Polyisoprene matrix for progesterone release: In vitro and in vivo studies

Heredia, Valeria; Bianco, Ismael D.; Tríbulo, H.; Tribulo, R.; Seoane, M. Ferro; Faudone, Sonia Nerina; Cuffini, Silvia Lucía; Demichelis, N.A.; Schalliol, H.; Beltramo, Dante M.

doi:10.1016/j.ijpharm.2009.08.015

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…Two types of intravaginal devices loaded with progesterone for estrous synchronization in cattle were studied by Heredia et al . . To obtain them, room temperature vulcanizing PDMS or latex sheets were impregnated with a solution of the drug in organic solvents, after which the remaining solvent was evaporated using an air steam.…”

Section: Polymers For Veterinary Applicationsmentioning

confidence: 99%

Challenges and opportunities in polymer technology applied to veterinary medicine

Bermúdez

Cid

Ramírez-Rigo

et al. 2013

Vet Pharm & Therapeutics

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An important frontier in the administration of therapeutic drugs to veterinary species is the use of different polymers as drug delivery platforms. The usefulness of polymers as platforms for the administration of pharmaceutical and agricultural agents has been clearly recognized in the recent decades. The chemical versatility of polymers and the wide range of developed controlled-release strategies enhance the possibilities for the formulation of active molecules. In particular, the veterinary area offers opportunities for the development of novel controlled-release drug delivery technologies adapted to livestock or companion animal health needs. In some cases, it also allows to improve profitability in meat production or to meet the safety criteria related to drug residues. A number of factors affect the selection of polymers and subsequent properties of the controlled-release drug delivery system. However, their selection also dictates the release kinetics of the drug from the delivery system. Such choices are therefore crucial as they affect the success and potential of the delivery system for achieving the therapeutic goals of the veterinarian. It is the intention of this review to give an overview of the most relevant polymers, which are used or have been tested as drug delivery release rate modifiers in the veterinary field. The article highlights some recent developments focusing on their advantages and applications and analyzes the future direction of the scientific and technological advancements in this area.

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Section: Polymers For Veterinary Applicationsmentioning

confidence: 99%

Challenges and opportunities in polymer technology applied to veterinary medicine

Bermúdez

Cid

Ramírez-Rigo

et al. 2013

Vet Pharm & Therapeutics

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“…solid-phase NMR in the case of prednisolone in controlled porosity osmotic pump pellets in the presence of excipients [64]. The polymorphic status of progesterone in a polyisoprene matrix for intravaginal drug delivery was measured by FT-IR and XRPD [65].…”

Section: Solid Phase Characterizationmentioning

confidence: 99%

Advances in the analysis of steroid hormone drugs in pharmaceuticals and environmental samples (2004–2010)

Gǒrög

2011

Journal of Pharmaceutical and Biomedical Analysis

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“…progesterone crystallized in its form 1 on polydimethylsiloxane; nevertheless, on polyisoprene (PI) it was obtained as a mixture of both polymorphs. Using PI, the presence of form 2 (metastable) increased the dissolution rate of progesterone in the device . However, there is no evidence of a complete polymorphic screening of progesterone using PIHn method.…”

Section: Introductionmentioning

confidence: 99%

“…In a recent study the potential use of polyisoprene (PI) as a matrix for a new and more efficient intravaginal drug delivery system of progesterone to be use in veterinarian was evaluated . According to Heredia et al.…”

Section: Introductionmentioning

confidence: 99%

Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (PIHn) method

Araya-Sibaja

Soldi

Campos

et al. 2015

Crystal Research and Technology

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The selective crystallization of progesterone polymorphs prepared by Polymer-Induced Heteronucleation (PIHn) method was investigated. Polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), dextran, gelatin, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as heteronucleants. Crystallizations were conducted from 0.5, 10 and 40 mg mL −1 solutions in chloroform at room temperature by solvent evaporation. The samples were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy and scanning electron microscopy. Form 2 was obtained from 0.5 mg mL −1 solution in almost all polymers. A mixture of both polymorphs crystallized from the three concentrations on gelatine; from 10 and 40mg mL −1 on PVA and HPMC and, from 10 mg mL −1 solutions on NBR. Form 2 crystallized on HPMC was stable for three months under ambient stress conditions (40ºC and 75% RH). These results are good evidence that the tailoring of new formulations and devices with progesterone the metastable and more soluble form 2 is possible.

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Polyisoprene matrix for progesterone release: In vitro and in vivo studies

Cited by 8 publications

References 19 publications

Challenges and opportunities in polymer technology applied to veterinary medicine

Challenges and opportunities in polymer technology applied to veterinary medicine

Advances in the analysis of steroid hormone drugs in pharmaceuticals and environmental samples (2004–2010)

Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (PIHn) method

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