Polyisobutylcyanoacrylate nanoparticles as sustained release system for calcitonin

Tasset, Chantal; Barette, N.; Thysman, Sophie; Ketelslegers, Jean‐Marie; Lemoine, D.; Préat, Véronique

doi:10.1016/0168-3659(94)00060-8

Cited by 34 publications

(14 citation statements)

References 16 publications

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“…However, administration of peptides and proteins through oral route remains a challenging task due to poor bioavailability (1). Incorporation of protein and peptide into polymeric nanoparticles and microparticles has gained a lot of interest in the last two decades to improve their oral bioavailability and stability (2)(3)(4)(5). Chitosan is one of the polymers which have gained a lot of attention in nanoparticulate drug delivery system of protein and peptide (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Serratiopeptidase Loaded Chitosan Nanoparticles by Polyelectrolyte Complexation: In Vitro and In Vivo Evaluation

2014

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Abstract. The aim of the present study was to formulate serratiopeptidase (SER)-loaded chitosan (CS) nanoparticles for oral delivery. SER is a proteolytic enzyme which is very sensitive to change in temperature and pH. SER-loaded CS nanoparticles were fabricated by ionic gelation method using tripolyphosphate (TPP). Nanoparticles were characterized for its particle size, morphology, entrapment efficiency, loading efficiency, percent recovery, and in vitro dissolution study. SER-CS nanoparticles had a particle size in the range of 400-600 nm with polydispersity index below 0.5. SER association was up to 80 ±4.2%. SER loading and CS/TPP mass ratio were the primary parameters having direct influence on SER-CS nanoparticles. SER-CS nanoparticles were freeze dried using trehalose (20%) as a cryoprotectant. In vitro dissolution showed initial burst followed by sustained release up to 24 h. In vivo antiinflammatory activity was carried out in rat paw edema model. In vivo anti-inflammatory activity in rat paw edema showed prolonged anti-inflammatory effect up to 32 h relative to plain SER.

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Section: Introductionmentioning

confidence: 99%

Serratiopeptidase Loaded Chitosan Nanoparticles by Polyelectrolyte Complexation: In Vitro and In Vivo Evaluation

2014

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“…Another polymer that was used in the production of sCT microcapsules was biodegradable poly(DL-lactic acid) [ 28 ]. Poly(lactide-co-glicolide) (PLGA) microspheres [ 29 , 30 ], polyisobutylcyanoacrylate nanoparticles [ 31 ], and poly(ethylene glycol)-terephthalate (PEGT)/poly(butylene terephthalate) (PBT) [ 32 ] are also among the other reported biodegradable polymers used for controlled and sustained delivery of sCT. Absorption enhancers such as hydroxypropyl- and dimethyl-beta-cyclodextrins [ 33 ], the bile salts, chitosan, and loryl carnitin were evaluated for enhancing absorption of sCT from nasal route in rats [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Prolonged Hypocalcemic Effect by Pulmonary Delivery of Calcitonin Loaded Poly(Methyl Vinyl Ether Maleic Acid) Bioadhesive Nanoparticles

Varshosaz

Minaiyan

Forghanian

2014

BioMed Research International

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The purpose of the present study was to design a pulmonary controlled release system of salmon calcitonin (sCT). Therefore, poly(methyl vinyl ether maleic acid) [P(MVEMA)] nanoparticles were prepared by ionic cross-linking method using Fe2+ and Zn2+ ions. Physicochemical properties of nanoparticles were studied in vitro. The stability of sCT in the optimized nanoparticles was studied by electrophoretic gel method. Plasma calcium levels until 48 h were determined in rats as pulmonary-free sCT solution or nanoparticles (25 μg·kg−1), iv solution of sCT (5 μg·kg−1), and pulmonary blank nanoparticles. The drug remained stable during fabrication and tests on nanoparticles. The optimized nanoparticles showed proper physicochemical properties. Normalized reduction of plasma calcium levels was at least 2.76 times higher in pulmonary sCT nanoparticles compared to free solution. The duration of hypocalcemic effect of pulmonary sCT nanoparticles was 24 h, while it was just 1 h for the iv solution. There was not any significant difference between normalized blood calcium levels reduction in pulmonary drug solution and iv injection. Pharmacological activity of nanoparticles after pulmonary delivery was 65% of the iv route. Pulmonary delivery of P(MVEMA) nanoparticles of sCT enhanced and prolonged the hypocalcemic effect of the drug significantly.

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“…There are many cases where environmental temperature or pH fluctuations can occur. Potential values of such nanocapsules are given for cosmetic and pharmaceutical applications . The protection of the desired drug in defined environments, especially in the body and the selective release of the encapsulated material, caused by the pH‐change is fundamental and highly beneficial for the human organism.…”

Section: Introductionmentioning

confidence: 99%

pH Stability of Poly(urethane/urea) Capsules Synthesized from Different Hydrophilic Monomers via Interfacial Polyaddition in the Inverse Miniemulsion Process

Baier

Friedemann

Leuschner

et al. 2013

Macromolecular Symposia

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Poly(urethane/urea) capsules with different hydrophilic monomers and toluene-2,4-diisocyanate were prepared using a polyaddition reaction in inverse miniemulsion. The morphology and the size distribution of the prepared capsules were studied via transmission electron microscopy (TEM), scanning electron microscopy (SEM), and dynamic light scattering (DLS). Furthermore, the capsules were transferred into an aqueous surfactant containing solution and exposed to different pH values (2.5, 7 and 9). The changes in the capsule's shell stability were studied by measuring the amount of a released dye, which had previously been encapsulated, using fluorescence spectroscopy. The specific surface area of nanocapsules was calculated from nitrogen sorption measurements (Brunauer-Emmett-Teller (BET)).

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Polyisobutylcyanoacrylate nanoparticles as sustained release system for calcitonin

Cited by 34 publications

References 16 publications

Serratiopeptidase Loaded Chitosan Nanoparticles by Polyelectrolyte Complexation: In Vitro and In Vivo Evaluation

Serratiopeptidase Loaded Chitosan Nanoparticles by Polyelectrolyte Complexation: In Vitro and In Vivo Evaluation

Prolonged Hypocalcemic Effect by Pulmonary Delivery of Calcitonin Loaded Poly(Methyl Vinyl Ether Maleic Acid) Bioadhesive Nanoparticles

pH Stability of Poly(urethane/urea) Capsules Synthesized from Different Hydrophilic Monomers via Interfacial Polyaddition in the Inverse Miniemulsion Process

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