Polyketide and Prenylxanthone Derivatives from the Endophytic Fungus <i>Aspergillus</i> sp. TJ23

Qiao, Yuben; Tu, Kun; Feng, Wenya; Liu, Junjun; Xu, Qianqian; Li, Tao; Zhu, Hucheng; Chen, Chunmei; Wang, Jianping; Xue, Yongbo; Zhang, Yonghui

doi:10.1002/cbdv.201800395

Cited by 11 publications

(11 citation statements)

References 21 publications

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“…Ergosterol (33) showed potent inhibitory activities against the cancer cell lines HepG2, B16, LLC, MDA-MB-231 and 4T1 with IC 50 values of (5.31 AE 0.03), (6.52 AE 0.02), (7.31 AE 0.02), (7.36 AE 0.03) and (12.3 AE 0.04) mM respectively. 59 Ferulic acid (172) and r-hydroxyphenyl acetic acid (173) are phenolic acids isolated from the fermented culture of the endophytic fungus Aspergillus sp. associated with the leaves of the plant Moringa oleifera (Fig.…”

Section: Aspergillus Versicolormentioning

confidence: 99%

Natural product diversity from the endophytic fungi of the genusAspergillus

et al. 2020

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Section: Aspergillus Versicolormentioning

confidence: 99%

Natural product diversity from the endophytic fungi of the genusAspergillus

et al. 2020

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“…Fungal strain Aspergillus sp. TJ23 was isolated and identified as a producer of asperetide, a polyketide and asperanthone, a derivative of prenylxanthone (Qiao et al 2018 ).…”

Section: Endophytes: Reservoir Of Bioactive Compoundsmentioning

confidence: 99%

Plant associated fungal endophytes as a source of natural bioactive compounds

et al. 2021

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Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds. Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds. Numerous bioactive compounds with antioxidant, antimicrobial, anticancer, and immunomodulatory properties are known to be derived from fungal endophytes. Bioinformatics tools along with the latest techniques such as metabolomics, next-generation sequencing, and metagenomics multilocus sequence typing can potentially fill the gaps in fungal endophyte research. The current review article focuses on bioactive compounds derived from plantassociated fungal endophytes and their pharmacological importance. We conclude with the challenges and opportunities in the research area of fungal endophytes.

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“…(2018a) Xanthones Asperanthone (25) HepG2 35.5 ± 0.06 μM Aspergillus sp. TJ23 Hypericum perforatum L (T) China Qiao et al. (2018) Xanthoquinodin B9 (26) KB 7.04 μM Chaetomium globosum 7s-1 Rhapis cochinchinensis (Lour.)…”

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

Endophytic fungi: A treasure trove of novel anticancer compounds

Prajapati

Goswami

Rawal

2021

Current Research in Pharmacology and Drug Discovery

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Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Henceforth, there is undeniably an inflated necessity for safe, promising, and less harmful new anticancer drugs. Natural compounds from various sources like plants, animals, and microorganisms have occupied a center stage in drug discovery due to their tremendous chemical diversity and potential as therapeutic agents. Endophytic microbes are symbiotically associated with plants and have been proven to produce novel or analogues of host bioactive metabolites exhibiting a variety of biological activities including anticancer activity. This review emphasizes on structurally diverse unprecedented anticancer natural compounds that have been reported exclusively from endophytic fungi from 2016 to 2020. It covers chemical nature of metabolites, its fungal source associated with terrestrial, as well as marine plants and anticancer activity based on their cytotoxicity profile against various cancer cell lines. Many of these fungal metabolites with promising anticancer activity can be used as lead molecules for in silico experiments and deserve special attention from scientists for further in vitro and clinical research.

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Polyketide and Prenylxanthone Derivatives from the Endophytic Fungus Aspergillus sp. TJ23

Cited by 11 publications

References 21 publications

Natural product diversity from the endophytic fungi of the genusAspergillus

Natural product diversity from the endophytic fungi of the genusAspergillus

Plant associated fungal endophytes as a source of natural bioactive compounds

Endophytic fungi: A treasure trove of novel anticancer compounds

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