Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of <i>Polygonum multiflorum</i> Thunb

Yang, Jian‐Bo; Li, Li; Dai, Zhong; Yu, Wenchao; Geng, Xin; Li, Bo; Ma, Shuang‐Cheng; Wang, Aiguo; Su, Ya‐Lun

doi:10.1080/10286020.2016.1171758

Cited by 27 publications

(16 citation statements)

References 16 publications

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“…Actually, several novel dianthrone glycosides from PM were elucidated by the conventional phytochemistry methods 4 years later (Yang J. B. et al, 2016 ; Yang et al, 2017a , b ), which confirmed the existence of dianthrone glycosides in PM. Compared with traditional Q-TOF mass spectrometry, UPLC-LTQ-Orbitrap-MS n provides superior resolution and mass accuracy; meanwhile, with the MS n function, the Orbitrap technology can achieve 10 levels of MS analysis capability (Lin et al, 2015d ).…”

Section: Chemical Analysis Of Pmmentioning

confidence: 92%

“…Besides Lin et al ( 2015a ) summarized 103 chemical compounds of PM, one new type agents were discovered by our group (Yang J. B. et al, 2016 ; Yang et al, 2017a , b ), more than 30 novel dianthrone glycosides were elucidated unambiguously by spectroscopic analysis. In addition, the toxicities of parts compounds were evaluated against L-02 cell lines and KB tumor cell lines, and the results indicated that these constituents showed moderate hepatotoxicities.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 94%

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Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity

et al. 2018

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Polygonum multiflorum Thunb. and its processed products have been used in China for centuries due to their multiple beneficial effects to human body. Currently, liver injuries caused by taking P. multiflorum have been reported worldwide, but the potential toxic components and possible mechanism that caused hepatotoxicity remain unclear. It is worth noting that the processing procedure could significantly decrease the toxicity of raw P. multiflorum and the processed products of P. multiflorum are considered to be relatively safe. However, the processing mechanism is still ambiguous, and there is the lack of a scientific approach to control the quality of P. multiflorum praeparata. This study is the first review that summarizes the recently advances (from 2007 to 2017) in the chemical analysis of P. multiflorum, and provides comprehensive information on the quantitative and qualitative analysis of P. multiflorum as well as its related species. In addition, the processing mechanism and quality evaluation of processed P. multiflorum are discussed. Moreover, the toxicity of P. multiflorum is analyzed from the perspectives of exploration of the proposed toxic ingredients, metabolite identification, metabolomics studies, and exogenous contaminant determination. Furthermore, trends and perspectives for future research of this medicine are discussed.

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Section: Chemical Analysis Of Pmmentioning

confidence: 92%

Section: Conclusion and Future Perspectivesmentioning

confidence: 94%

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity

et al. 2018

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“…multiflorum (common names: Polygonum multiflorum Thunb 1 , Polygoni Multiflora Radix 2 , Fallopia multiflora , Heshouwu 3 , fleeceflower root 4 , 5 , Polygoni multiflori 6 , and foti root 7 ) is among the most frequently used medicinal plants in China. The main components of this plant are flavonoids 1 , 8 – 11 , quinones, and anthrones 12 , which are used as ingredients in various medicines. The major quinone constituents of P .…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum

Wang

et al. 2017

Sci Rep

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The adverse effects of Polygonum (P.) multiflorum, including abnormal bilirubin metabolism, are a serious public health issue. As uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme responsible for bilirubin metabolism, we investigated the inhibitory effect of a P. multiflorum extract and 10 anthraquinone and dianthrone compounds on UGT1A1 in rat liver microsomes in vitro. The P. multiflorum extract exhibited the strongest inhibitory effect on UGT1A1 activity (inhibition constant [Ki] = 0.3257 μM, 1422 μg of material/mL), followed by cis-emodin dianthrones (Ki = 0.8630 μM), trans-emodin dianthrones (Ki = 1.083 μM), emodin-8-O-glc (Ki = 3.425 μM), and polygonumnolide C2 (Ki = 4.291 μM). Analysis of the structure–activity relationships of these compounds suggested that the spatial orientation of the molecules and the presence of particular functional groups affect UGT1A1 inhibition. A mechanistic analysis showed that all the tested compounds docked into two of the nine active sites of UGT1A1 and suggested that hydrophobic interactions and hydrogen bonds are important for the affinity of the tested compounds for UGT1A1; moreover, their interaction energies were generally in agreement with the Ki values. These findings provide insight into adverse reactions to P. multiflorum and identify the pharmacophores involved in inhibition of UGT1A1.

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“…Previous chemical investigations revealed that the plant P. multiflorum contains stilbenes, phenolic acids, flavonoids and anthraquinones etc. . These multiple‐bioactive constituents, contributed to the plant, become an important herbal medicine source.…”

Section: Introductionmentioning

confidence: 99%

Rapid Characterization of the major chemical constituents from Polygoni Multiflori Caulis by liquid chromatography tandem mass spectrometry and comparative analysis with Polygoni Multiflori Radix

Wang

Shang

et al. 2017

J. Sep. Sci.

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Polygoni Multiflori Caulis is a traditional Chinese medicine that has been used for a long time to treat sleep disorders. However, the multiple chemical composition analysis has not been reported. In this study, a simple, rapid and effective ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established to characterize the components of Polygoni Multiflori Caulis. In addition, a chemical comparative analysis was performed with Polygoni Multiflori Radix, another traditional Chinese medicine from the same plant, through multivariate statistical analysis and semi-quantitative analysis to screen the difference in chemical ingredients between these two herbal medicines from same medicinal plant. A total of 33 peaks were detected within 25 min, and 28 of them were identified or tentatively characterized by comparing the retention time and mass spectrometry data. Based on the results, 12 characteristic components were screened out by multivariate statistical analysis, and their content change trends were compared by semi-quantitative analysis.

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Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb

Cited by 27 publications

References 16 publications

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity

Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum

Rapid Characterization of the major chemical constituents from Polygoni Multiflori Caulis by liquid chromatography tandem mass spectrometry and comparative analysis with Polygoni Multiflori Radix

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