Polyimide Electrode-Based Electrical Stimulation Impedes Early Stage Muscle Graft Regeneration

Srinivasan, Shriya; Vyas, Keval; McAvoy, Malia; Calvaresi, Peter; Khan, Omar F.; Langer, Robert; Anderson, Daniel G.; Herr, Hugh M.

doi:10.3389/fneur.2019.00252

Cited by 8 publications

(7 citation statements)

References 51 publications

(78 reference statements)

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“…The individual also exhibited reflexive prosthesis motions indicating a higher level of embodiment. In order to produce this antagonist mechanical linkage for individuals who have already received a ‘traditional’ amputation surgery, a regenerative neural interface has been proposed to implement AMI through the use of targeted muscle reinnervation (TMR) and muscle grafts [ 50 , 51 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Myoelectric control of robotic lower limb prostheses: a review of electromyography interfaces, control paradigms, challenges and future directions

et al. 2021

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Objective. Advanced robotic lower limb prostheses are mainly controlled autonomously. Although the existing control can assist cyclic movements during locomotion of amputee users, the function of these modern devices is still limited due to the lack of neuromuscular control (i.e. control based on human efferent neural signals from the central nervous system to peripheral muscles for movement production). Neuromuscular control signals can be recorded from muscles, called electromyographic (EMG) or myoelectric signals. In fact, using EMG signals for robotic lower limb prostheses control has been an emerging research topic in the field for the past decade to address novel prosthesis functionality and adaptability to different environments and task contexts. The objective of this paper is to review robotic lower limb Prosthesis control via EMG signals recorded from residual muscles in individuals with lower limb amputations. Approach. We performed a literature review on surgical techniques for enhanced EMG interfaces, EMG sensors, decoding algorithms, and control paradigms for robotic lower limb prostheses. Main results. This review highlights the promise of EMG control for enabling new functionalities in robotic lower limb prostheses, as well as the existing challenges, knowledge gaps, and opportunities on this research topic from human motor control and clinical practice perspectives. Significance. This review may guide the future collaborations among researchers in neuromechanics, neural engineering, assistive technologies, and amputee clinics in order to build and translate true bionic lower limbs to individuals with lower limb amputations for improved motor function.

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Section: Literature Reviewmentioning

confidence: 99%

Myoelectric control of robotic lower limb prostheses: a review of electromyography interfaces, control paradigms, challenges and future directions

et al. 2021

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“…For example, designers should be aware that electrode interfaces may impede blood flow and nutrient diffusion that can be necessary for survival of the grafts at the early stages of muscle regeneration. 107 As discussed in the Wireless Transmission section, one of the major challenges of implantable recording interfaces in general is achieving effective data and power transmission. Continued research on Wireless Sensor Networks-networks of sensors spatially distributed throughout the body which communicate wirelessly with one central device-can allow for easier communication even with a large number of electrodes.…”

Section: Current Challenges and Limitationsmentioning

confidence: 99%

“…To further complicate matters, many muscle interfaces are expected to be suitable for not only intact muscle, but regenerating muscle grafts. For example, designers should be aware that electrode interfaces may impede blood flow and nutrient diffusion that can be necessary for survival of the grafts at the early stages of muscle regeneration 107 …”

Section: Current Challenges and Limitationsmentioning

confidence: 99%

Neuromuscular implants: Interfacing with skeletal muscle for improved clinical translation of prosthetic limbs

Quinn,

Tian,

Budde

et al. 2023

Muscle and Nerve

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After an amputation, advanced prosthetic limbs can be used to interface with the nervous system and restore motor function. Despite numerous breakthroughs in the field, many of the recent research advancements have not been widely integrated into clinical practice. This review highlights recent innovations in neuromuscular implants—specifically those that interface with skeletal muscle—which could improve the clinical translation of prosthetic technologies. Skeletal muscle provides a physiologic gateway to harness and amplify signals from the nervous system. Recent surgical advancements in muscle reinnervation surgeries leverage the “bio‐amplification” capabilities of muscle, enabling more intuitive control over a greater number of degrees of freedom in prosthetic limbs than previously achieved. We anticipate that state‐of‐the‐art implantable neuromuscular interfaces that integrate well with skeletal muscle and novel surgical interventions will provide a long‐term solution for controlling advanced prostheses. Flexible electrodes are expected to play a crucial role in reducing foreign body responses and improving the longevity of the interface. Additionally, innovations in device miniaturization and ongoing exploration of shape memory polymers could simplify surgical procedures for implanting such interfaces. Once implanted, wireless strategies for powering and transferring data from the interface can eliminate bulky external wires, reduce infection risk, and enhance day‐to‐day usability. By outlining the current limitations of neuromuscular interfaces along with potential future directions, this review aims to guide continued research efforts and future collaborations between engineers and specialists in the field of neuromuscular and musculoskeletal medicine.

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“…An important point to consider when RPNIs are going to be utilized with implanted muscle electrodes is the time of electrode placement. A recent study explored the effects of epimysial electrode installation and stimulation of deinnervated and devascularized free muscle grafts during the early recovery phase [44]. Histologic results showed an inflammatory state, and abnormal EMG signals with easier fatigability of the muscles, suggestive of myopathy.…”

Section: Myoelectric Systemsmentioning

confidence: 99%

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Yildiz

Shin

Kaufman

2020

J NeuroEngineering Rehabil

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The field of prosthetics has been evolving and advancing over the past decade, as patients with missing extremities are expecting to control their prostheses in as normal a way as possible. Scientists have attempted to satisfy this expectation by designing a connection between the nervous system of the patient and the prosthetic limb, creating the field of neuroprosthetics. In this paper, we broadly review the techniques used to bridge the patient's peripheral nervous system to a prosthetic limb. First, we describe the electrical methods including myoelectric systems, surgical innovations and the role of nerve electrodes. We then describe non-electrical methods used alone or in combination with electrical methods. Design concerns from an engineering point of view are explored, and novel improvements to obtain a more stable interface are described. Finally, a critique of the methods with respect to their long-term impacts is provided. In this review, nerve electrodes are found to be one of the most promising interfaces in the future for intuitive user control. Clinical trials with larger patient populations, and for longer periods of time for certain interfaces, will help to evaluate the clinical application of nerve electrodes.

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Polyimide Electrode-Based Electrical Stimulation Impedes Early Stage Muscle Graft Regeneration

Cited by 8 publications

References 51 publications

Myoelectric control of robotic lower limb prostheses: a review of electromyography interfaces, control paradigms, challenges and future directions

Myoelectric control of robotic lower limb prostheses: a review of electromyography interfaces, control paradigms, challenges and future directions

Neuromuscular implants: Interfacing with skeletal muscle for improved clinical translation of prosthetic limbs

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

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