Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.

Abstract

Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp. M16 led to the isolation of seven new polyketide-and terpenoid-derived metabolites (1, 2, 4−8), along with known polyketides (3, 9−13). Structures of compounds 1, 2, and 4−8 were established by analysis of spectroscopic data. Absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by the comparison of experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum.

Recent Updates on the Antimicrobial Compounds from Marine‐Derived Penicillium fungi

“…Terpenoids and polyketides accounted for the largest proportion in various compounds. [82,83,84,85] In addition to terpenoids, polyketides and alkaloids, there are some other structural compounds with small proportions from marine Penicillium spp. The antimicrobial activities of other compounds from marine Penicillium spp.…”