Polyketide Trimming Shapes Dihydroxynaphthalene‐Melanin and Anthraquinone Pigments
Maximilian Schmalhofer,
Anna L. Vagstad,
Qiuqin Zhou
et al.
Abstract:Pigments such as anthraquinones (AQs) and melanins are antioxidants, protectants, or virulence factors. AQs from the entomopathogenic bacterium Photorhabdus laumondii are produced by a modular type II polyketide synthase system. A key enzyme involved in AQ biosynthesis is PlAntI, which catalyzes the hydrolysis of the bicyclic‐intermediate‐loaded acyl carrier protein, polyketide trimming, and assembly of the aromatic AQ scaffold. Here, multiple crystal structures of PlAntI in various conformations and with boun… Show more
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