Polyhedral oligomeric silsesquioxanes as functional monomer to prepare hybrid monolithic columns for capillary electrochromatography and capillary liquid chromatography

Tailor‐Made Hybrid Organic–Inorganic Porous Materials Based on Polyhedral Oligomeric Silsesquioxanes (POSS) by the Step‐Growth Mechanism of Thiol‐Ene “Click” Chemistry

“…[7] The preparation of monolithic porous materials involving POSS has often been addressed with amines, [8] and through uncontrolled, free-radical copolymerization with other monomers. [9] Recently, porous monolithic adsorbents prepared by simple free-radical polymerization of vinylPOSS have been reported. These studies indicated low reactivity of the tightly tethered vinyl group in free radical polymerization.…”

Chromatographic efficiency comparison of polyhedral oligomeric silsesquioxanes-containing hybrid monoliths via photo- and thermally-initiated free-radical polymerization in capillary liquid chromatography for small molecules

“…Numerous monoliths including common polymeric and silicabased monoliths [4] have been developed for the separations of small molecules and high-molecular-weight molecules such as proteins and nucleic acids. As an alternative to organic and silica monoliths, organic-silica hybrid monoliths somewhat blended the merits of organic and silica monoliths such as ease of preparation, less shrinkage, good mechanical stability, wide pH range tolerance and high surface area, and have been applied as the separation matrix of chromatographic columns [5] and immobilized as the precursors to fabricate a series of hybrid monoliths via thermally-initiated free-radical polymerization by us [12] and other groups [13,14]. As expected, these POSS-containing monoliths exhibited good mechanical stability and good pH stability.…”

Preparation of high efficiency and low carry-over immobilized enzymatic reactor with methacrylic acid–silica hybrid monolith as matrix for on-line protein digestion

“…Compared to polymer monoliths, hybrid silica monoliths have higher binding capacity, and better permeability, mechanical strength and organic solvent tolerance [20][21][22], making them superior supports for enzyme immobilization. Ma et al [23] developed a novel immobilized trypsin reactor based on organic-inorganic hybrid silica monoliths.…”