Polyketide Biosynthesis beyond the Type I, II, and III Polyketide Synthase Paradigms: A Progress Report

Shen, Ben; Cheng, Yi-Qiang; Christenson, Steven D.; Jiang, Hui; Ju, Jianhua; Kwon, Hyung‐Jin; Lim, Si-Kyu; Li, Wen; Nonaka, Kazuhiro; Seo, Jeong-Woo; Smith, Whitney W.; Standage, Scott; Tang, Gong‐Li; Lanen, Steven Van; Zhang, Jian

doi:10.1021/bk-2007-0955.ch011

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…These enzymes catalyze the condensation of activated acyl derivatives (acyl-CoA) on an existing ketide linked to the enzyme via a thioester bond [ 56 ]. Several categories of PKS are described within bacteria, depending on (i) the linear/iterative functioning of the enzyme; and (ii) the way acyl-coA is incorporated (involving or not an Acyl Carrier Protein ACP) [ 57 ]. Hence, to date, three PKS types have been recognized.…”

Section: Antimicrobial Metabolites From Pseudoalteromonamentioning

confidence: 99%

Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance

et al. 2016

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This review is dedicated to the antimicrobial metabolite-producing Pseudoalteromonas strains. The genus Pseudoalteromonas hosts 41 species, among which 16 are antimicrobial metabolite producers. To date, a total of 69 antimicrobial compounds belonging to 18 different families have been documented. They are classified into alkaloids, polyketides, and peptides. Finally as Pseudoalteromonas strains are frequently associated with macroorganisms, we can discuss the ecological significance of antimicrobial Pseudoalteromonas as part of the resident microbiota.

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Section: Antimicrobial Metabolites From Pseudoalteromonamentioning

confidence: 99%

Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance

et al. 2016

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“…1) (Fisch 2013; Shen et al 2007). These non-canonical type I PKSs possess the basic modular organization, but often include unusual arrangements of the functional domains.…”

Section: Type I Pksmentioning

confidence: 99%

Iterative polyketide biosynthesis by modular polyketide synthases in bacteria

Chen

2015

Appl Microbiol Biotechnol

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Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is “non-iterative” in function. It was possible to predict the basic structure of a polyketide product from the module organization of the PKSs, since there generally existed a co-linearity between the number of modules and the number of chain elongations. However, more and more bacterial modular PKSs fail to conform to the “canonical rules”, and a particularly noteworthy group of non-canonical PKSs is the bacterial iterative type I PKSs. This review covers recent examples of iteratively-used modular PKSs in bacteria. These non-canonical PKSs give rise to a large array of natural products with impressive structural diversity. The molecular mechanism behind the iterations is often unclear, presenting a new challenge to the rational engineering of these PKSs with the goal of generating new natural products. Structural elucidation of these synthase complexes and better understanding of potential PKS-PKS interactions as well as PKS-substrate recognition may provide new prospects and inspirations for the discovery and engineering of new bioactive polyketides.

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“…PKS can be subdivided into modular and iterative synthases. The former usually leads to larger structures of a higher degree of complexity, while the latter results in smaller molecules . Both fatty acid and PKS‐pathways are being explored for the production of hydrocarbons by decarboxylation.…”

Section: Next Generation Technologiesmentioning

confidence: 99%

Fueling the future with biomass: Processes and pathways for a sustainable supply of hydrocarbon fuels and biogas

Junne

Kabisch

2016

Engineering in Life Sciences

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Global economic growth, wealth and security rely upon the availability of cheap, mostly fossil‐derived energy and chemical compounds. The replacement by sustainable resources is widely discussed. However, the current state of biotechnological processes usually restricts them to be used as a true alternative in terms of economic feasibility and even sustainability. Among the rare examples of bioprocesses applied for the energetic use of biomass are biogas and bioethanol production. Usually, these processes lack in efficiency and they cannot be operated without the support of legislation. Although they represent a first step towards a greater share of bio‐based processes for energy provision, there is no doubt that tremendous improvements in strain and process development, feedstock and process flexibility as well as in the integration of these processes into broader supply and production networks, in this review called smart bioproduction grids, are required to make them economically attractive, robust enough, and wider acceptance by society. All this requires an interdisciplinary approach, which includes the use of residues in closed carbon cycles and issues concerning the process safety. This short review aims to depict some of the promising strategies to achieve an improved process performance as a basis for future application.

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Polyketide Biosynthesis beyond the Type I, II, and III Polyketide Synthase Paradigms: A Progress Report

Cited by 11 publications

References 11 publications

Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance

Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance

Iterative polyketide biosynthesis by modular polyketide synthases in bacteria

Fueling the future with biomass: Processes and pathways for a sustainable supply of hydrocarbon fuels and biogas

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