Polyhydroxybutyrate/Hydroxyapatite Highly Porous Scaffold for Small Bone Defects Replacement in the Nonload-bearing Parts

Сенатов, Ф.С.; Anisimova, Natalia; Kiselevskiy, Mikhail; Kopylov, A.N.; Tcherdyntsev, Victor V.; Maksimkin, Aleksey V.

doi:10.1016/s1672-6529(16)60431-6

Cited by 33 publications

(15 citation statements)

References 35 publications

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“…135 In another study, PHB/HA porous composites had been developed via sintering. 136 The results revealed that high mechanical properties were achieved for PHB/20%…”

Section: Tissue Engineeringmentioning

confidence: 95%

“…The study revealed the growth of human mesenchymal stromal cells on the PHB/HA composite scaffolds for tissue engineering applications . In another study, PHB/HA porous composites had been developed via sintering . The results revealed that high mechanical properties were achieved for PHB/20% HA with pore size in the range of 50–500 μm, compression strength of 106 MPa and the Young's modulus as 901 MPa.…”

Section: Applications Of Phb Based Biocompositesmentioning

confidence: 97%

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Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Raza

Noor

Khalil

2019

Biotechnology Progress

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Poly(hydroxybutyrate) (PHB) has become an attractive biomaterial in research and development for past few years. It is natural bio‐based aliphatic polyester produced by many types of bacteria. Due to its biodegradable, biocompatible, and eco‐friendly nature, PHB can be used in line with bioactive species. However, high production cost, thermal instability, and poor mechanical properties limit its desirable applications. So there is need to incorporate PHB with other materials or biopolymers for the development of some novel PHB based biocomposites for value addition. Many attempts have been employed to incorporate PHB with other biomaterials (or biopolymers) to develop sustainable biocomposites. In this review, some recent developments in the synthesis of PHB based biocomposites and their biomedical, packaging and tissue engineering applications have been focused. The development of biodegradable PHB based biocomposites with improved mechanical properties could be used to overcome its native limitations hence to open new possibilities for industrial applications.

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“…135 In another study, PHB/HA porous composites had been developed via sintering. 136 The results revealed that high mechanical properties were achieved for PHB/20%…”

Section: Tissue Engineeringmentioning

confidence: 95%

Section: Applications Of Phb Based Biocompositesmentioning

confidence: 97%

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Raza

Noor

Khalil

2019

Biotechnology Progress

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“…MMSCs were generated from dog bone marrow and characterized as we described early (Senatov et al, ). For the studies PI (+)CD34(−)CD45(−)CD105(+) cells of the third passage were used.…”

Section: Methodsmentioning

confidence: 99%

“…The negative and positive groups were 5 ml of PBS with 0.1 ml of diluted blood and 5 ml of distilled water with 0.1 ml of diluted blood, respectively. The hemolysis ratio was evaluated as described early (Senatov et al, ).…”

Section: Methodsmentioning

confidence: 99%

The influence of ultrafine‐grained structure on the mechanical properties and biocompatibility of austenitic stainless steels

et al. 2019

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In this study, equal‐channel angular pressing (ECAP) of austenitic 316L and Cr–Ni–Ti stainless steels was carried out. Effect of ECAP at 400°C on the evolution of the microstructure, mechanical properties, and biocompatibility of these steels was investigated. The biocompatibility of samples with the ultrafine grain structure obtained in the ECAP process did not deteriorate in comparison with an austenitic 316L stainless steel in coarse‐grained state. However, this treatment enhances the multipotent mesenchymal stromal/stem cell proliferation by 26% for 316L steel and by 17% for Cr–Ni–Ti stainless steel in comparison with coarse‐grained counterparts. At the same time, ECAP contributes to a significant improvement in performance and weight reduction of medical devices, which is especially important for the creation of implanted prostheses for replacement of skeletal defects, due to significant increase in specific strength of steels. The strength properties of austenitic stainless steels were remarkably improved due to the grain refinement and deformation twinning resulted from ECAP at 400°C. After ECAP, the yield strength of 316L and Cr–Ni–Ti stainless steels increased by 4.2 and 2.9 times up to 950 and 900 MPa, and the fatigue limit by 2 and 1.7 times up to 500 and 475 MPa, respectively, comparing to coarse‐grained counterparts.

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“…В силу биоинертности, а также приемлемых механических свойств и износостойкости растёт сфера применения СВМПЭ в хирургии -при создании имплантов костей и суставов, а в последнее время и в процессах реконструкции на клеточном уровне, в качестве скаффолдов для тканевой инженерии [13]. Будучи колонизированными мезенхимальными стромальными клетками, скаффолды из СВМПЭ с открытой пористостью демонстрируют высокую способность к остеоинтеграции и васкуляризации [21].…”

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Особенности Формирования Колониальных Поселений Морских Бентосных Диатомей На Поверхности Синтетического Полимера

Sapozhnikov

Salimon

Korsunsky

et al. 2020

mbj

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The topic of interactions between plastic and natural communities is now more relevant than ever before. Gradual accumulation of artificial polymer products and their fragments in the natural environment has reached a level at which it is already impossible to ignore the affect of these materials on living organisms. First and foremost, microorganism colonies inhabiting different biotopes, both aquatic and terrestrial, have been affected. These species are at the front-end of interaction with plastic, including those present in marine ecosystems. Nevertheless, in order to understand these processes, it is necessary to take into account several aspects of such interactions: the impact of different types of plastic on microbial community through the release of their decomposed products into the environment, the forms of plastic usage by microorganisms themselves, including mechanisms for surface colonization, as well as possible biodegradation processes of polymers due to the actions of microorganisms. At the same time, types of plastic may differ not only in mechanical strength, but also in their resistance to biodegradation caused by microorganisms. Experiments with surface colonization of types of plastic, which are different in composition and mechanical strength, provide a wide range of results that are not just relevant for understanding modern natural processes involving plastic: these results are also important for application in certain areas of technology development (for example, when creating composite materials). In particular, researches into the forms and mechanisms of sustainable colonization of particularly strong polymers by diatoms from natural communities are of great interest. Due to the fouling of surface of particularly strong synthetic polymers by diatoms, it is possible to form a single diatom-polymeric composite with general properties being already substantially different from those of the polymer itself. For example, when a polymer is fouled with diatoms that are firmly held on its surface due to physiological mechanisms that ensure their reliable fixation, total surface area of the composite increases by 2–3 orders of magnitude compared with this of bare polymer. Such composites and their properties are formed due to mechanisms of substrate colonization used by diatoms from natural marine cenoses – during the transfer of these mechanisms to a new material being prospective for diatom settlement. The practical applications of these composites lie in the sphere of heat and sound insulation, as well as in the field of creating prosthetic tissues for bone operations. In our experiments, we tracked the sequence of development of a stable composite when diatoms colonized the surface of samples of a particularly strong synthetic polymer being resistant to corrosion. In this case, the sample population process took place on the basis of colonies formed in accumulative cultures from the natural marine environment. Samples of ultra-high molecular weight polyethylene (UHMWPE) with a smooth and porous surface structure (with an open cell, bulk porosity up to 80 %) were colonized by diatoms Karayevia amoena (Hust.) Bukht., 2006, Halamphora coffeaeformis (C. Agardh) Levkov, 2009, and Halamphora cymbifera (W. Greg.) Levkov, 2009. These laboratory experiments lasted for three weeks. Accumulative microphyte cultures, on the basis of which the experiments were conducted, were obtained from the Baltic Sea (Baltiysk area, Russia) and the Arabian Sea (Mumbai area, India). The types and stages of development of colonial settlements on various elements of the frontal surface microrelief and in the underlying caverns were studied using a scanning electron microscope on samples subjected to stepwise thermal drying. Individual cells of K. amoena, H. coffeaeformis, and H. cymbifera, their chain-like aggregates, and outstretched colonial settlements occupied varying in degree non-homogeneous microrelief surface elements, forming structures with a thickness of 1–2 layers with an average settlement height of 1–1.3 single specimen height. K. amoena cells were tightly fixed to the polymer substrate using the pore apparatus of the lower cell flap. Observations using scanning electron microscope revealed shell imprints on the substrate, which were signs of a polymer substrate introduction into hypothec areoles. The spread mechanisms of diatoms of three mentioned species on various elements of UHMWPE surface were explored, as well as the formation of the characteristic elements of colonial settlements, including for K. amoena – consecutively in the form of “pots” and spheres, by means of interaction with polymer surface and its extension with the increase in the number of tightly attached cells in the colonial settlement.

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Polyhydroxybutyrate/Hydroxyapatite Highly Porous Scaffold for Small Bone Defects Replacement in the Nonload-bearing Parts

Cited by 33 publications

References 35 publications

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

The influence of ultrafine‐grained structure on the mechanical properties and biocompatibility of austenitic stainless steels

Особенности Формирования Колониальных Поселений Морских Бентосных Диатомей На Поверхности Синтетического Полимера

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