Polyhedral Oligomeric Silsesquioxane Nanocomposites: The Next Generation Material for Biomedical Applications

Kannan, Ruben Y.; Salacinski, Henryk J.; Butler, Peter E.; Seifalian, Alexander M.

doi:10.1002/chin.200606237

Cited by 58 publications

(68 citation statements)

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“…1A). This design is motivated by (i) the well-defined cubic geometry of POSS that enables the grafting of up to eight identical polymer arms, (ii) the capability of the rigid POSS nanoparticle in controlling the grafted polymer chain motions on a molecular scale (15), and (iii) the demonstrated biocompatibility of POSS (16). Polylactides (PLAs) of various lengths were grafted to the octahydroxylated POSS core (Fig.…”

Section: Resultsmentioning

confidence: 99%

High performance shape memory polymer networks based on rigid nanoparticle cores

Song

2010

Proc. Natl. Acad. Sci. U.S.A.

122

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Smart materials that can respond to external stimuli are of widespread interest in biomedical science. Thermal-responsive shape memory polymers, a class of intelligent materials that can be fixed at a temporary shape below their transition temperature (T trans ) and thermally triggered to resume their original shapes on demand, hold great potential as minimally invasive self-fitting tissue scaffolds or implants. The intrinsic mechanism for shape memory behavior of polymers is the freezing and activation of the long-range motion of polymer chain segments below and above T trans , respectively. Both T trans and the extent of polymer chain participation in effective elastic deformation and recovery are determined by the network composition and structure, which are also defining factors for their mechanical properties, degradability, and bioactivities. Such complexity has made it extremely challenging to achieve the ideal combination of a T trans slightly above physiological temperature, rapid and complete recovery, and suitable mechanical and biological properties for clinical applications. Here we report a shape memory polymer network constructed from a polyhedral oligomeric silsesquioxane nanoparticle core functionalized with eight polyester arms. The cross-linked networks comprising this macromer possessed a gigapascal-storage modulus at body temperature and a T trans between 42 and 48°C. The materials could stably hold their temporary shapes for >1 year at room temperature and achieve full shape recovery ≤51°C in a matter of seconds. Their versatile structures allowed for tunable biodegradability and biofunctionalizability. These materials have tremendous promise for tissue engineering applications.nanocompsite | shape memory materials | thermal responsive materials A thermal-responsive shape memory polymer (SMP) can be imparted with a "permanent" shape above a critical transition temperature (T trans ) when it is cast in a mold. For polymers, the T trans is either glass transition temperature T g or melting temperature T m . Such a permanent shape, formed at the elastic state of the material without external stress, is retained (memorized) as the SMP cools to a temperature below its T trans . The SMP can be deformed into a desired "temporary" shape by force at T > T trans , and this strained configuration can be fixed as the temperature cools below the T trans . When a thermal stimulus above the T trans is reapplied, however, the SMP recovers to its less strained permanent shape. This unique shape memory behavior has captured the imagination of the biomedical community as scientists strive to design smart implants and tissue scaffolds that can be delivered in a minimally invasive configuration and be subsequently reverted to a preprogrammed permanent shape in vivo.Since the first demonstration of degradable SMPs for potential tissue engineering applications (1, 2), many semicrystalline and amorphous polyester and polyurethane SMP networks have been reported. Adjustment of thermomechanical properties and degrad...

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Section: Resultsmentioning

confidence: 99%

High performance shape memory polymer networks based on rigid nanoparticle cores

Song

2010

Proc. Natl. Acad. Sci. U.S.A.

122

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“…These are the most commonly studied POSS systems and therefore often utilized as nanoparticles. The substituent groups are often hydrocarbon chains or other similar organic derivatives [7][8][9] and can be functionalized to compatiblize them with host polymers or biomaterials [2,5,10].…”

Section: Introductionmentioning

confidence: 99%

Morphology and crystallization kinetics of polyethylene/long alkyl-chain substituted Polyhedral Oligomeric Silsesquioxanes (POSS) nanocomposite blends: A SAXS/WAXS study

Heeley

Hughes

Aziz

et al. 2014

European Polymer Journal

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The dispersal, quiescent crystallization kinetics and morphology of a series of unique polyethylene -polyhedral oligomeric silsesquioxanes (PE-POSS) nanocomposite blends is presented. POSS molecules with long linear alkyl-chain substituents were blended at one composition into a commercial low density polyethylene. Time-resolved Small-and WideAngle X-Ray scattering (SAXS/WAXS) and thermal techniques were used to elucidate the affect that POSS and its substituent groups have on the dispersal and crystallization kinetics of the host polymer. The miscibility and dispersal of the POSS molecules was seen to increase with the increasing alkyl-chain length substituents suggesting increased compatibility and interaction with the host polymer chains. The POSS molecules act as nucleating agents increasing the crystallinity, crystallization kinetics and influencing the final lamellar morphology. Thus, these unique POSS compounds show great potential as nancomposite filler particles in polyolefins where the alkyl-chain substituent plays a vital role in its compatibility and subsequent improvement of physical properties in the host polymer.

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“…7 Another novel possibility is to functionalize CNTs with nanocomposite polymers, 39 for instance, POSS-PCU, 40 increasing the dispersion of CNTs in biological systems 41 due to its amphiphilic nature. 42 POSS-PCU is a thermoplastic that is resistant to degradation 43 and has anticalcification effects; 44 it demonstrates superior biocompatibility and is currently being assessed for use in medical implants. 45 POSS-PCU may be noncovalently bonded to CNTs via π-π interactions of the aromatic rings of the urea hard segment, which bears stark similarities to the bioconjugation of doxorubicin to CNTs.…”

Section: Conjugating Cnts To Qdsmentioning

confidence: 99%

Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment

Madani¹,

Shabani²,

Dwek³

et al. 2013

IJN

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Abstract:Cancer is one of the leading causes of death worldwide and early detection provides the best possible prognosis for cancer patients. Nanotechnology is the branch of engineering that deals with the manipulation of individual atoms and molecules. This area of science has the potential to help identify cancerous cells and to destroy them by various methods such as drug delivery or thermal treatment of cancer. Carbon nanotubes (CNT) and quantum dots (QDs) are the two nanoparticles, which have received considerable interest in view of their application for diagnosis and treatment of cancer. Fluorescent nanoparticles known as QDs are gaining momentum as imaging molecules with life science and clinical applications. Clinically they can be used for localization of cancer cells due to their nano size and ability to penetrate individual cancer cells and high-resolution imaging derived from their narrow emission bands compared with organic dyes. CNTs are of interest to the medical community due to their unique properties such as the ability to deliver drugs to a site of action or convert optical energy into thermal energy. By attaching antibodies that bind specifically to tumor cells, CNTs can navigate to malignant tumors. Once at the tumor site, the CNTs enter into the cancer cells by penetration or endocytosis, allowing drug release, and resulting in specific cancer cell death. Alternatively, CNTs can be exposed to near-infrared light in order to thermally destroy the cancer cells. The amphiphilic nature of CNTs allows them to penetrate the cell membrane and their large surface area (in the order of 2600 m 2 /g) allows drugs to be loaded into the tube and released once inside the cancer cell. Many research laboratories, including our own, are investigating the conjugation of QDs to CNTs to allow localization of the cancer cells in the patient, by imaging with QDs, and subsequent cell killing, via drug release or thermal treatment. This is an area of huge interest and future research and therapy will focus on the multimodality of nanoparticles. In this review, we seek to explore the biomedical applications of QDs conjugated to CNTs, with a particular emphasis on their use as therapeutic platforms in oncology.

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Polyhedral Oligomeric Silsesquioxane Nanocomposites: The Next Generation Material for Biomedical Applications

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 58 publications

References 1 publication

High performance shape memory polymer networks based on rigid nanoparticle cores

High performance shape memory polymer networks based on rigid nanoparticle cores

Morphology and crystallization kinetics of polyethylene/long alkyl-chain substituted Polyhedral Oligomeric Silsesquioxanes (POSS) nanocomposite blends: A SAXS/WAXS study

Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment

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