Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer

Zhang, Guo Dong; Harada, Atsushi; Nishiyama, Nobuhiro; Jiang, Donglin; Koyama, Hiroyuki; Aida, Takuzo; Kataoka, Kazunori

doi:10.1016/j.jconrel.2003.05.002

Cited by 160 publications

(94 citation statements)

References 29 publications

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“…PS can be modified by encapsulated them in delivery agents such as liposomes [54], micelles [55,56,57,58], ceramic based nanoparticles [59], gold nanoparticles [60,61], and polymer nanoparticles [62]. Liposomes, for example, are able to encapsulate hydrophobic as well as hydrophilic drugs.…”

Section: 'Nano' Strategies For Photosensitizermentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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Section: 'Nano' Strategies For Photosensitizermentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

View full text Add to dashboard Cite

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“…In addition, large dendritic wedges effectively prevent aggregation. [31][32][33][34] The high solubility of DP and DPc permits their use in PDT, a promising technology for less invasive cancer treatments. PDT involves the systemic administration of photosensitizers (PS) followed by the irradiation of the target tissue with laser light.…”

Section: Structure and Characteristics Of Dendrimer Porphyrin And Phtmentioning

confidence: 99%

“…When DP was used as a PS, it exhibited 10-100 times higher photocytotoxicity than protoporphyrin IX, a conventional PS, for treating Lewis lung carcinoma (LLC). 33 Moreover, the ionic surfaces of DP and DPc have been used to form polyion complex (PIC) micelles through electrostatic interactions. In vitro and in vivo experiments have demonstrated that PIC micelles are successful formulations for use in PDT.…”

Section: Structure and Characteristics Of Dendrimer Porphyrin And Phtmentioning

confidence: 99%

Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications

Jeong

Yoon

Jang

2012

Polym J

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Dendrimers have attracted great interest for the design of functional materials. Because the core porphyrin unit in dendrimer porphyrin (DP) is surrounded by large poly(benzyl ether) dendritic wedges with ionic peripheries, the resulting electrostatic interaction with oppositely charged polymeric materials has been used to create various functional nano-devices. In this paper, we briefly review DP-based self-assembled biomedical nano-devices, including DP-loaded polyion complex micelles, the ternary complex systems used for gene delivery, polymer-metal complex micelles, the hollow nanocapsules used for combination cancer therapy, and the DP-immobilized surfaces used for diagnostic tools.

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“…They are formed as a result of the reaction of double hydrophilic block copolymers containing ionic and nonionic blocks with macromolecules of opposite charge including oligonucleotides, plasmid DNA and proteins (Kabanov et al 1995;Harada and Kataoka 1999a, b;Nguyen et al 2000;Zhang et al 2003;Jaturanpinyo et al 2004), or surfactants of opposite charge (Bronich et al 1997(Bronich et al , 1998(Bronich et al , 1999Solomatin et al 2003Solomatin et al , 2004. For example, block ionomer complexes were prepared by reacting trypsin or lysozyme (that are positively charged under physiological conditions) with an anionic block copolymer, PEG-poly(α,β-aspartic acid) (Harada and Kataoka 1999b;Jaturanpinyo et al 2004).…”

Section: Nanomaterials For Drug Delivery Across the Blood-brain Barriermentioning

confidence: 99%

Novel Nanomaterials for Clinical Neuroscience

Gilmore

Xiang

Quan

et al. 2008

J Neuroimmune Pharmacol

205

123

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Neurodegenerative disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population ages. The field of nanomedicine is rapidly expanding and promises revolutionary advances to the diagnosis and treatment of devastating human diseases. This paper provides an overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders. Examples include liposomes, nanoparticles, polymeric micelles, block ionomer complexes, nanogels, and dendrimers that have been tested clinically or in experimental models for delivery of drugs, genes, and imaging agents. More recently discovered nanotubes and nanofibers are evaluated as promising scaffolds for neuroregeneration. Novel experimental neuroprotective strategies also include nanomaterials, such as fullerenes, which have antioxidant properties to eliminate reactive oxygen species in the brain to mitigate oxidative stress. Novel technologies to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain. Furthermore, by combining such nanomaterials with cell-based delivery strategies, the outcomes of neurodegenerative disorders can be greatly improved.

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Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer

Cited by 160 publications

References 29 publications

Nanodrug applications in photodynamic therapy

Nanodrug applications in photodynamic therapy

Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications

Novel Nanomaterials for Clinical Neuroscience

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