Polyhedral Oligomeric Silsesquioxanes (Poss) Bioconjugates

Zhang, Zhenghe; Hong, Lizhi

doi:10.1002/9781118775882.ch13

Cited by 3 publications

(2 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous attractive features of this group of compounds distinguish them as unique carriers, such as their nano-size and well-defined shape, thermodynamic stability, biocompatibility, biodegradability, lack of toxicity, high solubility and easy modification. Therapeutics conjugated with POSSs are characterized by selective accumulation in solid tumors and a slower release rate [ 20 ]. Our studies show that POSS:DOX at a 1:8 molar ratio demonstrates higher cytotoxicity for cancer cell lines when compared to free doxorubicin.…”

Section: Discussionmentioning

confidence: 99%

Unusual Enhancement of Doxorubicin Activity on Co-Delivery with Polyhedral Oligomeric Silsesquioxane (POSS)

et al. 2017

View full text Add to dashboard Cite

Polyhedral oligomeric silsesquioxane (POSS), bearing eight 3-chloroammoniumpropyl substituents, was studied as a potential nanocarrier in co-delivery systems with doxorubicin (DOX). The toxicity of doxorubicin and POSS:DOX complexes at four different molar ratios (1:1; 1:2, 1:4, 1:8) towards microvascular endothelial cells (HMEC-1), breast cancer cells (MCF-7), and human cervical cancer endothelial cells (HeLa) was determined. The rate of penetration of the components into the cells, their cellular localization and the hydrodynamic diameter of the complexes was also determined. A cytotoxicity profile of POSS:DOX complexes indicated that the POSS:DOX system at the molar ratio of 1:8 was more effective than free DOX. Confocal images showed that DOX co-delivery with POSS allowed for more effective penetration of doxorubicin through the cell membrane. Taking all the results into account, it can be claimed that the polyhedral oligomeric silsesquioxane (T8-POSS) is a promising, complex nanocarrier for doxorubicin delivery.

show abstract

Section: Discussionmentioning

confidence: 99%

Unusual Enhancement of Doxorubicin Activity on Co-Delivery with Polyhedral Oligomeric Silsesquioxane (POSS)

et al. 2017

View full text Add to dashboard Cite

show abstract

“…51 Nevertheless, local acquaintances and relatives went to Zhang's provincial house and asked for help, which pushed him to pay a visit to Cao County and Wuwei. 52 What he found out was devastating. On 7 July, he delivered a talk to the Five-Level-Cadre conference in Wuwei.…”

Section: The Summer Crisis and The Arrival Of Zhang Kaifanmentioning

confidence: 99%

Grain, Local Politics, and the Making of Mao's Famine in Wuwei, 1958–1961

Shu-ji

Bin

2015

Mod. Asian Stud.

View full text Add to dashboard Cite

Mao's Great Famine in Wuwei County, Anhui Province, between the years of 1958 and 1960, resulted in the deaths of about 245,000 people, a quarter of the local population. By focusing on grain production and consumption, this article adopts a local perspective to examine the county's official archives and analyse the background, rationale, and processes of local authorities that led to one of the highest death rates in the country. A local perspective provides an empirical microanalysis of the Great Famine; illustrates the complexity of this catastrophe; argues for local factors such as factional struggles, central-local interactions, and the political atmosphere created by the series of pre-1958 campaigns as key to local variations of the disaster; and delivers national implications for viewing Mao's China. Official archives explored in this article reveal that an over-reporting of grain output might have resulted in the Great Famine, but did not necessarily lead to the massive death toll, and that local politics, particularly intra-party factional struggles, intertwined with central-local political interactions, were crucial for the terrible tragedy that ensued in Wuwei, and that the end of this famine resulted not from peasants’ resistance, nor the change of radical polices to moderate ones, but from the decreased demand for grain caused by the massive number of deaths.

show abstract

1,3‐Dipolar Cycloaddition Reactions of Nitrile Oxides under “Non‐Conventional” Conditions: Green Solvents, Irradiation, and Continuous Flow

Plumet

2020

ChemPlusChem

View full text Add to dashboard Cite

The 1,3‐dipolar cycloaddition reactions (DCs) of nitrile oxides (NOs) to alkenes and alkynes are useful methods for the synthesis of 2‐isoxazolines and isoxazoles respectively, which are important classes of heterocyclic compounds in organic and medicinal chemistry. Most of these reactions are carried out in organic solvents and under thermal activation. Nevertheless the use of supercritical carbon dioxide (scCO2) and ionic liquids (Ils) as alternative solvents and the application of microwave (MW) and ultrasound (US) as alternative activation procedures have evident advantages from the “Green Chemistry” point of view. The critical discussion on the applications of these “unconventional” activation methods and reaction conditions in the 1,3‐DCs of NOs is the objective of the present Review.

show abstract

Polyhedral Oligomeric Silsesquioxanes (Poss) Bioconjugates

Cited by 3 publications

References 94 publications

Unusual Enhancement of Doxorubicin Activity on Co-Delivery with Polyhedral Oligomeric Silsesquioxane (POSS)

Unusual Enhancement of Doxorubicin Activity on Co-Delivery with Polyhedral Oligomeric Silsesquioxane (POSS)

Grain, Local Politics, and the Making of Mao's Famine in Wuwei, 1958–1961

1,3‐Dipolar Cycloaddition Reactions of Nitrile Oxides under “Non‐Conventional” Conditions: Green Solvents, Irradiation, and Continuous Flow

Contact Info

Product

Resources

About