Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans

Shao, Yuting; Wang, Yuxing; Hua, Xin; Li, Yunhui; Wang, Dayong

doi:10.1016/j.chemosphere.2023.139193

Cited by 26 publications

(2 citation statements)

References 77 publications

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“…Caenorhabditis elegans is widely employed in reproductive toxicity studies (Lei et al, 2018; Shao et al, 2023). Its reproduction mainly depends on hermaphrodites which cover 99.5% of the population.…”

Section: Introductionmentioning

confidence: 99%

Reproductive toxicities of dimethyl phthalates on Caenorhabditis elegans with alteration in responses over life stages

Zhang,

Huang,

et al. 2024

Land Degrad Dev

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Phthalate esters (PAEs) raised serious concerns on their health risk due to their toxicities. However, toxicities of low‐molecular‐weight PAEs, for example, dimethyl phthalates (DMPs), remained poorly investigated. In the present study, the reproductive toxicities of dimethyl (o‐)phthalate (DMOP), dimethyl (p‐)phthalate (DMPP), and dimethyl (m‐)phthalate (DMMP) were measured on Caenorhabditis elegans with mechanical exploration. Results showed that DMPP, DMOP, and DMMP commonly inhibited the total reproduction while stimulated lifespan, showing trade‐off effects. In effects on gene expressions, DMPP, DMOP, and DMMP caused different regulations on the expressions of vab‐1, ceh‐18, and gsa‐1 which are involved in oocyte growth, ovulation, and maturation. Meanwhile, they commonly downregulated those of rme‐2 and rcy‐4 that regulate germ cells and gonads and lipid metabolism in oocytes. Moreover, the effects on biochemicals that regulate reproductive processes showed alteration between stimulation and inhibition over life stages. In addition, effects at apical, biochemical, and molecular levels clearly showed the structure influences on the toxicities. Summing up, reproductive toxicities of DMPs depended on the exposure life stages and also the chemical structures.

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Section: Introductionmentioning

confidence: 99%

Reproductive toxicities of dimethyl phthalates on Caenorhabditis elegans with alteration in responses over life stages

Zhang,

Huang,

et al. 2024

Land Degrad Dev

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“…Caenorhabditis elegans exhibits high susceptibility to pollutant toxicity [ 23 , 24 , 25 , 26 ], which makes it suitable for assessing the toxicity of pollutants at PEDs [ 27 , 28 , 29 ]. Meanwhile, C. elegans has a relatively short life cycle [ 30 ], which makes it suitable to evaluate transgenerational toxicity after pollutant exposure [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans

Liu,

Wang,

Bian

et al. 2024

Toxics

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Transgenerational nanoplastic toxicity could be detected in Caenorhabditis elegans after exposure at the parental generation (P0-G); however, the underlying mechanisms remain largely unclear. We aimed to examine the role of germline nuclear hormone receptors (NHRs) in controlling the transgenerational toxicity of polystyrene nanoparticles (PS-NPs) based on gene expression screening and functional analysis. Among germline NHR genes, daf-12, nhr-14, and nhr-47 expressions were increased and nhr-12 expression was decreased by PS-NPs (1 and 10 μg/L). Transgenerational alterations in expressions of these four NHR genes were also induced by PS-NPs (1 and 10 μg/L). RNAi of daf-12, nhr-14, and nhr-47 caused resistance, whereas RNAi of nhr-12 conferred susceptibility to transgenerational PS-NP toxicity. After PS-NP exposure, expressions of ins-3, daf-28, and ins-39 encoding insulin ligands, efn-3 encoding Ephrin ligand, and lin-44 encoding Wnt ligand, as well as expressions of their receptor genes (daf-2, vab-1, and/or mig-1), were dysregulated by the RNAi of daf-12, nhr-14, nhr-47, and nhr-12. Therefore, alteration in certain germline NHRs could mediate the induction of transgenerational nanoplastic toxicity by affecting secreted ligands and their receptors in the offspring of exposed organisms.

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Microplastic environmental behavior and health risk assessment: a review

Lei,

Ma,

Ding

et al. 2024

Environ Chem Lett

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Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans

Cited by 26 publications

References 77 publications

Reproductive toxicities of dimethyl phthalates on Caenorhabditis elegans with alteration in responses over life stages

Reproductive toxicities of dimethyl phthalates on Caenorhabditis elegans with alteration in responses over life stages

Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans

Microplastic environmental behavior and health risk assessment: a review

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