Polylactic acid nanoparticles for co-delivery of dinotefuran and avermectin against pear tree pests with improved effective period and enhanced bioactivity

An, Changcheng; Cui, Jianxia; Yu, Qin; Huang, Bingna; Li, Ningjun; Jiang, Jiajun; Shen, Yue; Wang, Chong; Zhan, Shenshan; Zhao, Xiang; Li, Xingye; Sun, Changjiao; Cui, Bo; Gao, Fei; Zeng, Zhanghua; Cui, Haixin; Zhang, Runxiang; Yan, Wang

doi:10.1016/j.ijbiomac.2022.02.182

Cited by 7 publications

(2 citation statements)

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“…Field experiments showed that the DACNPs reduced the frequency of pesticide application, and provided a new strategy for improving the utilization rate of pesticides and reducing environmental pollution. 21 Polylactic acid (PLA) has been approved for drug delivery by the US Food and Drug Administration (FDA). PLA is the polymerized form of lactic acid, which is derived from materials rich in carbohydrates.…”

Section: Introductionmentioning

confidence: 99%

“…constructed a system for the co‐delivery of dinotefuran/avermectin nanoparticles (DACNPs), which exhibited high foliar retention and good spread on leaves. Field experiments showed that the DACNPs reduced the frequency of pesticide application, and provided a new strategy for improving the utilization rate of pesticides and reducing environmental pollution 21 …”

Section: Introductionmentioning

confidence: 99%

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Enhanced fungicidal efficacy and improved interfacial properties with the co‐delivery of prothioconazole and tebuconazole using polylactic acid microspheres

Li,

Sun,

Gao

et al. 2024

Pest Management Science

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BACKGROUNDProthioconazole (PTC) is one of the leading fungicide products worldwide. However, excessive use of PTC facilitates the development of resistance. Pesticide compounding technology plays an important role in reducing pesticide resistance. Microspherization technology for the construction of pesticide dual‐loaded systems has recently provided a new direction for researching novel and efficient pesticide formulations. In this study, prothioconazole‐tebuconazole @ polylactic acid microspheres (PTC‐TBA@PLA MS) were constructed by combining these two technologies.RESULTSThe final PTC‐TBA@PLA MS was selected by an orthogonal method, which were uniformly spherical with smooth surface. The resultant drug loading (DL) and average particle size of PTC‐TBA@PLA MS were 31.34% and 22.3 μm, respectively. A PTC‐TBA@PLA MS suspending agent (SC) with a high suspension rate of 94.3% was prepared according to the suspension rate, dumping ability and stability. Compared with a commercial SC, the PTC‐TBA@PLA MS SC had a larger cumulative release and better interfacial properties. Biological experiments showed that PTC‐TBA@PLA MS SC had an obviously improved bactericidal effect than the commercial SC.CONCLUSIONThe constructed PTC‐TBA@PLA MS system detailed here is expected to reduce the risk of resistance and the frequency of pesticide use while enhancing fungal control.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%