occurring of fibre solidification and polymer crystallization can be inhibited if crystallization rate is low.…”

Section: Polylactidementioning

confidence: 99%

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Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

Gualandi

2011

Springer Theses

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and some lactide copolymers) and of non-commercial polyesters (i.e. poly-ω-pentadecalactone and some of its copolymers) were explored and discussed.Two techniques were employed to fabricate scaffolds: supercritical carbon dioxide (scCO 2 ) foaming and electrospinning (ES). The former is a powerful technology that enables to produce 3D microporous foams by avoiding the use of solvents that can be toxic to mammalian cells. The scCO 2 process, which is II commonly applied to amorphous polymers, was successfully modified to foam a highly crystalline poly(ω-pentadecalactone-co-ε-caprolactone) copolymer and the effect of process parameters on scaffold morphology and thermo-mechanical properties was investigated.In the course of the present research activity, sub-micrometric fibrous nonwoven meshes were produced using ES technology. Electrospun materials are considered highly promising scaffolds because they resemble the 3D organization of native extra cellular matrix. A careful control of process parameters allowed to fabricate defect-free fibres with diameters ranging from hundreds of nanometers to several microns, having either smooth or porous surface. Moreover, versatility of ES technology enabled to produce electrospun scaffolds from different polyesters as well as "composite" non-woven meshes by concomitantly electrospinning different fibres in terms of both fibre morphology and polymer material. The 3D-architecture of the electrospun scaffolds fabricated in this research was controlled in terms of mutual fibre orientation by properly modifying the instrumental apparatus. This aspect is particularly interesting since the micro/nano-architecture of the scaffold is known to affect cell behaviour.Since last generation scaffolds are expected to induce specific cell response, the present research activity also explored the possibility to produce electrospun scaffolds bioactive towards cells. Bio-functionalized substrates were obtained by loading polymer fibres with growth factors (i.e. biomolecules that elicit specific cell behaviour) and it was demonstrated that, despite the high voltages applied during electrospinning, the growth factor retains its biological activity once

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Section: Biomaterialsmentioning

confidence: 99%

Section: Polylactidementioning

confidence: 99%

Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

Gualandi

2011

Springer Theses

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“…The polymerisation reaction with lactide ring opening proceeds by coordination and substitution mechanism, wherein two lactyl units are bound to the open lactide ring. The ring-opening process is initiated by nucleophilic compounds [5][6][7][8]. Figure 1.…”

Section: Introductionmentioning

confidence: 99%

PLA/PHA-Biodegradable Blends for Pneumothermic Fabrication of Nonwovens

Szuman

Krucińska

Boguń

et al. 2016

Autex Research Journal

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This study presents the results of research concerning fabrication of nonwovens from biodegradable polymer blends using the melt-blown method. The experiments performed within the framework of the research confirmed the possibility of obtaining polymer composites based on polylactide (PLA) with poly(hydroxyalkanoates) (PHA) and another aliphatic-aromatic copolyester. The obtained products were subjected to the analyses of chemical structure using the Fourier Transform Infrared Spectroscopy(FTIR) Attenuated Total Reflectance(ATR) method. The physical and mechanical properties of the fabricated nonwoven layers were also tested, which confirmed a wide spectrum of their applicability, depending on the polymer composition used in production.

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“…Polyester fibers are used in woven and knitted fabrics for apparel and household fabrics and in the construction of functional articles such as car seat belts, nets, ropes and fiber-fill. They are also applied in medical textiles [16][17][18][19][20]. PET exhibits very good mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

A Study of the Effects of Time of Heat Setting and Wet Processes on Shearing (Gf/Cm) Properties of Treated and Untreated Griege Knitted Ingeo™ Poly (Lactic Acid) (Pla) and polyethyleneterepthalate (Pet) Fabric

AN¹

2013

J Textile Sci Eng

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Polylactic Acid Technology

Cited by 224 publications

References 92 publications

Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

PLA/PHA-Biodegradable Blends for Pneumothermic Fabrication of Nonwovens

A Study of the Effects of Time of Heat Setting and Wet Processes on Shearing (Gf/Cm) Properties of Treated and Untreated Griege Knitted Ingeo™ Poly (Lactic Acid) (Pla) and polyethyleneterepthalate (Pet) Fabric

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