Polyhydroxybutyrate and phenolic compounds microalgae electrospun nanofibers: A novel nanomaterial with antibacterial activity

Kuntzler, Suelen Goettems; Almeida, Ana Claudia Araujo de; Costa, Jorge Alberto Vieira; Morais, Michele Greque de

doi:10.1016/j.ijbiomac.2018.03.002

Cited by 46 publications

(27 citation statements)

References 31 publications

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“…Considering the factors detected by a careful literature search on parameters that could influence production of nanostructures using the electrospinning process, feeding rate (150-3000 µL·h −1 , PEO concentration (1%-8% w/v), NaCl concentration (0%-2.5% w/v), tip-to-collector distance (TCD) (10-15 cm), and applied voltage (10-24 kV) featured among the main findings [22][23][24][25][38][39][40][41][42]. Unexpectedly, in contradiction to the results presented in the consulted literature, none of the assays performed using PEO concentrations under 6% formed any kind of polymeric structures and, in all cases, regardless of any other parameter adjustment within the aforementioned ranges, the solution would drop as it went through the TCD and contacted the collector.…”

Section: Electrospinning Processmentioning

confidence: 99%

“…Most of all, the procedure does not require specific solutions and can be executed under ambient temperature [2]. Although the electrospinning technique has already been applied to obtain nanostructures using PEO as the basis [22][23][24][25], none of the consulted manuscripts have simultaneously evaluated the main parameters of the electrospinning process. Hence, we hypothesized that variations in process settings allied to changes in polymer and NaCl concentrations will affect the resulting material in terms of structure, form, and size.…”

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of Electrospun Nanostructures Using Polyethylene Oxide: Potential Means for Incorporation of Bioactive Compounds

Ramos

Giaconia

Marco

et al. 2020

Colloids and Interfaces

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The development of processes for stabilization of the properties of bioactive compounds has been studied in recent years, and the use of nanotechnology is among the most discussed routes. The present work addressed the assembly of nanostructures using polyethylene oxide (PEO), the production of core-shell nanofibers (NFs) with bioactive compounds, and the evaluation of their microscopic and physical characteristics. Aqueous solutions of PEO were electrospun by varying different process and solution parameters (PEO and NaCl concentrations, feeding rate, the tip-to-collector distance (TCD), and applied voltage) in order to optimize production of nanostructures. The best condition obtained was evaluated to form core-shell NFs composed by jussara pulp as a source of anthocyanins. To assess the production of NFs with PEO and jussara pulp, feed solutions were prepared in acetate buffer (pH 4.5) with 6% PEO and 10% lyophilized jussara pulp, at a feeding rate of 150 μL·h−1 and TCD of 15 cm using an applied voltage of 10 kV to form core-shell NFs. The results revealed the formation of core-shell NFs with a diameter of 126.5 ± 50.0 nm. The outcomes achieved represent a crucial step in the application of anthocyanins in food systems as pigments, establishing a basis for further research on the incorporation of nanomaterials into foodstuff.

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Section: Electrospinning Processmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Electrospun Nanostructures Using Polyethylene Oxide: Potential Means for Incorporation of Bioactive Compounds

Ramos

Giaconia

Marco

et al. 2020

Colloids and Interfaces

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“…This paper also reported the average fibre diameters were found to be decreased from 1.59 to 1.17 lm when the applied voltage is increased [7]. Another recent study by Kuntzler et al [16] and Morais et al [17], the optimum conditions of their experiment was processed at 15 kV electric potential, and 0.45 mm diameter of the extrusion capillary. Reduced nanofibre diameter was caused by the superior conductivity of the solution.…”

Section: Effect Of Applied Voltage On the Fabrication Of Pha Electrosmentioning

confidence: 58%

Physicochemical characteristics of poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) electrospun nanofibres for the adsorption of phenol

Jasni

Sudesh

Sagadevan

et al. 2020

Journal of Experimental Nanoscience

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“…As well as proteins and carbohydrate polymers, other types of natural polymers have been used as materials for electrospinning of nanofibers. Poly (hydroxybutyrate) (PHB) is natural polyester that belongs to the class of polyhydroxyalkanoates and is produced by a wide range of microorganisms (Kuntzler et al, 2018). PHB is a fully biodegradable and biocompatible polymer that can be blended with other synthetic or natural polymers to improve its properties (Bonartsev et al, 2007).…”

Section: Polymers Natural Polymersmentioning

confidence: 99%

“…LEB 18, and this was used to make nanofibers that additionally contained cyanobacterial phenolic compounds that have antibacterial, antifungal, and antioxidant activities. These nanofibers inhibited the growth of Staphylococcus aureus ATCC 25923, and they were suggested for use in food packaging (Kuntzler et al, 2018).…”

Section: Bacteria Fungi Stem Cells and Viruses In Nanofibers Bacteriamentioning

confidence: 99%

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Stojanov

Berlec

2020

Front. Bioeng. Biotechnol.

124

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Electrospinning is a technique that uses polymer solutions and strong electric fields to produce nano-sized fibers that have wide-ranging applications. We present here an overview of the use of electrospinning to incorporate biological products into nanofibers, including microorganisms, cells, proteins, and nucleic acids. Although the conditions used during electrospinning limit the already problematic viability/stability of such biological products, their effective incorporation into nanofibers has been shown to be feasible. Synthetic polymers have been more frequently applied to make nanofibers than natural polymers. Polymer blends are commonly used to achieve favorable physical properties of nanofibers. The majority of nanofibers that contain biological product have been designed for therapeutic applications. The incorporation of these biological products into nanofibers can promote their stability or viability, and also allow their delivery to a desired tissue or organ. Other applications include plant protection in agriculture, fermentation in the food industry, biocatalytic environmental remediation, and biosensing. Live cells that have been incorporated into nanofibers include bacteria and fungi. Nanofibers have served as scaffolds for stem cells seeded on a surface, to enable their delivery and application in tissue regeneration and wound healing. Viruses incorporated into nanofibers have been used in gene delivery, as well as in therapies against bacterial infections and cancers. Proteins (hormones, growth factors, and enzymes) and nucleic acids (DNA and RNA) have been incorporated into nanofibers, mainly to treat diseases and enhance their stability. To summarize, incorporation of biological products into nanofibers has numerous advantages, such as providing protection and facilitating controlled delivery from a solid form with a large surface area. Future studies should address the challenge of transferring nanofibers with biological products into practical and industrial use.

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Polyhydroxybutyrate and phenolic compounds microalgae electrospun nanofibers: A novel nanomaterial with antibacterial activity

Cited by 46 publications

References 31 publications

Development and Characterization of Electrospun Nanostructures Using Polyethylene Oxide: Potential Means for Incorporation of Bioactive Compounds

Development and Characterization of Electrospun Nanostructures Using Polyethylene Oxide: Potential Means for Incorporation of Bioactive Compounds

Physicochemical characteristics of poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) electrospun nanofibres for the adsorption of phenol

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

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