Polylactic acid scaffolds obtained by 3D printing and modified by oxygen plasma

Abstract

The purpose of tissue engineering is to repair, replace, and regenerate tissues and organs. For this aim, materials supports, as polylactic acid (PLA) are used. PLA is a thermoplastic polymer that presents biodegradability, biocompatibility and good processability. PLA scaffolds can accurately constructed by 3D printing. Then, the objectives of this work were to modify the hydrophobic surface of PLA scaffolds using oxygen plasma and to study the cell viability and proliferation. The characterization was done by AFM, contact angle, FTIR and studies of proliferation and cell viability. Results showed that the material acquired hydrophilic properties by the presence of oxygen reactive species and by contact angle decrease. It was also observed an increase in the surface roughness. We can conclude that although the surface modifications were effective and the PLA scaffolds were not cytotoxic, there were no improvements in the proliferation process with the studied osteo-1 lineage cells.

Designing and 3d Printed Pla Based Implant Used in Treatment for Unilateral Vocal Cord Paralysis

“…Surface modification and tailoring mechanical properties are simpler than its alternatives [47]. Better biocompatibility can be achieved by surface modifications of PLA [48], [49]. Furthermore, surface coatings with inert materials and making cross-linked PLA with other polymers can increase degradation time and that makes PLA a splendid prosthetics material candidate [50]- [53].…”

3D Filaments Based on Polyhydroxy Butyrate—Micronized Bacterial Cellulose for Tissue Engineering Applications

“…Due to its non-biodegradability and limited cell integration, ABS is not the preferred choice for fabricating tissue engineering scaffolds [ 8 ]. PLA is an example of a biodegradable and bioresorbable thermoplastic biopolymer that has been successfully applied in regenerative medicine and tissue engineering, being widely used for the construction of scaffolds via 3D FDM printing [ 9 , 10 , 11 , 12 ]. In addition, PLA gels can cause irritation via polymer hydrolysis in the surrounding tissue in which they are applied because the pKa of lactic acid is 3.86.…”