Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property

Jang, Woo Dong; Nakagishi, Yoshinori; Nishiyama, Nobuhiro; Kawauchi, Satoko; Morimoto, Yuji; Kikuchi, Makoto; Kataoka, Kazunori

doi:10.1016/j.jconrel.2006.03.009

Cited by 129 publications

(74 citation statements)

References 21 publications

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“…Although that part of nanomedicine is highlighted as one of the most promising field, it faces with two crucial problems. Despite complex design of nano-carriers, such as synthesis of polyion complex micelles via electrostatic interactions between phthalocyanine complexes and various block copolymers [11], uncontrolled nanodrug aggregation and inefficient cell penetration is always present in most nanodrug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Nanothermodynamics Mediates Drug Delivery

Stefi

Sarantopoulou

Kollia

et al. 2014

Advances in Experimental Medicine and Biology

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The efficiency of penetration of nanodrugs through cell membranes imposes further complexity due to nanothermodynamic and entropic potentials at interfaces. Action of nanodrugs is effective after cell membrane penetration. Contrary to diffusion of water diluted common molecular drugs, nanosize imposes an increasing transport complexity at boundaries and interfaces (e.g., cell membrane). Indeed, tiny dimensional systems brought the concept of "nanothermodynamic potential," which is proportional to the number of nanoentities in a macroscopic system, from either the presence of surface and edge effects at the boundaries of nanoentities or the restriction of the translational and rotational degrees of freedom of molecules within them. The core element of nanothermodynamic theory is based on the assumption that the contribution of a nanosize ensemble to the free energy of a macroscopic system has its origin at the excess interaction energy between the nanostructured entities. As the size of a system is increasing, the contribution of the nanothermodynamic potential to the free energy of the system becomes negligible. Furthermore, concentration gradients at boundaries, morphological distribution of nanoentities, and restriction of the translational motion from trapping sites are the source of strong entropic potentials at the interfaces. It is evident therefore that nanothermodynamic and entropic potentials either prevent or allow enhanced concentration very close to interfaces and thus strongly modulate nanoparticle penetration within the intracellular region. In this work, it is shown that nano-sized polynuclear iron (III)-hydroxide in sucrose nanoparticles have a nonuniform concentration around the cell membrane of macrophages in vivo, compared to uniform concentration at hydrophobic prototype surfaces. The difference is attributed to the presence of entropic and nanothermodynamic potentials at interfaces.

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Section: Introductionmentioning

confidence: 99%

Nanothermodynamics Mediates Drug Delivery

Stefi

Sarantopoulou

Kollia

et al. 2014

Advances in Experimental Medicine and Biology

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“…In use of PIC micelles, nucleic acid drugs 2,10,11 and some proteins 12 have been successfully incorporated in the core of micelles. However, only a few kinds of polymers have been used as cationic segment, including poly(L-lysine), 13 poly(dimethylaminoethyl methacrylate), 10 and poly(ethylenimine) 11 and so on. There are still some problems with these polymers, for instance, their poor biodegradability…”

Section: Introductionmentioning

confidence: 99%

Novel polyion complex micelles for liver‐targeted delivery of diammonium glycyrrhizinate: In vitro and in vivo characterization

Yang

Zhuo

et al. 2008

J Biomedical Materials Res

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Polyion complex micelles (PIC micelles) based on methoxy poly(ethylene glycol)-grafted-chitosan (mPEG-g-Chitosan) and lactose-conjugated PEG-grafted-chitosan (Lac-PEG-g-Chitosan) were designed as carriers for anionic drugs. Diammonium glycyrrhizinate (DG)-loaded conventional PIC micelles (mPIC micelles) and lactose-modified PIC micelles (Lac-PIC micelles) were prepared successfully with encapsulation efficiency of 97.4% and 96.7%, respectively. These micelles were uniform spherical particles with a mean size of 21.6 and 26.4 nm by transmission electron microscopy, respectively. No significant size change of these micelles in three months indicated their good physical stability. The in vitro drug release behavior of mPIC micelles in different media as well as the changes of size and zeta potential demonstrated that the drug was released mainly through swelling and diffusion induced by ion exchange. The pharmacokinetic experiments showed that the area under the curve of DG plasma concentration-time profile in rats for mPIC micelles and Lac-PIC micelles were 1.2 times and 0.4 times higher than that for DG injection, respectively. The liver targeting ability of both mPIC micelles and Lac-PIC micelles was evaluated in rats, revealing that Lac-PIC micelles could deliver more DG to liver than mPIC micelles. Therefore, the Lac-PIC micelles prepared in this study were promising liver-targeted nanocarriers for DG.

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“…28,[44][45][46] DPc-loaded micelles, approximately 50 nm in diameter, were prepared from DPc and PEG-b-PLL in a manner similar to the DP-loaded micelles. 47 Unlike DP, loading DPc into micelles shifted the absorption maximum from 685 to 630 nm, indicating possible interactions between the phthalocyanine units in the micellar core. The relatively small dendritic wedges in DPc may not be sufficient to prevent such interactions.…”

Section: Formation Of Dpc-loaded Pic Micellesmentioning

confidence: 99%

“…Consequently, DPc-loaded micelles consume less oxygen than DPc alone. 47 DPc-loaded micelles, however, significantly enhanced photocytotoxicity, which relies on the photoirradiation time. DPc-loaded micelles exhibited approximately 100 times higher photocytotoxicity than free DPc upon 60 min of photoirradiation.…”

Section: Formation Of Dpc-loaded Pic Micellesmentioning

confidence: 99%

Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications

Jeong

Yoon

Jang

2012

Polym J

Self Cite

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Dendrimers have attracted great interest for the design of functional materials. Because the core porphyrin unit in dendrimer porphyrin (DP) is surrounded by large poly(benzyl ether) dendritic wedges with ionic peripheries, the resulting electrostatic interaction with oppositely charged polymeric materials has been used to create various functional nano-devices. In this paper, we briefly review DP-based self-assembled biomedical nano-devices, including DP-loaded polyion complex micelles, the ternary complex systems used for gene delivery, polymer-metal complex micelles, the hollow nanocapsules used for combination cancer therapy, and the DP-immobilized surfaces used for diagnostic tools.

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Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property

Cited by 129 publications

References 21 publications

Nanothermodynamics Mediates Drug Delivery

Nanothermodynamics Mediates Drug Delivery

Novel polyion complex micelles for liver‐targeted delivery of diammonium glycyrrhizinate: In vitro and in vivo characterization

Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications

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