Polygraphic Recordings in Subacute Sclerosing Panencephalitis – A Study of the Pathophysiology of the Periodic EEG Complexes

Hg, Lenard; Pl, Yaneza; Reimer, Maren

doi:10.1055/s-0028-1091610

Cited by 14 publications

(3 citation statements)

References 19 publications

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“…Subcortical/brainstem neurons may serve as a pacemaker for EEG bursting (Fenoy & Haszons 1964, Lenard et al 1976) and may control fluctuations in HR as well. However, the anatomical location of this control is not clear.…”

Section: Resultsmentioning

confidence: 99%

Atropine abolishes electroencephalogram‐associated heart rate changes without an effect on respiratory sinus arrhythmia during anaesthesia in humans

Yli‐Hankala

Loula

Annila

et al. 1993

Acta Physiologica Scandinavica

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Heart rate fluctuates with the electroencephalogram burst suppression pattern during anaesthesia: increasing at burst onset and decreasing at suppression. Heart rate also oscillates with positive pressure ventilation. The effects of atropine on these heart rate changes were studied in 12 patients during isoflurane anaesthesia and positive pressure ventilation at a frequency of 6 cycles min-1. Four additional patients served as controls. A bolus dose of atropine (20 micrograms kg-1 intravenously) abolished the electroencephalogram-correlated heart rate changes; however, the amplitude of respiratory sinus arrhythmia was not changed after atropine. The control mechanism of the burst suppression pattern in electroencephalogram also affects parasympathetic heart rate control. The control mechanisms of respiratory sinus arrhythmia during anaesthesia with positive pressure ventilation differ from those during spontaneous breathing awake.

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Section: Resultsmentioning

confidence: 99%

Atropine abolishes electroencephalogram‐associated heart rate changes without an effect on respiratory sinus arrhythmia during anaesthesia in humans

Yli‐Hankala

Loula

Annila

et al. 1993

Acta Physiologica Scandinavica

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“…However, there must be an event leading to each discharge. Brainstem structures were suggested to act as a pacemaker by some investigators studying about the discharges in SSPE 31 . Some others suggested that GPEDs arise from a subcortical source in CJD 32,30 .…”

Section: Eeg Features and Prognosismentioning

confidence: 99%

Generalised periodic epileptiform discharges: clinical features, neuroradiological evaluation and prognosis in 37 adult patients

Yemişçi

Gurer

Saygı

et al. 2003

Seizure

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Generalised periodic epileptiform discharges (GPEDs) are very rare patterns and are classified as periodic short-interval diffuse discharges (PSIDDs), periodic long-interval diffuse discharges (PLIDDs) and suppression-burst patterns according to the interval between the discharges. In this study we analysed the demographics, history of the seizures during the current illness, mental status, diagnosis, metabolic abnormalities, neuroimaging studies and prognosis of 37 adult patients who had GPEDs in their EEGs. Ages ranged from 17 to 82 years (mean 45 years). There were 19 males and 18 females. The most common aetiology of GPEDs was metabolic and/or infectious disease which was established in 22 patients (59.5%). Other aetiologies included subacute sclerosing panencephalitis (SSPE) in 11 patients (29.7%) and Creutzfeld-Jakob disease (CJD) in 4 patients (10.8%). We showed that structural lesions were found in most of the patients with GPEDs, but concurrent metabolic abnormalities and/or infectious diseases were also detected. Consciousness was impaired and clinical conditions were poor in various degrees in all of the patients when GPEDs were seen. Relatively little is known regarding the mechanism of GPEDs. When GPEDs are seen in EEG, the patient should carefully be checked for metabolic abnormalities and/or infectious diseases and intracranial lesions. GPEDs may be helpful in the determination of prognosis, showing the poor prognosis especially in cases when suppression-burst pattern is seen.

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“…This does not explain cases of HIE-BS with prolonged mean IBI durations and little variability. Gloor et al (1968) believe that periodicity develops following cortical and subcortical grey matter damage, that bursting is a reflection of cortical neuronal excitability to input from subcortical (Gloor et al 1968;Lenard et al 1976) or brain-stem regions (Fenyo and Hasznos 1964) and that the IBI is a reflection of the refractory period of cortical or subcortical/ brain-stem neurons. This hypothesis of a subcortical/ brain-stem pacemaker accounting for the BS periodic-ity could explain prolonged mean IBI durations with little variability in some cases with HIE-BS.…”

Section: Although the Eeg Pattern Of Bs Is Characteristic There Are mentioning

confidence: 99%

Variance of interburst intervals in burst suppression

Beydoun

Yen

Drury

1991

Electroencephalography and Clinical Neurophysiology

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Each EEG performed over a 3 year period at the University of Michigan with a diagnosis of generalized burst-suppression (BS) was reviewed. Ten EEGs from 10 patients with hypoxic-ischemic encephalopathy (HIE-BS) and 21 records from 8 patients with pentobarbital induced burst-suppression for treatment of status epilepticus (SE-BS) were reviewed. For each EEG, the mean duration of 40 interburst intervals (IBIs) as well as their coefficient of variability were calculated. We found that in the SE-BS group the coefficient of variability of IBI duration was highly correlated with the logarithm of mean IBI duration while in the HIE-BS group, there was no significant correlation between these 2 variables. This suggests that the underlying mechanism causing BS is different in the 2 groups and might be related to a uniform and progressive affection of similar brain structures in the SE-BS group and a more patchy and variable pathology in the HIE-BS group.

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Polygraphic Recordings in Subacute Sclerosing Panencephalitis – A Study of the Pathophysiology of the Periodic EEG Complexes

Cited by 14 publications

References 19 publications

Atropine abolishes electroencephalogram‐associated heart rate changes without an effect on respiratory sinus arrhythmia during anaesthesia in humans

Atropine abolishes electroencephalogram‐associated heart rate changes without an effect on respiratory sinus arrhythmia during anaesthesia in humans

Generalised periodic epileptiform discharges: clinical features, neuroradiological evaluation and prognosis in 37 adult patients

Variance of interburst intervals in burst suppression

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