Polyherbal formulation exerts wound healing, anti-inflammatory, angiogenic and antimicrobial properties: Potential role in the treatment of diabetic foot ulcers

Chumpolphant, Sawarin; Suwatronnakorn, Maneewan; Issaravanich, Somchai; Tencomnao, Tewin; Prasansuklab, Anchalee

doi:10.1016/j.sjbs.2022.103330

Cited by 11 publications

(9 citation statements)

References 29 publications

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“…These were similar to a systematic review done in 2017 by Chongmelaxme et al 15 Even in two more recent studies, with very similar application but more mixed herbs, adverse events were still not found. 24,25 However, quality of life scores were not significantly different between groups at week 4, even though the quality-of-life scores were improved in each groups. This could be explained by the standard treatment both groups had received: 300 mg gabapentin, once a day.…”

Section: Discussionmentioning

confidence: 89%

“…Until now (December 2022), there has been no other trial that studied the efficacy of Plai on reducing pain in PDN. However, previous studies had shown that Plai being main component in mixed herbal preparations, is safe 24 and effective 25 in treating diabetic foot ulcers. Moreover, Plai has local anesthetic [20][21][22][23] and neuroprotective 28 effects, in addition to its effects on anti-inflammation [12][13][14][15] and pain relief.…”

Section: Discussionmentioning

confidence: 99%

“…[20][21][22][23] Although there were two successful studies of mixed multi-herbal preparation using Zingiber cassumunar Roxb. as its main component in treating diabetic foot ulcers, 24,25 there still has been no study regarding the use of Plai as a treatment in PDN. Therefore, this study aimed to evaluate the efficacy of a topical Zingiber cassumunar preparation by comparing with placebo on PDN.…”

Section: Introductionmentioning

confidence: 99%

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Effect of topical Zingiber cassumunar on painful diabetic neuropathy: a double-blind randomized-controlled trial

Jatuten¹,

Piyakunmala

Budkaew

et al. 2023

F1000Res

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Background: Plai or Zingiber cassumunar Roxb. was registered into the Thai Traditional Medicine list since 2011. However, there is limited evidence regarding Plai as a treatment in painful diabetic neuropathy (PDN). Therefore, this study aimed to evaluate the efficacy of topical Zingiber cassumunar. Methods: A RCT was conducted in patients with PDN during February to March 2019. All participants received oral gabapentin 300 mg before bed as a standard regimen. The intervention group (n=16) received Plai balm 15%w/w 0.5 gram to apply on their feet three times a day and the control group (n=15) received placebo balm to similarly apply. Pain score at baseline, 2nd and 4th weeks were assessed and compared. Patients’ quality of life, and adverse events, were collected. Mean pain scores before and after treatment in each group and between groups were also analyzed. Results: At the end of week two and week four, the Plai group showed statistically significant lesser mean pain scores than the placebo group by -1.47 (95%CI: -1.96 to -1.30, p-value < 0.001), and by -1.51 (95%CI: -1.92 to -0.13, p-value = 0.027), respectively. Moreover, the Plai group had more cases number/ percentages with at least 50% pain score reduction than the placebo group [12/16 (75%) vs 3/15 (20%), p-value = 0.004]. However, there was no statistically significant difference in quality of life between the two groups (overall p-value = 0.366). Adverse event was not found in any groups. Conclusions: Zingiber cassumunar balm (Plai) was efficacious for pain reduction in painful diabetic neuropathy. Registration: Registered with the Thai Clinical Trials Registry; TCTR20200221001.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of topical Zingiber cassumunar on painful diabetic neuropathy: a double-blind randomized-controlled trial

Jatuten¹,

Piyakunmala

Budkaew

et al. 2023

F1000Res

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“…Other naturally derived treatments which promote wound healing by enhancing the expression of TGF-β1 have also been described. Examples of treatments include β-acetoxyisovaleryl alkannin, polyherbal formulations and the flavonoids, vicenin-2 and hesperidin [ 39 , 40 , 41 , 42 ]. Polyherbal formulations are composed of several Thai plant extracts including Curcuma longa Linn and Zingiber cassumunar Roxb.…”

Section: Tgf-β Signallingmentioning

confidence: 99%

“…Polyherbal formulations are composed of several Thai plant extracts including Curcuma longa Linn and Zingiber cassumunar Roxb. Treatment of HaCaT with the polyherbal formulations under high-glucose conditions promoted the migration of HaCaT cells characterised by the increase in the expression of TGF-β1 [ 39 ]. Further in vivo studies are required to confirm the effect of such polyherbal formulations on chronic wound healing.…”

Section: Tgf-β Signallingmentioning

confidence: 99%

Targeting Signalling Pathways in Chronic Wound Healing

Bonnici,

Suleiman,

Schembri-Wismayer

et al. 2023

IJMS

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Chronic wounds fail to achieve complete closure and are an economic burden to healthcare systems due to the limited treatment options and constant medical attention. Chronic wounds are characterised by dysregulated signalling pathways. Research has focused on naturally derived compounds, stem-cell-based therapy, small molecule drugs, oligonucleotide delivery nanoparticles, exosomes and peptide-based platforms. The phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT), Wingless-related integration (Wnt)/β-catenin, transforming growth factor-β (TGF-β), nuclear factor erythroid 2–related factor 2 (Nrf2), Notch and hypoxia-inducible factor 1 (HIF-1) signalling pathways have critical roles in wound healing by modulating the inflammatory, proliferative and remodelling phases. Moreover, several regulators of the signalling pathways were demonstrated to be potential treatment targets. In this review, the current research on targeting signalling pathways under chronic wound conditions will be discussed together with implications for future studies.

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Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies

Yadav,

Singh,

Grishina

et al. 2024

Inflammopharmacol

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Polyherbal formulation exerts wound healing, anti-inflammatory, angiogenic and antimicrobial properties: Potential role in the treatment of diabetic foot ulcers

Cited by 11 publications

References 29 publications

Effect of topical Zingiber cassumunar on painful diabetic neuropathy: a double-blind randomized-controlled trial

Effect of topical Zingiber cassumunar on painful diabetic neuropathy: a double-blind randomized-controlled trial

Targeting Signalling Pathways in Chronic Wound Healing

Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies

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