Polyisobutylene‐based biomaterials

Abstract

This article highlights the biomaterial-related research of the Macromolecular Engineering Research Centre (MERC). The MERC group concentrated on polyisobutylene (PIB)-based biomaterials. In this article, first the unique properties of PIB are discussed, followed by a review of PIB-based potential biomaterials. MERC's systematic research program aimed to develop novel PIB-based biomaterials is then highlighted, including surface modification and biocompatibility studies.

Synthesis of Poly(methyl methacrylate)-poly(poly(ethylene glycol) methacrylate)-polyisobutylene ABCBA Pentablock Copolymers by Combining Quasiliving Carbocationic and Atom Transfer Radical Polymerizations and Characterization Thereof

“…properties, it is of special importance that both polymers possess non-immunogeneity and bioand blood compatibility (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). For all these reasons, it is expected that the integration of these two types of polymer segments into one macromolecule may lead to a variety of new application possibilities.…”

Phase-Segregated Dendrigraft Copolymer Architectures

“…Unfortunately this calculation method can lead to an underestimated branching functionality, because chain growth is faster for the linear polymer contaminant than for the graft polymer [35,36]. The one-pot synthesis of arborescent polyisobutylene structures by cationic polymerization in the presence of inimers (monomers containing a latent initiating site within their structure) has received much attention by the group of Puskas [37]. This technique, initially developed for the preparation of arborescent isobutylene homopolymers, was subsequently extended to the preparation of copolymers with polystyrene or poly(p-methylstyrene) segments as shown in Scheme 5.…”

Controlled synthesis of amphiphilic block copolymers based on poly(isobutylene) macromonomers

“…[4][5][6][7][8] These materials have been demonstrated to be effective for a number of applications, such as polymeric surfactants and dispersants, sealants, coatings, adhesives, and drug delivery vehicles. [9][10][11][12][13][14][15] Preparation of PIB graft copolymers and APCN rely on the synthesis of well-defined mono or multi functionalized PIB macromonomers. This has been previously achieved by hydroboration and oxidation of allyl terminated PIB to hydroxyl terminated PIB, which can be subsequently esterified with (meth)acryloyl chloride to PIB (meth)acrylate.…”